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Browse our Klotho Proteins (KL)

Full name:
Klotho Proteins (KL)
On are 13 Klotho (KL) Proteins from 7 different suppliers available. Additionally we are shipping Klotho Antibodies (95) and Klotho Kits (40) and many more products for this protein. A total of 163 Klotho products are currently listed.
alpha-kl, Kitl, KL, LOC100223456
list all proteins Gene Name GeneID UniProt
KL 9365 Q9UEF7
KL 16591 O35082
KL 83504 Q9Z2Y9

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Klotho Proteins (KL) by Origin

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Top referenced Klotho Proteins

  1. Rat (Rattus) KL Protein expressed in Escherichia coli (E. coli) - ABIN2123130 : Wu, Lv, Chen, Ma, Shao, Wang: The function of miR-199a-5p/Klotho regulating TLR4/NF-?B p65/NGAL pathways in rat mesangial cells cultured with high glucose and the mechanism. in Molecular and cellular endocrinology 2015 (PubMed)

More Proteins for Klotho Interaction Partners

Human Klotho (KL) interaction partners

  1. Data suggest that down-regulation of serum Klotho level may play role in development of atherosclerosis and endothelial dysfunction in subjects with type 1 diabetes.

  2. The data suggest that secreted Klotho protein attenuates the osteogenic differentiation of human bone marrow mesenchymal stem cells in vitro through FGFR1 (show FGFR1 Proteins)/ERK (show EPHB2 Proteins) signaling.

  3. Data revealed the existence of a moderating effect between Klotho and STC1 (show STC1 Proteins), where Klotho may inhibit thyroid tumor progression by inhibiting the tumor marker level of STC1 (show STC1 Proteins).

  4. Among cardiac patients with preserved left ventricular ejection fraction, serum alpha-Klotho concentrations but not FGF23 (show FGF23 Proteins) concentrations were negatively associated with diastolic dysfunction.

  5. KLOTHO G-395A polymorphism associates with reduced cognitive impairment in a sample of Chinese nonagenarians and centenarians.

  6. serum FGF23 (show FGF23 Proteins) was positively associated with coronary artery calcification in women and serum alpha-Klotho was positively associated with aortic valve calcification in men, independent of the confounding variables

  7. The -395A allele of the KLOTHO gene may be a protective genetic factor for hypertension in the Chinese population.

  8. The -395A allele carriers of the Klotho gene were correlated with lower risk of metabolic syndrome in a Chinese elderly population.

  9. Full-length, membrane-bound Klotho is not expressed in healthy or uraemic human vascular tissue.

  10. analysis of longitudinal associations between baseline s-klotho and FGF23 (show FGF23 Proteins) concentrations and mortality reveals that FGF23 (show FGF23 Proteins), but not klotho, may have a role in excess (show RCC1 Proteins) mortality in cardiovascular disease in those with normal kidney function

Mouse (Murine) Klotho (KL) interaction partners

  1. Inhibition of mTOR (show FRAP1 Proteins) signaling ameliorates vascular calcification via Klotho upregulation.

  2. Klotho deficiency promoted HFD-induced arterial stiffening and hypertension via downregulation of AMPKalpha (show GRK4 Proteins) activity.

  3. level of spontaneous remyelination was increased approximately two-fold in Klotho-overexpressing mice following cuprizone-induced demyelination.

  4. data highlight the importance of ASK1 (show MAP3K5 Proteins)/p38 MAPK (show MAPK14 Proteins) pathway in the brain and identify Klotho as a possible anti-oxidant effector

  5. Klotho ameliorates kidney injury and fibrosis and normalizes blood pressure by targeting the renin (show REN Proteins)-angiotensin system.

  6. Injection of klotho protein results in hematopoietic changes opposite to the ones observed in Klotho(-/-) mice.

  7. Sodium bicarbonate administration has a favorable influence on vascular calcification and early death of klotho-deficient mice.

  8. Data suggest that the level of expression of Klotho in pancreatic beta-cells regulates apoptosis; low expression (halplodeficiency of Klotho) promotes apoptosis/type 1 diabetes; beta-cell-specific overexpression prevents apoptosis/type 1 diabetes.

  9. p16(INK4a) plays a previously unrecognized role in downregulating alpha-klotho expression during ageing.

  10. Klotho deficiency-induced arterial stiffening may involve aldosterone-mediated upregulation of scleraxis and induction of autophagy, which led to increased collagen-1 expression and decreased elastin (show ELN Proteins) levels, respectively.

Pig (Porcine) Klotho (KL) interaction partners

  1. significant expression of FGF23 (show FGF23 Proteins) and KL within the growth plate and adjacent tissues imply a potential local role of FGF23 (show FGF23 Proteins) in chondrocyte differentiation and tissue mineralization.

Klotho (KL) Protein Profile

Protein Summary

This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.

Alternative names and synonyms associated with Klotho (KL)

  • klotho (KL)
  • klotho (LOC100223456)
  • klotho (kl)
  • klotho (LOC100533542)
  • klotho (Kl)
  • Klotho (Kl)
  • Klotho-like (LOC100356074)
  • alpha-kl protein
  • Kitl protein
  • KL protein
  • LOC100223456 protein

Protein level used designations for Klotho Proteins (KL)

klotho , kit ligand , secreted form of Klotho protein

467257 Pan troglodytes
100009028 Oryctolagus cuniculus
100223456 Taeniopygia guttata
100490988 Xenopus (Silurana) tropicalis
100533542 Aplysia californica
9365 Homo sapiens
16591 Mus musculus
83504 Rattus norvegicus
100685604 Canis lupus familiaris
100519728 Sus scrofa
784635 Bos taurus
100714519 Cavia porcellus
418909 Gallus gallus
101110249 Ovis aries
100356074 Oryctolagus cuniculus
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