Browse our XBP1 Proteins (XBP1)

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X-Box Binding Protein 1 Proteins (XBP1)
On are 8 X-Box Binding Protein 1 (XBP1) Proteins from 4 different suppliers available. Additionally we are shipping XBP1 Antibodies (218) and XBP1 Kits (35) and many more products for this protein. A total of 277 XBP1 products are currently listed.
cb918, D11Ertd39e, HTF, id:ibd1195, TREB-5, TREB5, trebf, wu:fb02h05, wu:fb63f10, XBP-1, xbp1, xbp1a, xbp1b, XBP1P1, XBP2, XBPP1, xXBP1
list all proteins Gene Name GeneID UniProt
XBP1 7494 P17861
Mouse XBP1 XBP1 22433 O35426
XBP1 289754 Q9R1S4

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XBP1 Proteins (XBP1) by Origin

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More Proteins for XBP1 Interaction Partners

Human X-Box Binding Protein 1 (XBP1) interaction partners

  1. The findings indicate that IRE1 (show ERN1 Proteins)-XBP1 downregulation distinguishes germinal center B-cell-like diffuse large B-cell lymphoma (DLBCL) from other DLBCL subtypes and contributes to tumor growth.

  2. XBP1 does not act as a direct activator of STAT3 phosphorylation. Hence, in regenerati (show DDR1 Proteins)ng livers, XBP1 deficiency most likely affects STAT3 phosphorylation in an indirect manner, possibly related to unresolved ER stress.

  3. reciprocal regulation of Pin1 (show PIN1 Proteins) and XBP1s is associated with the activation of oncogenic pathways, and the relationship of PIN1 (show PIN1 Proteins) and XBP1 may be an attractive target for novel therapy in cancers

  4. Our data indicate that reduced response of IRE1alpha (show ERN1 Proteins)/Xbp-1 signaling pathway to bortezomib may contribute to drug resistance in myeloma cells

  5. XBP1 regulates VEGF-mediated cardiac angiogenesis.

  6. XBP1s expression in mouse and human fibroblasts is critical for TiAl6 V4 particle-induced RANKL (show TNFSF11 Proteins) expression and osteolysis

  7. The molecular-level exploration into the signaling mechanism was investigated for the respective role of the residues from the two important proteins from Homo sapiens ERalpha (show ESR1 Proteins) and XBP-1 (bZIP domain)) for breast tumors metastasis via proliferation. It further dealt with the analysis and examination of the changes that are caused due to the point mutation K214R in the ERalpha (show ESR1 Proteins) protein.

  8. plasma exposure resulted in expression of unfolded protein response (UPR) proteins such as glucoserelated protein 78 (GRP78 (show HSPA5 Proteins)), protein kinase (show CDK7 Proteins) R (PKR (show PKLR Proteins))like ER kinase (PERK (show EIF2AK3 Proteins)), and inositolrequiring enzyme 1 (IRE1 (show ERN1 Proteins)). Elevated expression of spliced Xbox binding protein 1 (XBP1) and CCAAT/enhancerbinding protein homologous protein (CHOP (show DDIT3 Proteins)) further confirmed that ROS (show ROS1 Proteins) generatedby NTGP induces apoptosis through the ER stress

  9. Data suggest that XBP1 is a major component in endocrine pancreas that is crucial for glucose homeostasis and lipid metabolism; drugs targeting XBP1 signaling and endoplasmic reticulum stress/unfolded protein response in endocrine pancreas are potential approaches for treatment of disorders of glucose metabolism.

  10. High XBP1 expression is associated with glioma.

Mouse (Murine) X-Box Binding Protein 1 (XBP1) interaction partners

  1. The findings indicate that IRE1 (show ERN1 Proteins)-XBP1 downregulation distinguishes germinal center B-cell-like diffuse large B-cell lymphoma (DLBCL) from other DLBCL subtypes and contributes to tumor growth.

  2. However, depletion of XBP1 and ATF6 (show ATF6 Proteins), alone or in combination, prevented autophagy induction and significantly enhanced Japanese encephalitis virus-induced cell death.

  3. XBP1 expression regulates the unfolded protein response, acute-phase response, and DDR (show DDR1 Proteins) in hepatocytes. In regenerating livers, XBP1 deficiency leads to endoplasmic reticulum stress and DNA damage.

  4. Ire1alpha (show ERN1 Proteins)-Xbp1s and associated molecular targets link ER stress in arcuate Pomc (show POMC Proteins) neurons to aspects of normal energy and glucose homeostasis.

