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Human LYN Protein expressed in Escherichia coli (E. coli) - ABIN1098750
Gaul, Harrison, Geahlen, Burton, Post: Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor. in The Journal of biological chemistry 2000
Show all 2 references for ABIN1098750
Human LYN Protein expressed in Baculovirus infected Insect Cells - ABIN2003459
Yamamoto, Yamanashi, Toyoshima: Association of Src-family kinase Lyn with B-cell antigen receptor. in Immunological reviews 1993
LPS (show IRF6 Proteins) tolerance interferes with TLR4 (show TLR4 Proteins) signaling by inhibiting Lyn and c-Src (show SRC Proteins) phosphorylation and their recruitment to TLR4 (show TLR4 Proteins), while increasing the phosphatase activity and expression of PP2A (show PPP2R4 Proteins), PTPN22 (show PTPN22 Proteins), PTP1B (show PTPN1 Proteins) and MKP1 (show DUSP1 Proteins).
SYK (show SYK Proteins), LYN and PTPN6 (show PTPN6 Proteins) were markedly elevated in atherosclerotic plaques of carotid atherosclerosis patients.
Our data suggests that nuclear Lyn is a potential therapeutic target for clear cell renal cell carcinoma (show MOK Proteins) and dasatinib affects cellular functions associated with cancer progression via a Src kinase (show CSK Proteins) independent mechanism.
Authors discovered in this study that LYN was a critical gene. It was found to be the key nodule of several significant biological networks.
Inhibition of Lyn activity using dasatinib in mantle cell lymphoma overcomes bortezomib resistance.
positively regulates NF-kappaB (show NFKB1 Proteins) transactivation through the phosphorylation of the p110 subunit of PI 3 (show PI3 Proteins)-kinase
This study showed an interdependence between ROS (show ROS1 Proteins) generation and lipid rafts and Lyn relocation leading the cells to undergo the successive acrosome reaction.
SRC (show SRC Proteins), LYN and CKB (show CHKB Proteins) expression or DNA methylation (show HELLS Proteins) could be useful markers for predicting tumor progression.
Suggest an interrelated kinase module involving c-Raf (show RAF1 Proteins)/PI3K (show PIK3CA Proteins)/Lyn and perhaps Fgr (show FGR Proteins) functions in a nontraditional way during retinoic acid-induced maturation or during rescue of RA induction therapy using inhibitor co-treatment in RA-resistant leukemia cells.
Diminished Lyn levels impair Claudin-2 (show CLDN2 Proteins) expression in breast cancer cells. The Lyn-selective kinase inhibitor, Bafetinib (INNO-406), reduces Claudin-2 (show CLDN2 Proteins) expression and suppresses breast cancer liver metastasis.
Oxidized LDL-bound CD36 (show CD36 Proteins) recruits an Na/K-ATPase (show ATP1A1 Proteins)-Lyn complex in macrophages that promotes atherosclerosis.
Lyn kinase modulates inhibitory signaling to suppress endotoxin-induced lung inflammation.
A complex functional interplay between FcgammaRIIa, Lyn, and alphaIIbbeta3 in immune complex-induced platelet activation.
report that Lyn is required for bacterial infection-induced recruitment of autophagic components to pathogen-containing phagosomes
Data indicate interactions between Ets1 (show ETS1 Proteins) transcription factor and two of its important regulators: Lyn, which maintains Ets1 (show ETS1 Proteins) expression to limit the differentiation of autoreactive plasma cells (PCs), and Btk (show BTK Proteins).
results indicate that Lyn plays a positive regulatory role in RIG-I (show DDX58 Proteins)-mediated interferon (show IFNA Proteins) expression as a downstream component of IPS-1 (show ISYNA1 Proteins)
Fyn (show FYN Proteins), but not Lyn, was required for complete Pyk2 (show PTK2B Proteins) phosphorylation by thrombin (show F2 Proteins).
Data show that tyrosine protein kinase Lyn acts as a sensor of hydrogen peroxide (H2O2) levels to facilitate microglial migration toward alpha-Synuclein (alpha-syn).
Lyn is a key regulator of survival signaling in plasma cells, limiting plasma cell accumulation and autoimmune disease susceptibility.
Lyn is a key regulator of the mucosal immune system, governing pathophysiology in multiple models of intestinal disease.
This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
tyrosine-protein kinase Lyn
, v-yes-1 Yamaguchi sarcoma viral related oncogene protein-like protein
, lyn protein tyrosine kinase
, v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
, Tyrosine-protein kinase Lyn
, lck/Yes-related novel protein tyrosine kinase
, Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
, lyn protein non-receptor kinase
, V-yes-1 Yamaguchi sarcoma viral related oncogene homolog