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Browse our Klotho Proteins (KL)

Full name:
Klotho Proteins (KL)
On are 12 Klotho (KL) Proteins from 6 different suppliers available. Additionally we are shipping Klotho Antibodies (85) and Klotho Kits (48) and many more products for this protein. A total of 159 Klotho products are currently listed.
alpha-kl, Kitl, KL, LOC100223456
list all proteins Gene Name GeneID UniProt
KL 9365 Q9UEF7
KL 16591 O35082
KL 83504 Q9Z2Y9

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Klotho Proteins (KL) by Origin

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Top referenced Klotho Proteins

  1. Rat (Rattus) KL Protein expressed in Escherichia coli (E. coli) - ABIN2123130 : Wu, Lv, Chen, Ma, Shao, Wang: The function of miR-199a-5p/Klotho regulating TLR4/NF-?B p65/NGAL pathways in rat mesangial cells cultured with high glucose and the mechanism. in Molecular and cellular endocrinology 2015 (PubMed)

More Proteins for Klotho Interaction Partners

Human Klotho (KL) interaction partners

  1. FGF23 (show FGF23 Proteins) affected NO synthesis and oxidative stress in human coronary artery endothelial cells are modulated by Klotho.

  2. Conversely, siRNA-mediated Klotho silencing up-regulated Egr-1 (show EGR1 Proteins), FN, and Col (show HDAC1 Proteins) I expression and the p-Smad3/Smad3 (show SMAD3 Proteins) ratio. Moreover, the effects of si-Klotho on Egr-1 (show EGR1 Proteins) expression were abolished by the TGF-beta1 (show TGFB1 Proteins) inhibitor SB-431542. Klotho overexpression can prevent mesangial ECM (show MMRN1 Proteins) production in high-glucose-treated human MCs (show SMCP Proteins), an effect that has been partially attributed to Egr-1 (show EGR1 Proteins) down-regulation facilitated by TGF-beta1 (show TGFB1 Proteins)/Smad3 (show SMAD3 Proteins) s...

  3. Klotho levels were higher in acute kidney injury patients and females and lower in end stage renal disease patients than in healthy adults and patients with moderate chronic kidney disease.

  4. Genetic polymorphisms such as the G-395A polymorphism in the promoter region of the Klotho gene have been associated with the development of essential hypertension.

  5. Secreted and cleaved sKlotho and FGF23 (show FGF23 Proteins) are detected in CSF (show CSF2 Proteins) and plasma, and the protein levels are significantly higher in plasma in children with suspected CNS disease

  6. Klotho was demonstrated to act as a potent tumor suppressor in human ovarian cancer cells. Reduced Klotho expression was detected in the specimens of patients with ovarian cancer, and overexpression of Klotho significantly inhibited cell proliferation of human ovarian cancer cells.

  7. Any polymorphism altering the function of klotho gene may result with stone formation. We found that there are more GG sequences of G395A gene in patients with urinary tract stone disease. That may be a polymorphism of klotho gene which results with stone formation.

  8. There is no association between the KL polymorphism and FGF23 (show FGF23 Proteins) concentration in patients undergoing long-term Hemodialysis.

  9. The rs3752472 and rs650439 single-nucleotide polymorphisms of Klotho gene are related to the risk of calcium oxalate stones in Xinjiang Uyghurpeople, and might be one of the risk factors

  10. There was no change in circulating FGF23 and Klotho concentrations after PTX in hemodialysis patients given postoperative calcium supplements and/or vitamin D analogue. Serum FGF23 concentrations pre-PTX and at days 5 and 90 after PTX were inversely related to serum calcium concentrations.

Mouse (Murine) Klotho (KL) interaction partners

  1. Klotho gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (show GRK4 Proteins)-RUNX2 (show RUNX2 Proteins) pathway.

  2. The effects were abolished by using pharmacological inhibition of PI3K/Akt (show AKT1 Proteins) with LY294002 and paralleled by transfecting DCs with klotho siRNA. In conclusion, the regulation of klotho sensitive DC function by IGF-1 (show IGF1 Proteins) or insulin (show INS Proteins) is mediated through PI3K/Akt (show AKT1 Proteins) signaling pathway in BMDCs.

  3. Klotho can modulate inflammation via PDLIM2 (show PDLIM2 Proteins)/NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins) pathway in cyclosporine A-induced nephropathy.

  4. the histological malformation in periodontal tissues in alphaKlotho-deficient mice appears to be due to not only increased concentration of inorganic phosphate but also disrupted alphaklotho/FGF23 (show FGF23 Proteins) signaling

  5. Results show that Klotho regulates adrenal CYP11B2 (show CYP11B2 Proteins) expression. Klotho deficiency-induced spontaneous hypertension and kidney damage may be partially attributed to the upregulation of CYP11B2 (show CYP11B2 Proteins) expression and aldosterone synthesis.

  6. Aberrant Klotho expression contributes to systemic chronic inflammation in Klotho-/- mice.

  7. Thus, higher levels of FGF23 (show FGF23 Proteins) in kl/kl mouse may have a role to increase TNF-alpha (show TNF Proteins) production in would lesion independently of alpha-Klotho protein, and impair granulation formation and delay wound healing.

  8. Klotho protein protects against diabetic nephropathy through multiple pathways.

  9. In vitro studies showed interleukin-12 regulation on Klotho, while Klotho also acted as an inhibitor on interleukin-12, indicating the potential of Klotho for preserving pancreatic beta-cell function in diabetes.

  10. Studies indicate that defect in Klotho gene expression results in a phenotype of premature aging.

Pig (Porcine) Klotho (KL) interaction partners

  1. Klotho gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (show GRK4 Proteins)-RUNX2 (show RUNX2 Proteins) pathway.

  2. significant expression of FGF23 (show FGF23 Proteins) and KL within the growth plate and adjacent tissues imply a potential local role of FGF23 (show FGF23 Proteins) in chondrocyte differentiation and tissue mineralization.

Klotho (KL) Protein Profile

Protein Summary

This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.

Alternative names and synonyms associated with Klotho (KL)

  • klotho (KL)
  • klotho (LOC100223456)
  • klotho (kl)
  • klotho (LOC100533542)
  • klotho (Kl)
  • Klotho (Kl)
  • Klotho-like (LOC100356074)
  • alpha-kl protein
  • Kitl protein
  • KL protein
  • LOC100223456 protein

Protein level used designations for Klotho Proteins (KL)

klotho , kit ligand , secreted form of Klotho protein

467257 Pan troglodytes
100009028 Oryctolagus cuniculus
100223456 Taeniopygia guttata
100490988 Xenopus (Silurana) tropicalis
100533542 Aplysia californica
9365 Homo sapiens
16591 Mus musculus
83504 Rattus norvegicus
100685604 Canis lupus familiaris
100519728 Sus scrofa
784635 Bos taurus
100714519 Cavia porcellus
418909 Gallus gallus
101110249 Ovis aries
100356074 Oryctolagus cuniculus
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