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Human SOX9 Protein expressed in HEK-293 Cells - ABIN2732475
Shi, Chiang, Labhart, Zhao, Yang, Mistretta, Henning, Maity, Mori-Akiyama: Context-specific role of SOX9 in NF-Y mediated gene regulation in colorectal cancer cells. in Nucleic acids research 2015
Data show that SOX9 regulates CEACAM1 (show CEACAM1 Proteins) primarily via Sp1 (show PSG1 Proteins) and ETS1 (show ETS1 Proteins).
Sox9 confers stemness properties of hepatocellular carcinoma through Frizzled-7 mediated Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway.
Data show that the gene encoding the transcription factor SOX9 was identified by a global transcriptomic approach as an HDAC9 (show HDAC9 Proteins) target gene.
SOX9 is a proliferation and stem cell factor (show KITLG Proteins) in hepatocellular carcinoma and possess widespread prognostic significance in different cancer types
Sox9 and Ngn3 (show NEUROG3 Proteins), key transcription factors associated with pancreatic development.
Expression of bone morphogenetic protein (BMP) 4, an upstream stimulator of SOX9, was upregulated by CG.
Xenogeneic implantation of Sox9-overexpressing hUCMSCs embedded in the BMG/fibrin scaffolds promotes the formation of cartilage-like tissue without inducing evident host immune response. Therefore, Sox9-overexpressing hUCMSCs represent a promising cell candidate for cartilage tissue engineering.
KLF15 activates SOX9 expression directly. SOX9 is involved in KLF15 function during chondrogenic differentiation.
Tomo-Seq Identifies SOX9 as a Key Regulator of Cardiac Fibrosis During Ischemic Injury
High SOX9 expression is associated with glioblastoma.
data presented here demonstrate that the 18 bp indel in the porcine SOX9 5'-UTR is of functional importance and may therefore indeed be a causative variation in SOX9 associated traits
HIF-1alpha (show HIF1A Proteins) activates Sox9 expression and enhances Sox9-mediated transcriptional activity.
This resulted in a delay in the birth of OPCs and subsequent developmental aberrations in these cells in the Sox9-deficient mice.
NF-alpha1 is critical for regulating antiproliferation and cell fate determination, through differentiating embryonic stem cells to GFAP (show GFAP Proteins)-positive astrocytes for normal neurodevelopment.
Interactions between the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) and the Kras/ERK (show EPHB2 Proteins)/Foxm1 (show FOXM1 Proteins) pathways are essential to restrict SOX9 expression in basal cells during lung morphogenesis
Hypomethylation in the Sox9 promoter is correlated to increased Sox9 expression in db/db (show LEPR Proteins) IESCs. Although there is increased expression of Sox9 in db/db (show LEPR Proteins) IESCs, the loss of Sox9 transcriptional activation in specific repressors of the Wnt (show WNT2 Proteins) signaling pathway might result in abnormalities in this pathway.
Concluding, this study shows that, in addition to its crucial role in testis development, Sox9, together with Sox8 (show SOX8 Proteins) and coordinately with Dmrt1 (show DMRT1 Proteins), also controls adult testis maintenance.
SOX9 regulation of ETV5 (show ETV5 Proteins) contributes to the control of male fertility
Nuclear factors that bind to genomic regions with "Sertoli Cell Signature" could functionally interact with SOX9; TRIM28 (show TRIM28 Proteins) is a new SOX9 partner in fetal testes.
Down-regulated expression of Sox9 and Dazl (show DAZL Proteins) may play important roles in MBP (show MBP Proteins)-induced testis injury.
Sox9 is positively regulated by mesenchymal Fgf10 (show FGF10 Proteins), a process that requires active Erk (show EPHB2 Proteins) signaling during salivary gland development
TSC1 (show TSC1 Proteins)/TSC2 complex upregulation of OPN (show SPP1 Proteins) expression is mediated by transcription factor SOX9 in an mTOR (show FRAP1 Proteins)-independent manner. Moreover, ablation of OPN (show SPP1 Proteins) by deficient TSC1 (show TSC1 Proteins)/TSC2 complex contributed to inactivation of AKT (show AKT1 Proteins) in TSC (show SLC12A3 Proteins) cells
The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal.
SRY (sex determining region Y)-box 9
, SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)
, transcription factor SOX-10
, SRY (sex-determining region Y)-box 9 protein
, SRY-related HMG-box, gene 9
, transcription factor SOX-9
, SRY-box containing protein 9
, SRY-box containing gene 9
, transcription factor SOX9