  5. XBP1 regulates VEGF-mediated cardiac angiogenesis.

  6. Overexpression of active XBP1 partially reversed 4mu8C-induced anomalies in tight junctions.

  7. XBP1s expression in mouse and human fibroblasts is critical for TiAl6 V4 particle-induced RANKL (show TNFSF11 Proteins) expression and osteolysis

  8. results reveal that XBP1s reduces hepatic lipogenic gene expression and improves hepatosteatosis in mouse models of obesity and insulin (show INS Proteins) resistance, which leads us to conclude that XBP1s has anti-lipogenic properties in the liver.

  9. Study used three experimental approaches to enhance the IKKbeta (show IKBKB Proteins) activity in the liver of obese mice and observed increased XBP1s activity, reduced endoplasmic reticulum stress, and a significant improvement in insulin (show INS Proteins) sensitivity and consequently in glucose homeostasis.

  10. Findings indicate that PERK (show EIF2AK3 Proteins) kinase-activating transcription factor 4 (ATF4 (show ATF4 Proteins)) pathway affected the efficiency of X-box binding protein 1 (XBP1) mRNA splicing by regulating inositol-requiring enzyme 1alpha (IRE1alpha (show ERN1 Proteins)) expression.

Pig (Porcine) X-Box Binding Protein 1 (XBP1) interaction partners

  1. analyzed XBP1 level and location to explore the effect of ER stress on oocyte maturation and developmental competency of porcine embryos in an in vitro culture system

  2. Knock-down of XBP1 enhanced endoplasmic reticulum stress-mediated cell death in porcine embryonic fibroblasts.

Cow (Bovine) X-Box Binding Protein 1 (XBP1) interaction partners

  1. Exposure of endothelial cells to VEGF (show VEGFA Proteins), high glucose, or hydrogen peroxide up-regulated the XBP1/IRE1 alpha (show ERN1 Proteins) and ATF6 (show ATF6 Proteins) arms of the unfolded protein response compared with untreated cells.

Zebrafish X-Box Binding Protein 1 (XBP1) interaction partners

  1. Expression of xbp1 is significantly upregulated in the liver of Cdipt (show CDIPT Proteins)-deficient zebrafish due to persistent endoplasmic reticulum stress. Cdipt (show CDIPT Proteins)-deficient zebrafish exhibits hepatic lipid accumulation.

  2. zebrafish XBP-1 spliced form not only activates genes responsible for protein folding, transporting, glycosylation and Endoplasmic Reticulum associated degradation but also activates anti-apoptosis signal via IGF1 (show IGF1 Proteins)/Akt (show AKT1 Proteins) pathway in unfolded protein

Xenopus laevis X-Box Binding Protein 1 (XBP1) interaction partners

  1. XBP1 might function as an inhibitor of mesodermal and neural tissue formation by acting either as transcriptional activator or as repressor.

XBP1 Protein Profile

Protein Summary

This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.

Alternative names and synonyms associated with XBP1

  • X-box binding protein 1 (xbp1)
  • X-box binding protein 1 (XBP1)
  • uncharacterized LOC100719734 (LOC100719734)
  • X box-binding protein active isoform (LOC100037692)
  • X-box binding protein 1 (Xbp1)
  • cb918 protein
  • D11Ertd39e protein
  • HTF protein
  • id:ibd1195 protein
  • TREB-5 protein
  • TREB5 protein
  • trebf protein
  • wu:fb02h05 protein
  • wu:fb63f10 protein
  • XBP-1 protein
  • xbp1 protein
  • xbp1a protein
  • xbp1b protein
  • XBP1P1 protein
  • XBP2 protein
  • XBPP1 protein
  • xXBP1 protein

Protein level used designations for X-Box Binding Protein 1 Proteins (XBP1)

X-box binding protein 1 pseudogene 1 , X-box binding protein pseudogene 1 , X-box binding protein 1 , X-box-binding protein 1 , tax-responsive element-binding protein 5 , tax-responsive element-binding protein 5 homolog , XBP-1 , hepatocarcinogenesis-related transcription factor , X-box binding protein 1B

407858 Xenopus (Silurana) tropicalis
458735 Pan troglodytes
654272 Takifugu rubripes
100719734 Cavia porcellus
100037692 Ovis aries
7494 Homo sapiens
22433 Mus musculus
100217386 Sus scrofa
541236 Bos taurus
289754 Rattus norvegicus
140614 Danio rerio
380215 Xenopus laevis
416918 Gallus gallus
477532 Canis lupus familiaris
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