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Rat (Rattus) KL Protein expressed in Escherichia coli (E. coli) - ABIN2123130
Wu, Lv, Chen, Ma, Shao, Wang: The function of miR-199a-5p/Klotho regulating TLR4/NF-?B p65/NGAL pathways in rat mesangial cells cultured with high glucose and the mechanism. in Molecular and cellular endocrinology 2015
serum FGF23 (show FGF23 Proteins) was positively associated with coronary artery calcification in women and serum alpha-Klotho was positively associated with aortic valve calcification in men, independent of the confounding variables
The -395A allele of the KLOTHO gene may be a protective genetic factor for hypertension in the Chinese population.
The -395A allele carriers of the Klotho gene were correlated with lower risk of metabolic syndrome in a Chinese elderly population.
Full-length, membrane-bound Klotho is not expressed in healthy or uraemic human vascular tissue.
analysis of longitudinal associations between baseline s-klotho and FGF23 (show FGF23 Proteins) concentrations and mortality reveals that FGF23 (show FGF23 Proteins), but not klotho, may have a role in excess (show RCC1 Proteins) mortality in cardiovascular disease in those with normal kidney function
The preliminary investigation into the correlation between markers of osteo- and sarcopenia and Klotho demonstrated a decreased Klotho concentration in beta-TM patients and a higher probability of having had fragility fractures.
Inhibition of mTOR (show FRAP1 Proteins) signaling ameliorates vascular calcification via Klotho upregulation.
Lower expression of Klotho is associated with liver cancer.
MPV was significantly correlated with log(FGF21 (show FGF21 Proteins)) (R=-0.167, p<0.05) and log(FGF23 (show FGF23 Proteins)) (R=0.351, p<0.001) but not with log(alpha-Klotho).
G-395A polymorphism of Klotho gene could increase the risk of colorectal cancer
Klotho deficiency promoted HFD-induced arterial stiffening and hypertension via downregulation of AMPKalpha (show GRK4 Proteins) activity.
level of spontaneous remyelination was increased approximately two-fold in Klotho-overexpressing mice following cuprizone-induced demyelination.
data highlight the importance of ASK1 (show MAP3K5 Proteins)/p38 MAPK (show MAPK14 Proteins) pathway in the brain and identify Klotho as a possible anti-oxidant effector
Klotho ameliorates kidney injury and fibrosis and normalizes blood pressure by targeting the renin (show REN Proteins)-angiotensin system.
Injection of klotho protein results in hematopoietic changes opposite to the ones observed in Klotho(-/-) mice.
Sodium bicarbonate administration has a favorable influence on vascular calcification and early death of klotho-deficient mice.
Data suggest that the level of expression of Klotho in pancreatic beta-cells regulates apoptosis; low expression (halplodeficiency of Klotho) promotes apoptosis/type 1 diabetes; beta-cell-specific overexpression prevents apoptosis/type 1 diabetes.
p16(INK4a) plays a previously unrecognized role in downregulating alpha-klotho expression during ageing.
Klotho deficiency-induced arterial stiffening may involve aldosterone-mediated upregulation of scleraxis and induction of autophagy, which led to increased collagen-1 expression and decreased elastin (show ELN Proteins) levels, respectively.
significant expression of FGF23 (show FGF23 Proteins) and KL within the growth plate and adjacent tissues imply a potential local role of FGF23 (show FGF23 Proteins) in chondrocyte differentiation and tissue mineralization.
This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.
, kit ligand
, secreted form of Klotho protein