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Rat (Rattus) KL Protein expressed in Escherichia coli (E. coli) - ABIN2123130
Wu, Lv, Chen, Ma, Shao, Wang: The function of miR-199a-5p/Klotho regulating TLR4/NF-?B p65/NGAL pathways in rat mesangial cells cultured with high glucose and the mechanism. in Molecular and cellular endocrinology 2015
Down-Regulation of Soluble alpha-Klotho is Associated with Reduction in Serum Irisin (show FNDC5 Proteins) Levels in Chronic Obstructive Pulmonary Disease. soluble a-klotho is one possible factor involved in reduced irisin (show FNDC5 Proteins) release from skeletal muscle
Klotho is a co-receptor for FGF23 (show FGF23 Proteins). Together they play an important role in bone mineral and vitamin D metabolism. In chronic kidney disease, disturbances in bone metabolism increase cardiovascular risk. In the kidney, klotho induces phosphaturia. Klotho levels drop in chronic kidney disease. It inhibits vascular calcification. Review.
A single copy of klotho allele KL-VS is associated with longevity, better health, increased cognition, and bigger regional brain volume.
Review of Klotho function and dysfunction in mice and humans. [Review Article]
The Klotho KL-VS variant is associated with an increase in the incidence of dementia in older men, in a dose-dependent fashion (intermediate for heterozygosis and highest for homozygosis).
Our findings provide the first evidence that alpha-Klotho is significantly decreased in the microvasculature in systemic sclerosis skin
indicates an inverse interrelationship between inflammation and Klotho in atherosclerosis
Administration of soluble klotho significantly reduced obstruction-induced renal fibrosis in wild-type mice, but not in Trpc6 (show TRPC6 Proteins) knockout mice, indicating that klotho and TRPC6 (show TRPC6 Proteins) inhibition act in the same pathway to protect against obstruction-induced renal fibrosis.
The role of Klotho protein in aging and central nervous system pathology is reviewed.
These results support the notion that sialogangliosides and lipid rafts are membrane receptors for sKlotho and that the KL1 (show KITLG Proteins) domain is sufficient for the tested biologic activities.
Klotho is a novel regulator of postnatal neurogenesis affecting neural stem cell proliferation and maturation sufficient to impact hippocampal-dependent spatial memory function.
Reduced Klotho expression aggravates tacrolimus-induced renal injury via the PI3K-Akt (show AKT1 Proteins)-FoxO (show FOXO3 Proteins) pathway.
Two distinct isoforms of soluble Klotho appear to play counter-regulatory roles in cardiac fibrogenic responses.
Klotho regulates adipogenic differentiation in adipose-derived stem cells, likely via inhibition of TGFbeta1 (show TGFB1 Proteins) and activation of PPAR-gamma (show PPARG Proteins).
Overexpression of Klotho inhibits the differentiation of RAW264.7 cells into osteoclasts.
Data suggest that klotho affects cognition, at least in part, by regulating hippocampal synaptic plasticity.
Adiponectin alters calcium and phosphate balance and renal mineral excretion, in part, through klotho.
Klotho in bone is crucial for inducing FGF23 (show FGF23 Proteins) production upon renal failure
Activated HAT activity of p300 (show EP300 Proteins) modulates AV calcification through osteogenic transdifferentiation of VICs with Klotho modulation.
Klotho gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (show GRK4 Proteins)-RUNX2 (show RUNX2 Proteins) pathway.
significant expression of FGF23 (show FGF23 Proteins) and KL within the growth plate and adjacent tissues imply a potential local role of FGF23 (show FGF23 Proteins) in chondrocyte differentiation and tissue mineralization.
This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.
, kit ligand
, secreted form of Klotho protein