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Browse our SPRY2 Proteins (SPRY2)

Full name:
Sprouty Homolog 2 (Drosophila) Proteins (SPRY2)
On www.antibodies-online.com are 13 Sprouty Homolog 2 (Drosophila) (SPRY2) Proteins from 6 different suppliers available. Additionally we are shipping SPRY2 Antibodies (75) and many more products for this protein. A total of 92 SPRY2 products are currently listed.
Synonyms:
hSPRY2, sprouty-2, sprouty2, wu:fk66h11, wu:fk93e11, Xsprouty2, xspry2, Xtsprouty2, zgc:110440
list all proteins Gene Name GeneID UniProt
SPRY2 10253 O43597
SPRY2 24064 Q9QXV8
SPRY2 306141  

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SPRY2 Proteins (SPRY2) by Origin

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More Proteins for SPRY2 Interaction Partners

Xenopus laevis Sprouty Homolog 2 (Drosophila) (SPRY2) interaction partners

  1. Data show that the intracellular domain of PAPC interacts with Sprouty (Spry), and upon binding to PAPC, Spry function is inhibited and PCP signaling is enhanced.

  2. Here we show that Xenopus laevis Sprouty2 (XSpry2) controls the duration of ERK (show MAPK1 Proteins) activity and thereby contributes to the establishment of dorsoventral patterning during mesoderm formation.

Human Sprouty Homolog 2 (Drosophila) (SPRY2) interaction partners

  1. these results establish SPRY2 as a critical negative regulator of BCR (show BCR Proteins)-mediated MAPK-Erk (show MAPK1 Proteins) signaling in chronic lymphocytic leukemia , thereby providing one of the molecular mechanisms to explain the clinical heterogeneity of chronic lymphocytic leukemia.

  2. spry2 can inhibit MM cell growth and survival with a concomitant reduction in phosphorylation of extracellular signal-regulated kinases 1 and 2 in vitro and in vivo.

  3. data suggest that Spry2 acts as a scaffold to bring more pVHL (show VHL Proteins)/associated E3 ligase in proximity of HIF1alpha (show HIF1A Proteins) and increase its ubiquitylation and degradation. This represents a novel action for Spry2 in modulating biological processes regulated by HIFalpha subunits.

  4. MiR (show MLXIP Proteins)-122 could act as a tumor promoter and potentially target Sprouty2. MiR (show MLXIP Proteins)-122 promotes renal cell carcinoma (show MOK Proteins) cell proliferation, migration, and invasion.

  5. miR27b promotes the migration and invasion of gastric cancer cells via inhibition of SPRY2mediated ERK (show EPHB2 Proteins) signaling.

  6. Arg119Trp variant in the SPRY2 gene was identified as the probable IgA nephropathy-causing mutation. This variant is responsible for inhibition of the MAPK/ERK1/2 pathway.

  7. SPRY2, counter to its roles in other cancer settings, promotes glioma cell and tumor growth and cellular resistance to targeted inhibitors of oncogenic RTKs

  8. Data show that proto-oncogene (show RAB1A Proteins) protein B (show LEPREL2 Proteins)-raf (BRAF (show BRAF Proteins)) inhibition induces c-Jun N-terminal kinase (c-JUN) expression and c-JUN (show JUN Proteins) abundance and activation by down-regulating SPRY2/4 protein expression.

  9. Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer

  10. The purpose of this study was to determine whether SPRY2 might have antiinflammatory effects on rheumatoid arthritis fibroblast-like synoviocytes.

Mouse (Murine) Sprouty Homolog 2 (Drosophila) (SPRY2) interaction partners

  1. these results establish SPRY2 as a critical negative regulator of BCR (show BCR Proteins)-mediated MAPK-Erk (show MAPK1 Proteins) signaling in chronic lymphocytic leukemia , thereby providing one of the molecular mechanisms to explain the clinical heterogeneity of chronic lymphocytic leukemia.

  2. In the present study, it is demonstrated that Spry2 and -4 participate in KA induced neurodegeneration possibly through inhibition of ERK (show EPHB2 Proteins) signaling.

  3. Study revealed that suppression of Spry2 expression induced proliferation and differentiation of osteoblastic cells upon bFGF (show FGF2 Proteins) and EGF (show EGF Proteins) stimulation, whereas it diminished proliferation of gingival epithelial cells.

  4. Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer

  5. in embryos with lower Spry2;Spry4 (show SPRY4 Proteins) gene dosages, we observed a non-fusion of original R2 and M1 Shh (show SHH Proteins) signaling domains with consequent formation of a supernumerary tooth primordium from the isolated R2 bud

  6. The data showed enhanced axon outgrowth and improved long-distance axon regeneration in sprouty2 deficient mice

  7. Sprouty2 acts as an inhibitor of CrkL-Rap1 signaling.

  8. we reveal that SPRY2 expression is regulated by FOXO3a (show FOXO3 Proteins) and beta-catenin (show CTNNB1 Proteins) nuclear activity in colon cancer

  9. Spry1 (show SPRY1 Proteins) and Spry2 coordination is required for normal development of the external genitalia in mice

  10. We propose that Sprouty genes(Spry2 and Spry4 (show SPRY4 Proteins)) were implicated during evolution in reduction of the cheek teeth in Muridae, and their deletion can reveal ancestral stages of murine dental evolution.

SPRY2 Protein Profile

Protein Summary

This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.

Alternative names and synonyms associated with SPRY2

  • sprouty homolog 2 (spry2)
  • sprouty homolog 2 (Drosophila) (SPRY2)
  • sprouty homolog 2 (Drosophila) (Spry2)
  • hSPRY2 protein
  • sprouty-2 protein
  • sprouty2 protein
  • wu:fk66h11 protein
  • wu:fk93e11 protein
  • Xsprouty2 protein
  • xspry2 protein
  • Xtsprouty2 protein
  • zgc:110440 protein

Protein level used designations for SPRY2

protein sprouty homolog 2 , sprouty 2 , spry-2

GENE ID SPECIES
335098 Danio rerio
449471 Xenopus (Silurana) tropicalis
100173576 Pongo abelii
398313 Xenopus laevis
10253 Homo sapiens
485504 Canis lupus familiaris
539090 Bos taurus
24064 Mus musculus
306141 Rattus norvegicus
395584 Gallus gallus
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