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Manipulating steroidogenic factor-1 (SF-1 (show NR5A1 ELISA Kits)) and nucleotide exchange factor VAV-2 (VAV2) abundance in cultured adrenocortical carcinoma (ACC (show ACACA ELISA Kits)) cells indicate that VAV2 was a critical factor for SF-1 (show NR5A1 ELISA Kits)-induced cytoskeletal remodeling and invasion in culture and in vivo (chicken chorioallantoic membrane) models.
Data indicate that phosphorylated cortactin recruits Vav2 to activate Rac3 and promote invadopodial maturation in invasive breast cancer cells.
autocrine VEGF (show VEGFA ELISA Kits) and IL-8 (show IL8 ELISA Kits) promoted endothelial cell migration via the Src (show SRC ELISA Kits)/Vav2/Rac1/PAK1 (show PAK1 ELISA Kits) signaling pathway.
We concluded that Vav2 might promote invasion and metastasis of gastric cancer by regulating some invasion and metastasis-related genes.
work suggested that EphB3 (show EPHB3 ELISA Kits) acted as a tumor promoter in Papillary Thyroid Cancer by increasing the in vitro migration as well as the in vivo metastasis of Papillary Thyroid Cancer cells through regulating the activities of Vav2 and Rho GTPases in a kinase-dependent manner.
The crystal structure of the complex between a phosphorylated PPxY motif of TXNIP (show TXNIP ELISA Kits) and the SH2 domain of Vav2 reveals a conserved recognition mechanism.
Our data provide the first evidence to implicate VAV2 in glucose-induced Rac1 activation, actin remodelling and glucose-stimulated insulin (show INS ELISA Kits) secretion in pancreatic beta cells.
VAV2 is required for Met signaling in the perinuclear endosome.
Authors propose a model whereby vimentin (show VIM ELISA Kits) promotes FAK (show PTK2 ELISA Kits) stabilization through VAV2-mediated Rac1 activation. This model may explain why vimentin (show VIM ELISA Kits) expressing metastatic lung cancer cells are more motile and invasive.
Data suggest a coordination between paxillin (show PXN ELISA Kits) kinase linker (PKL (show PKLR ELISA Kits))/Vav2 signaling and PKL (show PKLR ELISA Kits)/beta-PIX (show ARHGEF7 ELISA Kits) signaling during cell migration.
This inhibitory action of Vav2 shRNA on Hcys-induced podocyte injury was associated with reduction of Rac1 activity and ROS (show ROS1 ELISA Kits) production. These results suggest that elevated Hcys levels activate Vav2 and thereby increase NOX activity leading to ROS (show ROS1 ELISA Kits) production, which triggers NLRP3 (show NLRP3 ELISA Kits) inflammasome activation, podocyte dysfunction and glomerular injury.
Results show that Vav2 and Rac1 are commonly involved in blood pressure regulation.
Data demonstrate that the co-expression of the exchange factors Vav2 and Vav3 (show VAV3 ELISA Kits) is critical for the development of this tumor type.
Vav2 and Vav3 (show VAV3 ELISA Kits) are required for normal peripheral nerve degeneration/regeneration, revascularization and functional recovery.
The results indicate that ADIP (show SSX2IP ELISA Kits) plays an essential role in PDGF (show PDGFA ELISA Kits)-induced cell movement by interacting with afadin (show MLLT4 ELISA Kits) and Vav2 and regulating the activation of Rac (show AKT1 ELISA Kits).
CD36 (show CD36 ELISA Kits) contributes to activation of Vav-1 (show VAV1 ELISA Kits), -2, and -3 in aortae from hyperlipidemic mice
Cbl (show CBL ELISA Kits) ubiquitin ligase (show RNF123 ELISA Kits) plays a critical role in the maintenance of AJs and suppression of cell migration through down-regulation of EGFR (show EGFR ELISA Kits)-Vav2 signaling.
Data show that Vav2/Vav3 (show VAV3 ELISA Kits)-deficient mice show early onset of iridocorneal angle changes and elevated intraocular pressure, with subsequent selective loss of retinal ganglion cells and optic nerve head cupping, which are the hallmarks of glaucoma.
Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells.
does not contribute to platelet aggregation by CRP (show CRP ELISA Kits) and thrombin (show F2 ELISA Kits), and is not required for regulation of phospholipase C (show PLC ELISA Kits).
VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
guanine nucleotide exchange factor VAV2
, vav 2 oncogene
, Vav2 oncogene