Browse our RHBDF1 Proteins (RHBDF1)

Full name:
Rhomboid 5 Homolog 1 (Drosophila) Proteins (RHBDF1)
On are 8 Rhomboid 5 Homolog 1 (Drosophila) (RHBDF1) Proteins from 3 different suppliers available. Additionally we are shipping RHBDF1 Antibodies (5) and many more products for this protein. A total of 16 RHBDF1 products are currently listed.
C16ORF8, Dist, Dist1, Egfr-rs, gene-89, gene-90, hDist1, mKIAA4242, zgc:91984
list all proteins Gene Name GeneID UniProt
RHBDF1 64285 Q96CC6
Rat RHBDF1 RHBDF1 303008 Q499S9
RHBDF1 13650 Q6PIX5

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RHBDF1 Proteins (RHBDF1) by Origin

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Human Rhomboid 5 Homolog 1 (Drosophila) (RHBDF1) interaction partners

  1. results explain how loss of the amino terminus in iRhom1 and iRhom2 (show RHBDF2 Proteins) impairs TNF (show TNF Proteins) signaling, despite enhancing ADAM17 (show ADAM17 Proteins) activity

  2. The expression of iRhom1 was increased by endoplasmic reticulum (ER) stressors, such as thapsigargin and tunicamycin, leading to the enhancement of proteasome activity, especially in ER-containing microsomes.

  3. RHBDF1 is a critical component of a molecular switch that regulates HIF1alpha (show HIF1A Proteins) stability in cancer cells in hypoxia.

  4. RHBDF1 is a seven-transmembrane protein with a long N-terminal cytoplasmic extension that comprises half of the polypeptide sequence, and is found in the endoplasmic reticulum and Golgi, but not on the cell surface

  5. RHBDF1 has a pivotal role in sustaining growth signals in epithelial cancer cells and thus may serve as a therapeutic target for treating epithelial cancers.

  6. RHBDF1 is critically involved in a G protein-coupled receptors ligand-stimulated process leading to the activation of latent epidermal growth factor receptor (show EGFR Proteins) ligands

Mouse (Murine) Rhomboid 5 Homolog 1 (Drosophila) (RHBDF1) interaction partners

  1. a principal function of iRhoms1/2 during mouse development is to regulate ADAM17 (show ADAM17 Proteins)-dependent EGFR (show EGFR Proteins) signaling

  2. iRhom1 knockout mice have a severe phenotype, impaired TACE (show ADAM17 Proteins) maturation and die within 6 weeks of birth.

RHBDF1 Protein Profile

Protein Summary

Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration (By similarity).

Alternative names and synonyms associated with RHBDF1

  • rhomboid 5 homolog 1 (Drosophila) (RHBDF1)
  • rhomboid 5 homolog 1 (Drosophila) (rhbdf1)
  • rhomboid 5 homolog 1 (Drosophila) (Rhbdf1)
  • rhomboid family 1 (Drosophila) (Rhbdf1)
  • C16ORF8 protein
  • Dist protein
  • Dist1 protein
  • Egfr-rs protein
  • gene-89 protein
  • gene-90 protein
  • hDist1 protein
  • mKIAA4242 protein
  • zgc:91984 protein

Protein level used designations for RHBDF1

rhomboid 5 homolog 1 (Drosophila) , rhomboid family member 1 , rhomboid family member 1-like , iRhom1 , inactive rhomboid protein 1 , epidermal growth factor receptor, related sequence , epidermal growth factor receptor-related protein , p100hRho , rhomboid family 1 , Rhomboid family member 1 , epidermal growth factor receptor related sequence

416647 Gallus gallus
453783 Pan troglodytes
693423 Macaca mulatta
100494777 Xenopus (Silurana) tropicalis
798402 Danio rerio
64285 Homo sapiens
490101 Canis lupus familiaris
529167 Bos taurus
100328799 Oryctolagus cuniculus
303008 Rattus norvegicus
100137277 Papio anubis
13650 Mus musculus
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