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XBP1 does not act as a direct activator of STAT3 phosphorylation. Hence, in regenerati (show DDR1 ELISA Kits)ng livers, XBP1 deficiency most likely affects STAT3 phosphorylation in an indirect manner, possibly related to unresolved ER stress.
reciprocal regulation of Pin1 (show PIN1 ELISA Kits) and XBP1s is associated with the activation of oncogenic pathways, and the relationship of PIN1 (show PIN1 ELISA Kits) and XBP1 may be an attractive target for novel therapy in cancers
Our data indicate that reduced response of IRE1alpha (show ERN1 ELISA Kits)/Xbp-1 signaling pathway to bortezomib may contribute to drug resistance in myeloma cells
XBP1 regulates VEGF-mediated cardiac angiogenesis.
XBP1s expression in mouse and human fibroblasts is critical for TiAl6 V4 particle-induced RANKL (show TNFSF11 ELISA Kits) expression and osteolysis
The molecular-level exploration into the signaling mechanism was investigated for the respective role of the residues from the two important proteins from Homo sapiens ERalpha (show ESR1 ELISA Kits) and XBP-1 (bZIP domain)) for breast tumors metastasis via proliferation. It further dealt with the analysis and examination of the changes that are caused due to the point mutation K214R in the ERalpha (show ESR1 ELISA Kits) protein.
plasma exposure resulted in expression of unfolded protein response (UPR) proteins such as glucoserelated protein 78 (GRP78 (show HSPA5 ELISA Kits)), protein kinase (show CDK7 ELISA Kits) R (PKR (show PKLR ELISA Kits))like ER kinase (PERK (show EIF2AK3 ELISA Kits)), and inositolrequiring enzyme 1 (IRE1 (show ERN1 ELISA Kits)). Elevated expression of spliced Xbox binding protein 1 (XBP1) and CCAAT/enhancerbinding protein homologous protein (CHOP (show DDIT3 ELISA Kits)) further confirmed that ROS (show ROS1 ELISA Kits) generatedby NTGP induces apoptosis through the ER stress
Data suggest that XBP1 is a major component in endocrine pancreas that is crucial for glucose homeostasis and lipid metabolism; drugs targeting XBP1 signaling and endoplasmic reticulum stress/unfolded protein response in endocrine pancreas are potential approaches for treatment of disorders of glucose metabolism.
High XBP1 expression is associated with glioma.
Overexpression of X-Box Binding Protein 1 (XBP1) Correlates to Poor Prognosis and Up-Regulation of PI3K (show PIK3CA ELISA Kits)/mTOR (show FRAP1 ELISA Kits) in Human Osteosarcoma
XBP1 expression regulates the unfolded protein response, acute-phase response, and DDR (show DDR1 ELISA Kits) in hepatocytes. In regenerating livers, XBP1 deficiency leads to endoplasmic reticulum stress and DNA damage.
Ire1alpha (show ERN1 ELISA Kits)-Xbp1s and associated molecular targets link ER stress in arcuate Pomc (show POMC ELISA Kits) neurons to aspects of normal energy and glucose homeostasis.
Overexpression of active XBP1 partially reversed 4mu8C-induced anomalies in tight junctions.
results reveal that XBP1s reduces hepatic lipogenic gene expression and improves hepatosteatosis in mouse models of obesity and insulin (show INS ELISA Kits) resistance, which leads us to conclude that XBP1s has anti-lipogenic properties in the liver.
Study used three experimental approaches to enhance the IKKbeta (show IKBKB ELISA Kits) activity in the liver of obese mice and observed increased XBP1s activity, reduced endoplasmic reticulum stress, and a significant improvement in insulin (show INS ELISA Kits) sensitivity and consequently in glucose homeostasis.
Findings indicate that PERK (show EIF2AK3 ELISA Kits) kinase-activating transcription factor 4 (ATF4 (show ATF4 ELISA Kits)) pathway affected the efficiency of X-box binding protein 1 (XBP1) mRNA splicing by regulating inositol-requiring enzyme 1alpha (IRE1alpha (show ERN1 ELISA Kits)) expression.
Gene expression analysis revealed that XBP1 regulates a group of memory-related genes, highlighting BDNF (show BDNF ELISA Kits), as a key component in memory consolidation.
XBP1s can regulate Wnt10b (show WNT10B ELISA Kits) by a post-transcriptional mechanism through directly inducing microRNA-148a.
analyzed XBP1 level and location to explore the effect of ER stress on oocyte maturation and developmental competency of porcine embryos in an in vitro culture system
Knock-down of XBP1 enhanced endoplasmic reticulum stress-mediated cell death in porcine embryonic fibroblasts.
Exposure of endothelial cells to VEGF (show VEGFA ELISA Kits), high glucose, or hydrogen peroxide up-regulated the XBP1/IRE1 alpha (show ERN1 ELISA Kits) and ATF6 (show ATF6 ELISA Kits) arms of the unfolded protein response compared with untreated cells.
Expression of xbp1 is significantly upregulated in the liver of Cdipt (show CDIPT ELISA Kits)-deficient zebrafish due to persistent endoplasmic reticulum stress. Cdipt (show CDIPT ELISA Kits)-deficient zebrafish exhibits hepatic lipid accumulation.
zebrafish XBP-1 spliced form not only activates genes responsible for protein folding, transporting, glycosylation and Endoplasmic Reticulum associated degradation but also activates anti-apoptosis signal via IGF1 (show IGF1 ELISA Kits)/Akt (show AKT1 ELISA Kits) pathway in unfolded protein
XBP1 might function as an inhibitor of mesodermal and neural tissue formation by acting either as transcriptional activator or as repressor.
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.
X-box binding protein 1 pseudogene 1
, X-box binding protein pseudogene 1
, X-box binding protein 1
, X-box-binding protein 1
, tax-responsive element-binding protein 5
, tax-responsive element-binding protein 5 homolog
, hepatocarcinogenesis-related transcription factor
, X-box binding protein 1B