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Browse our Klotho Proteins (KL)

Full name:
Klotho Proteins (KL)
On are 13 Klotho (KL) Proteins from 7 different suppliers available. Additionally we are shipping Klotho Antibodies (92) and Klotho Kits (39) and many more products for this protein. A total of 158 Klotho products are currently listed.
alpha-kl, Kitl, KL, LOC100223456
list all proteins Gene Name GeneID UniProt
KL 9365 Q9UEF7
KL 16591 O35082
KL 83504 Q9Z2Y9

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Klotho Proteins (KL) by Origin

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Top referenced Klotho Proteins

  1. Rat (Rattus) KL Protein expressed in Escherichia coli (E. coli) - ABIN2123130 : Wu, Lv, Chen, Ma, Shao, Wang: The function of miR-199a-5p/Klotho regulating TLR4/NF-?B p65/NGAL pathways in rat mesangial cells cultured with high glucose and the mechanism. in Molecular and cellular endocrinology 2015 (PubMed)

More Proteins for Klotho Interaction Partners

Human Klotho (KL) interaction partners

  1. There was no change in circulating FGF23 and Klotho concentrations after PTX in hemodialysis patients given postoperative calcium supplements and/or vitamin D analogue. Serum FGF23 concentrations pre-PTX and at days 5 and 90 after PTX were inversely related to serum calcium concentrations.

  2. Results show that Klotho is expressed in skeletal muscle and levels are reduced by smoking.

  3. The expression levels of Klotho and autophagy are decreased in drug-resistant lung cancer cells.

  4. Overexpression of miR (show MLXIP Proteins)-199b-5p canceled the effects of atrasentan on klotho expression and apoptosis of renal tubular cells in both in vivo and in vitro.

  5. The influence of Klotho gene variants on Klotho gene expression levels in human vascular tissue and their association with cardiovascular disease and cardiovascular risk factors.

  6. This study showed that serum Klotho concentration tends to be higher in MS patients when compared to control group.

  7. Overexpression of klotho is associated with breast cancer.

  8. Klotho mRNA and protein levels were reduced in preeclamptic placentas compared with controls. -744delA single-nucleotide polymorphism was significantly associated with preeclampsia.

  9. These results suggest that free klotho mediates the FGF23 (show FGF23 Proteins)-induced inhibition of 1,25VD synthesis.

  10. Data suggest that down-regulation of serum Klotho level may play role in development of atherosclerosis and endothelial dysfunction in subjects with type 1 diabetes.

Mouse (Murine) Klotho (KL) interaction partners

  1. In vitro studies showed interleukin-12 regulation on Klotho, while Klotho also acted as an inhibitor on interleukin-12, indicating the potential of Klotho for preserving pancreatic beta-cell function in diabetes.

  2. Studies indicate that defect in Klotho gene expression results in a phenotype of premature aging.

  3. beta-Klotho participates in the regulation of the peptide transporters PEPT1 and PEPT2.

  4. Results show that Klotho is expressed in skeletal muscle and levels are reduced by smoking.

  5. FGF23 (show FGF23 Proteins) regulates osteopontin (show SPP1 Proteins) secretion indirectly by suppressing alkaline phosphatase transcription and phosphate production in osteoblastic cells, acting through FGF receptor-3 (show FGFR3 Proteins) in a Klotho-independent manner

  6. Inhibition of mTOR (show FRAP1 Proteins) signaling ameliorates vascular calcification via Klotho upregulation.

  7. Klotho deficiency promoted HFD-induced arterial stiffening and hypertension via downregulation of AMPKalpha (show GRK4 Proteins) activity.

  8. level of spontaneous remyelination was increased approximately two-fold in Klotho-overexpressing mice following cuprizone-induced demyelination.

  9. data highlight the importance of ASK1 (show MAP3K5 Proteins)/p38 MAPK (show MAPK14 Proteins) pathway in the brain and identify Klotho as a possible anti-oxidant effector

  10. Klotho ameliorates kidney injury and fibrosis and normalizes blood pressure by targeting the renin (show REN Proteins)-angiotensin system.

Pig (Porcine) Klotho (KL) interaction partners

  1. significant expression of FGF23 (show FGF23 Proteins) and KL within the growth plate and adjacent tissues imply a potential local role of FGF23 (show FGF23 Proteins) in chondrocyte differentiation and tissue mineralization.

Klotho (KL) Protein Profile

Protein Summary

This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.

Alternative names and synonyms associated with Klotho (KL)

  • klotho (KL)
  • klotho (LOC100223456)
  • klotho (kl)
  • klotho (LOC100533542)
  • klotho (Kl)
  • Klotho (Kl)
  • Klotho-like (LOC100356074)
  • alpha-kl protein
  • Kitl protein
  • KL protein
  • LOC100223456 protein

Protein level used designations for Klotho Proteins (KL)

klotho , kit ligand , secreted form of Klotho protein

467257 Pan troglodytes
100009028 Oryctolagus cuniculus
100223456 Taeniopygia guttata
100490988 Xenopus (Silurana) tropicalis
100533542 Aplysia californica
9365 Homo sapiens
16591 Mus musculus
83504 Rattus norvegicus
100685604 Canis lupus familiaris
100519728 Sus scrofa
784635 Bos taurus
100714519 Cavia porcellus
418909 Gallus gallus
101110249 Ovis aries
100356074 Oryctolagus cuniculus
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