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Model of ASB9 in complex with its substrate, creatine kinase, reveals a mechanism for dynamic ubiquitin transfer.
The lysine48-lysine63 branched ubiquitin chain regulates NF-kappaB (show NFKB1 Proteins) signaling.
Noncovalent ubiquitin interactions regulate the catalytic activity of ubiquitin writers. (Review)
The authors now report the crystal structure of a human Parkin-phosphoubiquitin complex, which shows that phosphoubiquitin binding induces movement in the 'in-between RING' (IBR) domain to reveal a cryptic ubiquitin-binding site.
Studies indicate a role for the ubiquitin-proteasome system (UPS) as a key regulator of ciliogenesis.
Chicago Sky (show TYRO3 Proteins) Blue 6B (CSB6B) binds directly to the beta-groove of ubiquitin and could inhibit the binding of ubiquitin to chemokine (C-X-C motif) receptor 4 (CXCR4 (show CXCR4 Proteins)), a cell surface ubiquitin receptor.
Studies suggest that ubiquitin signals for the proteasome involved more that Lys48 (K48).
Data show that the stereospecific complex of ubiquitin and the ubiquitin-associated domain (UBA) is minimally perturbed by the crowding agent Ficoll.
Studies indicate complex ubiquitin architectures function as important signals including post-translational modification (PTM) of ubiquitin itself, such as acetylated ubiquitin and phospho-ubiquitin..
Our study predicted that UBC and RPA had potential as target genes for the diagnosis and treatment of osteosarcoma
Ubc (show UBA52 Proteins)-/- mouse embryonic fibroblasts (MEFs) exhibited reduced viability under As(III) exposure, although the Nrf2 (show NFE2L2 Proteins)-Keap1 (show KEAP1 Proteins) pathway was activated as a cytoprotective response.
phosphorylation of Parkin (show PARK2 Proteins) at Ser (show SIGLEC1 Proteins)-65 following dissipation of DeltaPsim triggers ubiquitin-ester transfer by the RING2 (show HSD17B8 Proteins) domain of Parkin (show PARK2 Proteins) to Cys (show DNAJC5 Proteins)-431.
Defective proliferation of fetal liver cells contributes to severe reduction of fetal liver size and potentially mid-gestation lethality of Ubc (show UBA52 Proteins)-deficient embryos
Data indicate that Ubc (show UBA52 Proteins) and Ywhaz (show YWHAZ Proteins) were best correlated for B cells and lymphocytes, whereas Ubc (show UBA52 Proteins) and Gapdh (show GAPDH Proteins) were the best combination for non-B cells, and Actb (show ACTB Proteins) and Hprt1 (show HPRT1 Proteins) were the least stably expressed genes for B cells and non-B cell.
the lethality of Ubc (show UBA52 Proteins)(-/-) embryos is not the result of intrinsic HSC (show FUT1 Proteins) failure
reduction of Ubc (show UBA52 Proteins) expression in R6/2; Ubc (show UBA52 Proteins)+/- mice largely prevented this increase in uH2A levels
regulation of ubiquitin C expression contributes to attenuation of skin carcinogenesis
The mouse polyubiquitin (show UBB Proteins) gene UbC (show UBA52 Proteins) is essential for fetal liver development, cell-cycle progression and stress tolerance.
This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis, and regulation of other cell signaling pathways.
, polyubiquitin C
, ubiquitin copy 4