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Rat (Rattus) KL Protein expressed in Escherichia coli (E. coli) - ABIN2123130
Wu, Lv, Chen, Ma, Shao, Wang: The function of miR-199a-5p/Klotho regulating TLR4/NF-?B p65/NGAL pathways in rat mesangial cells cultured with high glucose and the mechanism. in Molecular and cellular endocrinology 2015
There was no change in circulating FGF23 and Klotho concentrations after PTX in hemodialysis patients given postoperative calcium supplements and/or vitamin D analogue. Serum FGF23 concentrations pre-PTX and at days 5 and 90 after PTX were inversely related to serum calcium concentrations.
Results show that Klotho is expressed in skeletal muscle and levels are reduced by smoking.
The expression levels of Klotho and autophagy are decreased in drug-resistant lung cancer cells.
Overexpression of miR (show MLXIP Proteins)-199b-5p canceled the effects of atrasentan on klotho expression and apoptosis of renal tubular cells in both in vivo and in vitro.
The influence of Klotho gene variants on Klotho gene expression levels in human vascular tissue and their association with cardiovascular disease and cardiovascular risk factors.
This study showed that serum Klotho concentration tends to be higher in MS patients when compared to control group.
Overexpression of klotho is associated with breast cancer.
Klotho mRNA and protein levels were reduced in preeclamptic placentas compared with controls. -744delA single-nucleotide polymorphism was significantly associated with preeclampsia.
These results suggest that free klotho mediates the FGF23 (show FGF23 Proteins)-induced inhibition of 1,25VD synthesis.
Data suggest that down-regulation of serum Klotho level may play role in development of atherosclerosis and endothelial dysfunction in subjects with type 1 diabetes.
In vitro studies showed interleukin-12 regulation on Klotho, while Klotho also acted as an inhibitor on interleukin-12, indicating the potential of Klotho for preserving pancreatic beta-cell function in diabetes.
Studies indicate that defect in Klotho gene expression results in a phenotype of premature aging.
beta-Klotho participates in the regulation of the peptide transporters PEPT1 and PEPT2.
FGF23 (show FGF23 Proteins) regulates osteopontin (show SPP1 Proteins) secretion indirectly by suppressing alkaline phosphatase transcription and phosphate production in osteoblastic cells, acting through FGF receptor-3 (show FGFR3 Proteins) in a Klotho-independent manner
Inhibition of mTOR (show FRAP1 Proteins) signaling ameliorates vascular calcification via Klotho upregulation.
Klotho deficiency promoted HFD-induced arterial stiffening and hypertension via downregulation of AMPKalpha (show GRK4 Proteins) activity.
level of spontaneous remyelination was increased approximately two-fold in Klotho-overexpressing mice following cuprizone-induced demyelination.
data highlight the importance of ASK1 (show MAP3K5 Proteins)/p38 MAPK (show MAPK14 Proteins) pathway in the brain and identify Klotho as a possible anti-oxidant effector
Klotho ameliorates kidney injury and fibrosis and normalizes blood pressure by targeting the renin (show REN Proteins)-angiotensin system.
significant expression of FGF23 (show FGF23 Proteins) and KL within the growth plate and adjacent tissues imply a potential local role of FGF23 (show FGF23 Proteins) in chondrocyte differentiation and tissue mineralization.
This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.
, kit ligand
, secreted form of Klotho protein