Browse our Glutaminase Proteins (GLS)

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Glutaminase Proteins (GLS)
On www.antibodies-online.com are 6 Glutaminase (GLS) Proteins from 4 different suppliers available. Additionally we are shipping Glutaminase Antibodies (82) and Glutaminase Kits (21) and many more products for this protein. A total of 111 Glutaminase products are currently listed.
Synonyms:
6330442B14, A330074B06Rik, AAD20, AI195532, AI314027, B230365M23Rik, BA3155, CG8772, CG8872, Dmel\\CG42708, Dmel_CG8772, GA, GAC, GAM, GLS, GLS1, Glut, KGA, Lga, PAG, RATGLUT, si:dz87i4.2, wu:fa97e05
list all proteins Gene Name GeneID UniProt
GLS 14660 D3Z7P3
GLS 2744 O94925
GLS 24398 P13264

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Glutaminase Proteins (GLS) by Origin

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More Proteins for Glutaminase Interaction Partners

Mouse (Murine) Glutaminase (GLS) interaction partners

  1. Gls2 (show GLS2 Proteins) expression is regulated by the dietary protein/carbohydrate ratio. This effect was not observed in Ppara (show PPARA Proteins)-null mice.

  2. studies show that the formation of large GAC oligomers is not a pre-requisite for full enzymatic activity. They also offer a mechanism by which the binding of activators like inorganic phosphate enables the activation loop to communicate with the active site to ensure maximal rates of catalysis, and promotes the opening of the lid to achieve optimal product release.

  3. Conformational changes in the activation loop of mitochondrial glutaminase C: A direct fluorescence readout that distinguishes the binding of allosteric inhibitors from activators.

  4. findings suggest that glutaminase Heterozygote mice have a pro-cognitive profile in the trace fear conditioning paradigm, and this phenotype involves activation of both hippocampus and Anterior Cingulate Cortex.

  5. studies demonstrate that GLS is required for tumorigenesis and support small molecule and genetic inhibition of GLS as potential approaches for targeting the tumor cell-autonomous dependence on GLS for cancer therapy.

  6. The Phosphate-Activated Glutaminase (show GLS2 Proteins)(PAG (show PRDX1 Proteins)) is mainly active in mouse kidney, brain and liver, and shows different kinetics depending on which type of PAG (show PRDX1 Proteins) is expressed.

  7. The network identified in glutaminase deficient fetal mouse brain involves (a) cellular assembly and organization and (b) cell signaling and cell cycle, suggesting that Gls is crucial for neuronal maturation.

  8. kidney-type glutaminase (KGA) as a novel partner of Bmcc1s

  9. The up-regulation of neuronal glutaminase was demonstrated in situ in a murine model of HIV-1 encephalitis.

  10. identified a novel distant regulatory element located approximately 120kb downstream of the gls promoter, and examined its regulatory relevance to gls gene expression in C2C12 cells

Fruit Fly (Drosophila melanogaster) Glutaminase (GLS) interaction partners

  1. The memory deficits observed in nemy are because of reduced function of CytB561 (show CYB561 Proteins) in specific brain regions that are involved in learning and memory.

Human Glutaminase (GLS) interaction partners

  1. the crystal structure of full-length KGA and present a small-angle X-ray scattering model for full-length GLS2 (show GLS2 Proteins). These structures explain these proteins' compromised ability to assemble into catalytically active supra-tetrameric filaments, as previously shown for GAC.

  2. GLS1 inhibition using BPTES reduced metabolic intermediates including thymidine and carbamoyl phosphate. Reduction of thymidine and carbamoyl-phosphate synthesis by BPTES treatment exacerbated pyrimidine supply by combination with 5-FU, which induced cell death synergistically in NSCLC

  3. studies show that the formation of large GAC oligomers is not a pre-requisite for full enzymatic activity. They also offer a mechanism by which the binding of activators like inorganic phosphate enables the activation loop to communicate with the active site to ensure maximal rates of catalysis, and promotes the opening of the lid to achieve optimal product release.

  4. Glutaminase expression in tumor cells was significantly associated with a low level of tumor-infiltrating lymphocytesand poor disease-free survival in triple-negative breast cancers presenting with lymph node metastasis and high levels of tumor-infiltrating lymphocytes.

