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anti-Human CNR1 Antibodies:
anti-Rat (Rattus) CNR1 Antibodies:
anti-Mouse (Murine) CNR1 Antibodies:
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Human Polyclonal CNR1 Primary Antibody for WB - ABIN1881140
Van Laere, Casteels, Dhollander, Goffin, Grachev, Bormans, Vandenberghe: Widespread decrease of type 1 cannabinoid receptor availability in Huntington disease in vivo. in Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2010
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Human Polyclonal CNR1 Primary Antibody for ELISA, WB - ABIN250833
Porcella, Maxia, Gessa, Pani: The human eye expresses high levels of CB1 cannabinoid receptor mRNA and protein. in The European journal of neuroscience 2000
Show all 3 Pubmed References
Human Polyclonal CNR1 Primary Antibody for ICC, IHC (fro) - ABIN152711
Mulhern, Madson, Danford, Ikesugi, Kador, Shinohara: The unfolded protein response in lens epithelial cells from galactosemic rat lenses. in Investigative ophthalmology & visual science 2006
Anandamide, through CB1 and TRPV1 (show TRPV1 Antibodies) activation, is involved in sperm release from the oviductal reservoir.
genetic or chemical inhibition of cannabinoid receptor (Cnr (show PCDHA1 Antibodies)) activity disrupts liver development and metabolic function in zebrafish.
CB1 function is required in the early embryo for axonal growth and fasciculation.
that a genetically modulated balancing of signaling within the CB1-COX-2 (show COX2 Antibodies) pathway may reflect on more or less efficient patterns of prefrontal activity during working memory
In cotransfected HEK (show EPHA3 Antibodies)-293 cells, SSTR5 (show SSTR5 Antibodies) and CB1R existed in a constitutive heteromeric complex under basal condition, which was disrupted upon agonist treatments. Furthermore, concurrent receptor activation led to preferential formation of SSTR5 (show SSTR5 Antibodies) homodimer and dissociation of CB1R homodimer.
CB1R availability was inversely associated with BMI in homeostatic brain regions such as the hypothalamus and brainstem areas in both patients with food intake disorders(FID) and healthy subjects. However, in FID patients, CB1R availability was also negatively correlated with BMI throughout the mesolimbic reward system.
hepatic expression of CB1 and CB2 (show CNR2 Antibodies) plays an important role during the progression of fibrosis induced by chronic hepatitis B
propose here a possible unifying theory of CB1 receptor functions.
Patients with schizophrenia showed increased CB1A expression in cells of the innate immune system and simpler correlation network between cytokines and CBRs expression when compared with controls.
our systematic review on potential associations of CNR1 polymorphisms with schizophrenia and its subphenotypes revealed conflicting data, with results tending towards a negative association.
Our study disclosed an increased risk of CVS among individuals with AG and GG genotypes of CNR1 rs806380 ( P <0.01), whereas the CC genotype of CNR1 rs806368 was associated with a decreased risk of CVS ( P <0.05). In addition CT and CC genotypes of CNR1 rs806368 were associated with a family history of migraines.
U46619 and ANG II (show AGT Antibodies) may stimulate rapid endothelial release of endocannabinoids (mainly 2-arachidonoylglycerol), leading to CB1 receptor-dependent and/or CB1 receptor-independent vasorelaxation, which in the negative feedback mechanism reduces later agonist-induced vasoconstriction.
Data suggest that signaling via endocannabinoids and CNR1/CNR2 plays central role in food intake; the endocannabinoid system regulates bidirectional communication (in the context of energy intake and storage) between the brain and peripheral tissues (adipose tissue, liver, gastrointestinal tract, endocrine pancreas, and skeletal muscle). [REVIEW]
mGluR5 (show GRM5 Antibodies) and CB1 act in concert to activate neuroprotective cell signaling pathways and promote neuronal survival.
Salicylate-induced tinnitus may be associated with increased mRNA expression of the DR1A gene - but with decreased mRNA expression of the CR1 (show TDGF1 Antibodies) gene - in the cochlea and in many tinnitus-related brain areas.
analysis of the composition and differences of CB1 protein complexes in glutamatergic neurons and in GABAergic interneurons in hippocampal mouse tissue by proteomics
Identification of mouse CB1 receptor splice variants may help to explain differences found between human and mouse endocannabinoid systems and improve the understanding of CB1 receptor signaling and trafficking in different species
our results reveal that ERRgamma (show ESRRG Antibodies), induced via activation of the hepatic CB1 receptor, is a regulator of hepatic FGF21 (show FGF21 Antibodies) gene expression and secretion.
Morphine-induced conditioned place preference (CPP) elevated Cannabinoid CB1 receptor (CB1R) expression both in the nucleus accumbens and hippocampus. AM251 attenuated morphine-induced CPP and CB1R expression in the NAc (show NLRP1 Antibodies) and Hippocampus. CB1R mediated downstream ERK (show EPHB2 Antibodies)-CREB (show CREB1 Antibodies)-BDNF (show BDNF Antibodies) signaling is implicated in morphine reward.
In the present study, the functional coupling of Gi/o protein-coupled receptors to GalR1 (show GALR1 Antibodies), and the CB1 receptor subtype for endocannabinoids were analyzed in the 3xTg-AD mice model of Alzheimer's disease in the prodromal and advanced stages. In addition, the activity mediated by Gi/o protein-coupled M2/4 (show GSDMD Antibodies) muscarinic receptor (show CHRM5 Antibodies) subtypes was also analyzed in brain areas involved in anxiety and cognition.
A bidirectional link was found between the CB1 receptor and microRNA let-7d involved in the regulation of cannabinoid signaling.
Study investigated the impact of the CB1 receptor ligands on the symptoms typical for schizophrenia. Antipsychotic-like effects induced by CB1 receptor antagonist, obtained in our research, confirm the potential effect of CB1 receptor blockade and could have important therapeutic implications on clinical settings, in the future.
CB1 activation enhances protein synthesis via the mTOR (show FRAP1 Antibodies) pathway, resulting in long-term depression of inhibitory transmission in GABA-ergic presynaptic interneuron axons.
The endocannabinoid system in renal cells: regulation of sodium transport by CB1 receptors through distinct cell signaling pathways
A novel mechanism has been identified underlying a CB1R-mediated increase in retinal ganglion cell intrinsic excitability acting through AMPK (show PRKAA2 Antibodies)-dependent inhibition of NKCC1 (show SLC12A2 Antibodies) activity.
CB1 functionality increased with development at both central and peripheral level.
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene.
cannabinoid receptor 1 (brain)
, cannabinoid receptor (brain)
, cannabinoid receptor 1
, cannabinoid receptor 1-like
, central cannabinoid receptor
, brain-type cannabinoid receptor
, striatal cannabinoid receptor type 1 protein
, cannabinoid 1 receptor
, CB1 cannabinoid receptor
, cannabinoid receptor CB-1
, cannabinoid receptor 1/CB1