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SHP-1 (show PTPN6 Proteins) tyrosine 536 phosphorylation by Lyn activates the phosphatase promoting inhibitory signaling through the immunoreceptor.
A novel pancancer mechanism of Lyn-dependent control of epithelial-mesenchymal transition and role of this kinase in tumor progression.
Authors demonstrate that LYN kinase is essential for CLL progression. Lyn deficiency results in a significantly reduced CLL burden in vivo.
Our studies indicate not only a concept of mucus hypersecretion in asthma that involves Lyn kinase but also an important therapeutic candidate for asthma.
LPS (show IRF6 Proteins) tolerance interferes with TLR4 (show TLR4 Proteins) signaling by inhibiting Lyn and c-Src (show SRC Proteins) phosphorylation and their recruitment to TLR4 (show TLR4 Proteins), while increasing the phosphatase activity and expression of PP2A (show PPP2R4 Proteins), PTPN22 (show PTPN22 Proteins), PTP1B (show PTPN1 Proteins) and MKP1 (show DUSP1 Proteins).
SYK (show SYK Proteins), LYN and PTPN6 (show PTPN6 Proteins) were markedly elevated in atherosclerotic plaques of carotid atherosclerosis patients.
Our data suggests that nuclear Lyn is a potential therapeutic target for clear cell renal cell carcinoma (show MOK Proteins) and dasatinib affects cellular functions associated with cancer progression via a Src kinase (show CSK Proteins) independent mechanism.
Authors discovered in this study that LYN was a critical gene. It was found to be the key nodule of several significant biological networks.
Inhibition of Lyn activity using dasatinib in mantle cell lymphoma overcomes bortezomib resistance.
positively regulates NF-kappaB (show NFKB1 Proteins) transactivation through the phosphorylation of the p110 subunit of PI 3 (show PI3 Proteins)-kinase
these results reveal a role for Lyn as a specific suppressor of the TLR-MyD88 (show MYD88 Proteins)-IRF5 (show IRF5 Proteins) pathway and illustrate the importance of fine-tuning IRF5 (show IRF5 Proteins) activity for the maintenance of immune homeostasis
These findings reveal that the function and regulation of Lyn during B1 cell B cell receptor signaling is distinct from other B cell subsets.
A mutation in LYN, an inhibitory protein tyrosine kinase (show YES1 Proteins) that is implicated in systemic autoimmunity, combines with an Aire (show AIRE Proteins) mutation to provoke organ-specific autoimmunity.
the Hck, Fgr and Lyn kinases are also necessary for amastigote uptake by macrophages. Src-mediated Arg activation is required for efficient uptake.
the Lyn mutation in NOD neutrophils is likely responsible for dysregulation of neutrophil adhesion and directed migration.
Oxidized LDL-bound CD36 (show CD36 Proteins) recruits an Na/K-ATPase (show ATP1A1 Proteins)-Lyn complex in macrophages that promotes atherosclerosis.
Lyn kinase modulates inhibitory signaling to suppress endotoxin-induced lung inflammation.
A complex functional interplay between FcgammaRIIa, Lyn, and alphaIIbbeta3 in immune complex-induced platelet activation.
results explain how early H2O2 signal regulates neutrophil recruitment at all phases, directly via Lyn oxidation or indirectly by modulating cxcl8 (show IL8 Proteins) gene expression
identify the Src (show SRC Proteins) family kinase (SFK) Lyn as a redox sensor that mediates initial neutrophil recruitment to wounds in zebrafish larvae
This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
lck/Yes-related novel protein tyrosine kinase
, tyrosine-protein kinase Lyn
, Tyrosine-protein kinase Lyn
, lyn protein tyrosine kinase
, lyn protein non-receptor kinase
, v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
, v-yes-1 Yamaguchi sarcoma viral related oncogene protein-like protein
, V-yes-1 Yamaguchi sarcoma viral related oncogene homolog
, Yamaguchi sarcoma viral (v-yes-1) oncogene homolog