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Human AGRP ELISA Kit - ABIN2065211
Ahmed, Latheef, Bartley, Irish, Halliday, Kiernan, Hodges, Piguet: Eating behavior in frontotemporal dementia: Peripheral hormones vs hypothalamic pathology. in Neurology 2015
Human AGRP ELISA Kit for Sandwich ELISA - ABIN625264
Wysoki?ski, Ka?mierski, K?oszewska: Serum levels of AgRP protein in patients with schizophrenia on clozapine monotherapy. in Metabolic brain disease 2015
It was concluded that a small population of neuroendocrine cells in the adrenal medulla, and the arcuate nucleus of the hypothalamus, express AgRP and neuropeptide Y (show NPY ELISA Kits) and are functionally involved in the systemic response to fasting.
These findings indicate that the relevance of AgRP to POMC (show POMC ELISA Kits) neuron GABA connectivity depends on the state of AgRP neuron activity and suggest that different types of transmitter release should be considered when circuit mapping.
CRFR1 (show CRHR1 ELISA Kits), in a subset of AgRP neurons, plays a regulatory role that enables appropriate sympathetic nervous system activation and consequently protects the organism from hypothermia and hypoglycemia.
Diet composition, not calorie intake, rapidly alters intrinsic excitability of hypothalamic AgRP/NPY (show NPY ELISA Kits) neurons in mice.
Data show that agouti-related protein (AgRP)-glucocorticoid receptor (show NR3C1 ELISA Kits) knockout (GR-/-) mice are resistant to diet-induced obesity.
Data show that chronic caloric restriction (CR) alters hypothalamic agouti-related protein (Agrp) and neuropeptide Y (Npy (show NPY ELISA Kits)) gene expression similarly in Ghrelin (show GHRL ELISA Kits)+/+, Ghrelin (show GHRL ELISA Kits)-/-, ghrelin receptor Ghsr (show GHSR ELISA Kits)+/+, and Ghsr (show GHSR ELISA Kits)-/- mice.
Suppression of sympathetic tone in AgRP-Sirt1 (show SIRT1 ELISA Kits)/(--) mice reversed osteopenia in transgenic animals.
Data (including data from studies in transgenic/knockout mice) suggest that expression in adult brain neurons (especially in parabrachial nucleus) of both Dmbx1 (show DMBX1 ELISA Kits) (deleted in malignant brain tumors 1 (show DMBT1 ELISA Kits)) and AgRP is important in appetite regulation.
mTORC1 in Agrp neurons controls circadian expression of orexigenic neuropeptides but is dispensable for the regulation of feeding behavior and energy metabolism
Absence of Mc3rs (but not Ghsrs) was associated with lower AgRP/Npy (show NPY ELISA Kits) expression, suggesting attenuated responses to signals of negative energy balance.
data provide compelling evidence that AgRP is a heparan sulfate-binding protein and localizes critical regions in the AgRP structure required for this interaction.
The aim of this survey is to evaluate the association of genetic variants of melanocortin-4-receptor (MC4R (show MC4R ELISA Kits)), pro-opiomelanocortin (POMC (show POMC ELISA Kits)), apolipoprotein E (APOE (show APOE ELISA Kits)) and agouti-related protein (AGRP) with obesity in the North Indian population.
CSF (show CSF2 ELISA Kits) AgRP was not different in lean vs. overweight/obese subjects; however, plasma AgRP was higher in lean subjects.
human agouti-related protein has a role in enhancing expression and stability of human melanocortin-4 receptor (show MC4R ELISA Kits)
Variations in genes AGRP, CPE (show CPE ELISA Kits), GHRL (show GHRL ELISA Kits), GLP1R (show GLP1R ELISA Kits), HTR2A, NPY1R (show NPY1R ELISA Kits), NPY5R (show NPY5R ELISA Kits), SOCS3 (show SOCS3 ELISA Kits) and STAT3 (show STAT3 ELISA Kits) showed modest associations with BMI in European Americans.
Elevations in AgRP also favor the diagnosis of ectopic ACTH (show POMC ELISA Kits) syndrome, suggesting AgRP should be further evaluated as a potential neuroendocrine tumor marker.
AGRP SNP (rs1338993) was not associated with antipsychotic-induced weight gain in schizophrenia patients.
Data suggest that prolonged steady-state exercise/physical activity at moderate intensity elicits substantial increases in blood lactate and cortisol concentrations without a significant change in AgRP; study was pilot project involving men.
Despite peripheral hyperleptinemia, positive energy balance is achieved during pregnancy by a relative decrease in central leptin (show LEP ELISA Kits) concentrations and resistance to leptin's effects on target neuropeptides that regulate energy balance.
AgRP and NPY (show NPY ELISA Kits) are correlated with body weight changes, rather than the presence of type 2 diabetes, whereas changes in alphaMSH (show POMC ELISA Kits) immunoreactivity are related to the presence of type 2 diabetes, indicating separate hypothalamic mechanisms.
(Nle4, d-Phe7)-alphaMSH (show POMC ELISA Kits) (NDP (show NDP ELISA Kits)-alphaMSH (show POMC ELISA Kits)) stimulated the production of cortisol and these effects were abolished by agouti related protein or SHU9119, a synthetic antagonist of melanocortin 3 and melanocortin 4 receptor (show MC4R ELISA Kits)
Agrp inhibited, in a dose-dependent manner, the 10(-9) M NDP (show NDP ELISA Kits)-alphaMSH (show POMC ELISA Kits)-induced cortisol production through its antagonistic properties towards MSH (show POMC ELISA Kits) at the level of MC4-R (show MC4R ELISA Kits)
This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity.
, orexigenic neuropeptide
, agouti related protein homolog (mouse)
, agouti related protein