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Our study predicted that UBC and RPA had potential as target genes for the diagnosis and treatment of osteosarcoma
Data show that at least three heat shock elements with different configurations, exist in the UBC (show RPS27A Proteins) promoter. All of them are bound by transcription factors belonging to the heat shock factor family clarifying the mechanisms regulating UBC (show RPS27A Proteins) expression.
Data show that discoidin domain receptor 2 (DDR2) is linked to a polyubiquitin (Ub) chain predominantly through lysine K27 conjugation and slightly through K33.
USP4 requires its N-terminal DUSP-Ubl domain to achieve full catalytic turnover by promoting ubiquitin exchange.
Data suggest that ubiquitin-conjugating enzyme E2 variant 2 (Ube2V2 (show UBE2V2 Proteins)) and ring finger protein 4 (RNF4 (show RNF4 Proteins)) together induce an active conformation of the ubiquitin-conjugating enzyme (show Ube2t Proteins) Ubc13 (show UBE2N Proteins)-ubiquitin (Ubc13 (show UBE2N Proteins)~Ub) thioester.
noncovalent ubiquitin:ubiquitin interactions are nearly identical to those reported for Lys11-linked ubiquitin and seem to play a significant role in stabilizing the crystal structure without the isopeptide bond.
Studies indicate that ubiquitin proteasome system (UPS) controls all aspects of cholesterol metabolism including its synthesis, uptake, and efflux.
Studies suggest that quantitative proteomic approaches would set a standard for elucidating biochemical mechanisms of Ubiquitin (UB)-driven signaling systems.
In testicular germ cell tumors, the ubiquitin expression is decreased indicating disturbances of ubiquitin-proteolysis system components at the initial stages of testicular tissue carcinogenesis.
Data indicate that TRAF interacting protein (show TANK Proteins) TRIP negatively regulates the TNFR (show TNFRSF1A Proteins)-associated factor 2 (TRAF2 (show TRAF2 Proteins)) ubiquitin-dependent pathway by modulating the TRAF2 (show TRAF2 Proteins)-sphingosine 1-phosphate (S1P (show MBTPS1 Proteins)) interaction.
Ubc (show UBA52 Proteins)-/- mouse embryonic fibroblasts (MEFs) exhibited reduced viability under As(III) exposure, although the Nrf2 (show NFE2L2 Proteins)-Keap1 (show KEAP1 Proteins) pathway was activated as a cytoprotective response.
phosphorylation of Parkin (show PARK2 Proteins) at Ser (show SIGLEC1 Proteins)-65 following dissipation of DeltaPsim triggers ubiquitin-ester transfer by the RING2 (show HSD17B8 Proteins) domain of Parkin (show PARK2 Proteins) to Cys (show DNAJC5 Proteins)-431.
Defective proliferation of fetal liver cells contributes to severe reduction of fetal liver size and potentially mid-gestation lethality of Ubc (show UBA52 Proteins)-deficient embryos
Data indicate that Ubc (show UBA52 Proteins) and Ywhaz (show YWHAZ Proteins) were best correlated for B cells and lymphocytes, whereas Ubc (show UBA52 Proteins) and Gapdh (show GAPDH Proteins) were the best combination for non-B cells, and Actb (show ACTB Proteins) and Hprt1 (show HPRT1 Proteins) were the least stably expressed genes for B cells and non-B cell.
the lethality of Ubc (show UBA52 Proteins)(-/-) embryos is not the result of intrinsic HSC (show FUT1 Proteins) failure
reduction of Ubc (show UBA52 Proteins) expression in R6/2; Ubc (show UBA52 Proteins)+/- mice largely prevented this increase in uH2A levels
regulation of ubiquitin C expression contributes to attenuation of skin carcinogenesis
The mouse polyubiquitin (show UBB Proteins) gene UbC (show UBA52 Proteins) is essential for fetal liver development, cell-cycle progression and stress tolerance.
This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis, and regulation of other cell signaling pathways.
, polyubiquitin C
, ubiquitin copy 4