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Data show that the intracellular domain of PAPC interacts with Sprouty (Spry), and upon binding to PAPC, Spry function is inhibited and PCP signaling is enhanced.
Here we show that Xenopus laevis Sprouty2 (XSpry2) controls the duration of ERK (show MAPK1 Proteins) activity and thereby contributes to the establishment of dorsoventral patterning during mesoderm formation.
data suggest that Spry2 acts as a scaffold to bring more pVHL (show VHL Proteins)/associated E3 ligase in proximity of HIF1alpha (show HIF1A Proteins) and increase its ubiquitylation and degradation. This represents a novel action for Spry2 in modulating biological processes regulated by HIFalpha subunits.
MiR (show MLXIP Proteins)-122 could act as a tumor promoter and potentially target Sprouty2. MiR (show MLXIP Proteins)-122 promotes renal cell carcinoma (show MOK Proteins) cell proliferation, migration, and invasion.
miR27b promotes the migration and invasion of gastric cancer cells via inhibition of SPRY2mediated ERK (show EPHB2 Proteins) signaling.
Arg119Trp variant in the SPRY2 gene was identified as the probable IgA nephropathy-causing mutation. This variant is responsible for inhibition of the MAPK/ERK1/2 pathway.
SPRY2, counter to its roles in other cancer settings, promotes glioma cell and tumor growth and cellular resistance to targeted inhibitors of oncogenic RTKs
Data show that proto-oncogene (show RAB1A Proteins) protein B (show LEPREL2 Proteins)-raf (BRAF (show BRAF Proteins)) inhibition induces c-Jun N-terminal kinase (c-JUN) expression and c-JUN (show JUN Proteins) abundance and activation by down-regulating SPRY2/4 protein expression.
Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer
The purpose of this study was to determine whether SPRY2 might have antiinflammatory effects on rheumatoid arthritis fibroblast-like synoviocytes.
miR21 may represent a negative regulator involved in the downregulation of SPRY2 in MM.
No association between SPRY2, single-nucleotide polymorphisms, and nonsyndromic cleft lip with or without cleft palate risk were observed in this cohort of patients.
In the present study, it is demonstrated that Spry2 and -4 participate in KA induced neurodegeneration possibly through inhibition of ERK (show EPHB2 Proteins) signaling.
Study revealed that suppression of Spry2 expression induced proliferation and differentiation of osteoblastic cells upon bFGF (show FGF2 Proteins) and EGF (show EGF Proteins) stimulation, whereas it diminished proliferation of gingival epithelial cells.
in embryos with lower Spry2;Spry4 (show SPRY4 Proteins) gene dosages, we observed a non-fusion of original R2 and M1 Shh (show SHH Proteins) signaling domains with consequent formation of a supernumerary tooth primordium from the isolated R2 bud
The data showed enhanced axon outgrowth and improved long-distance axon regeneration in sprouty2 deficient mice
Sprouty2 acts as an inhibitor of CrkL-Rap1 signaling.
we reveal that SPRY2 expression is regulated by FOXO3a (show FOXO3 Proteins) and beta-catenin (show CTNNB1 Proteins) nuclear activity in colon cancer
Spry1 (show SPRY1 Proteins) and Spry2 coordination is required for normal development of the external genitalia in mice
We propose that Sprouty genes(Spry2 and Spry4 (show SPRY4 Proteins)) were implicated during evolution in reduction of the cheek teeth in Muridae, and their deletion can reveal ancestral stages of murine dental evolution.
conjunctival epithelial Spry1 (show SPRY1 Proteins) and Spry2 redundantly promote eyelid closure.
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.
protein sprouty homolog 2
, sprouty 2