  5. Study reports that GLS1 is a direct target of miR (show MLXIP Proteins)-23a in retinal pigment epithelium cells (RPE (show RPE Proteins)) providing evidence for a role in maintaining RPE (show RPE Proteins) cell function.

  6. The relative expression of microRNA-153 and glutaminase in glioblastoma versus matched non-tumor tissues showed a reverse correlation, further indicating that microRNA-153 may negatively regulate glutaminase in vivo.

  7. High GLS1 expression is associated with epithelial-mesenchymal transition in cancer.

  8. Data suggest that glutaminase C (GAC) inhibition maybe a potential treatment strategy for acquired erlotinib-resistant non-small cell lung cancer (NSCLC).

  9. Findings indicate a role for transcription factor c-Jun (show JUN Proteins) as a driver of cancer cell metabolic reprogramming, and suggest that cancers overexpressing JUN (show JUN Proteins) may be especially sensitive to glutaminase (GLS)-targeted therapies.

  10. GLS1 was identified as a potential downstream target of the miR (show MLXIP Proteins)-192/-204-HOTTIP axis in hepatocellular carcinoma.

Glutaminase (GLS) Protein Profile

Protein Summary

This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants.

Alternative names and synonyms associated with Glutaminase (GLS)

  • glutaminase (GLS)
  • glutaminase (Gls)
  • glutaminase (gls)
  • glutaminase b (glsb)
  • CG42708 gene product from transcript CG42708-RA (CG42708)
  • hypothetical protein (glutaminase)
  • glutaminase (glsA-2)
  • glutaminase (Arnit_3113)
  • glutaminase (Celal_2913)
  • Glutaminase (Odosp_0379)
  • Glutaminase (Odosp_1505)
  • Glutaminase (Celly_0289)
  • glutaminase (Weevi_2101)
  • glutaminase (Mesop_4683)
  • glutaminase 2 (liver, mitochondrial) (Gls2)
  • 6330442B14 protein
  • A330074B06Rik protein
  • AAD20 protein
  • AI195532 protein
  • AI314027 protein
  • B230365M23Rik protein
  • BA3155 protein
  • CG8772 protein
  • CG8872 protein
  • Dmel\\CG42708 protein
  • Dmel_CG8772 protein
  • GA protein
  • GAC protein
  • GAM protein
  • GLS protein
  • GLS1 protein
  • Glut protein
  • KGA protein
  • Lga protein
  • PAG protein
  • RATGLUT protein
  • si:dz87i4.2 protein
  • wu:fa97e05 protein

Protein level used designations for Glutaminase Proteins (GLS)

glutaminase kidney isoform, mitochondrial , phosphate-activated glutaminase , glutaminase C , glutaminase , CG42708-PA , CG42708-PB , CG42708-PC , CG42708-PD , CG42708-PE , CG42708-PF , CG42708-PH , CG42708-PI , hypothetical protein , Glutaminase , K-glutaminase , L-glutamine amidohydrolase , glutaminase, phosphate-activated , L-glutaminase , glutaminase liver isoform, mitochondrial , liver mitochondrial glutaminase

GENE ID SPECIES
525335 Bos taurus
488448 Canis lupus familiaris
399525 Sus scrofa
14660 Mus musculus
100069617 Equus caballus
470606 Pan troglodytes
5620641 Bacillus pumilus SAFR-032
564746 Danio rerio
424043 Gallus gallus
36396 Drosophila melanogaster
172547 Caenorhabditis elegans
174282 Caenorhabditis elegans
1086611 Bacillus anthracis str. Ames
2815154 Bacillus anthracis str. 'Ames Ancestor'
9173316 Arcobacter nitrofigilis DSM 7299
10145336 Cellulophaga algicola DSM 14237
10252085 Odoribacter splanchnicus DSM 220712
10253226 Odoribacter splanchnicus DSM 220712
10262273 Cellulophaga lytica DSM 7489
10283366 Weeksella virosa DSM 16922
10828538 Mesorhizobium opportunistum WSM2075
2744 Homo sapiens
24398 Rattus norvegicus
216456 Mus musculus
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