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these results establish MOV10, an evolutionary conserved protein involved in RNA silencing, as an antiviral gene against RNA viruses that uses an retinoic acid-inducible gene I (show DDX58 Proteins)-like receptor-independent pathway to enhance IFN response
IRAV is an RNA binding protein (show PTBP1 Proteins) and localizes to cytoplasmic processing bodies (P bodies) in uninfected cells, where it interacts with the MOV10 RISC complex RNA helicase, suggesting a role for IRAV in the processing of viral RNA.
MOV10 is a highly conserved cellular protein belonging to SF1 helicase family that plays critical roles in EV71 infection
MOV10 acts as an anti-influenza virus factor through specifically inhibiting the nuclear transportation of nucleoprotein and subsequently inhibiting the function of the viral ribonucleoprotein complex
The DEAG-box of huamn MOV10 was required for the enhancement of Rev/RRE-dependent nuclear export.
The endogenous Mov10 could promote hepatitis B virus replication in vitro.
A dual function for MOV10 in regulating translation: it facilitates microRNA-mediated translation of some RNAs, but it also increases expression of other RNAs by preventing AGO2 (show EIF2C2 Proteins) function.
Results show that MOV10 predominantly binds to 3' UTRs upstream of regions predicted to form local secondary structures and provide evidence that MOV10 helicase mutants are impaired in their ability to translocate 5' to 3' on their mRNA targets.
Association of the SNP rs2932538 in MOV10 and SNP rs4373814 in CACNB2 with an increased risk of hypertension in a Chinese Han population.
MOV10 contributes to the cellular control of long interspersed element 1 replication.
Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA- mediated cleavage of complementary mRNAs by RISC (By similarity).
Mov10, Moloney leukemia virus 10, homolog (mouse)
, moloney leukemia virus 10 protein
, putative helicase MOV-10
, Mov10, Moloney leukemia virus 10
, capping protein (actin filament) muscle Z-line, alpha 1
, functional spliceosome-associated protein 113