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These data confirmed expression of orexin and its two receptors in the bovine adrenal gland.
Data show that fish lacking the hypocretin receptor demonstrate short and fragmented sleep in the dark, in striking contrast to the excessive sleepiness and cataplexy of narcolepsy in mammals.
After sequencing all orexin receptor exons, one variation (rs2271933) in the OX1R (show HCRTR1 Proteins) gene and one variation (rs2653349) in the OX2R gene were found. However, no significant differences were found in either genotypic or allelic frequency distributions between the two study groups
This study showed that Lack of Association between Genetic Polymorphism of ox2r gene with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population
G-protein-dependency of OX2 receptor (show CD200R1 Proteins) signalling
Several single nucleotide polymorphisms (SNPs) in HCRTR2 were nominally associated with Antipsychotic-induced weight gain (AIWG) in patients of European ancestry treated with either clozapine or olanzapine. None of the SNPs in HCRTR1 (show HCRTR1 Proteins) were associated with AIWG.
Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation is highly unlikely to be caused by mutations in the exons of the HCRTR2 gene.
The study determined structures of OX1R (show HCRTR1 Proteins) bound to the OX1R (show HCRTR1 Proteins)-selective antagonist SB-674042 and the dual antagonist suvorexant at 2.8-A and 2.75-A resolution and explored mechanisms of antagonist the subtype selectivity between OX1R (show HCRTR1 Proteins) and OX2R.
our meta-analysis provides genetic evidence for a role of HCRTR2 in cluster headache
Heart failure patients with minor allele for rs7767652, upstream of hypocretin (orexin) receptor-2 (HCRTR2), were less likely to have improved left ventricular function and a lower prevalence of ejection fraction >35%
the nonsynonymous rs2653349 single nucleotide polymorphism (SNP) (located on the gene that encodes orexin [hypocretin] receptor 2) was selected as the most notable SNP associated with Fagerstrom Test for Nicotine Dependence.
Antibodies from vaccine-associated narcolepsy sera cross-reacted with both influenza nucleoprotein and hypocretin receptor 2.
Study demonstrated that activation of the OX1 (show NQO1 Proteins) receptor in the ventrolateral periaqueductal gray of mice can initiate an endocannabinoid-CB1 (show CNR1 Proteins) receptor-mediated analgesia. Activation of the OX2 receptor (show CD200R1 Proteins) in the ventrolateral periaqueductal gray was also antinociceptive but this antinociceptive effect is CB1 (show CNR1 Proteins) receptor-independent.
Elevation levels of OX1R (show HCRTR1 Proteins) and OX2R (show CD200R1 Proteins) following experimental autoimmune encephalomyelitis induction suggest that alteration in orexinergic system may involve in pathogenesis of multiple sclerosis.
In an heart failure model, HCRTR2-deficient mice exhibited poorer cardiac function, worse treadmill exercise capacity, and greater myocardial scarring
orexin activation of OX2R (show CD200R1 Proteins) in the brain centrally enhances bone formation by lowing circulating leptin (show LEP Proteins) level.
OX2R (show CD200R1 Proteins) activation induces PKC-mediated ERK (show EPHB2 Proteins) and CREB (show CREB1 Proteins) phosphorylation.
In the hypothalamus, the OX2 receptors have an inhibitory role in modulating basal concentrations of NE, ACh, and Hist. In the prefrontal cortex, the evoked release of the monoamines NE, 5-HT, and DA seems to be controlled negatively by OX2 receptors.
results indicate that hcrtr1 (show HCRTR1 Proteins) and 2 signaling oppose one another in the regulation of depression-like behaviors.
Mice lacking OX2R (show CD200R1 Proteins) signaling had poor maintenance of wakefulness indicative of sleepiness and fragmented sleep and lacked any electrophysiological response to orexin-A in the wake-promoting neurons of the tuberomammillary nucleus.
activation of orexin neurons through OX2R (show CD200R1 Proteins) might have an important role in the maintenance of arousal.
Regulation of sleep/wake states is completely achieved by OX(2)R-expressing neurones without involving H(1)R-mediated pathways. Maintenance of basal physiological sleep/wake states is fully achieved without both H(1) and OX(1 (show NQO1 Proteins)) receptors.
Immunoreactivity (IR) for both orexins A and B (OXA and OXB), and cognate receptors (OX1R (show HCRTR1 Proteins) and OX2R) were identified only in the excretory striated (show NSDHL Proteins) ducts of the MSG while acinar cells were not immunoreactive.
Data demonstrated the presence of OX1R (show HCRTR1 Proteins) and OX2R genes and proteins in the ovary of the pig and the impact of the hormonal milieu on the expression of both receptors.
expression of OX1R (show HCRTR1 Proteins) and Ox2R in hypothalamus during oestrous cycle; evidence OX1R (show HCRTR1 Proteins) and OX2R mRNAs and proteins occur in hypothalamic structures engaged in control of reproduction; indicate dependence of OXR expression on endocrine reproductive state
findings provide the first evidence that orexin receptors 1 and 2 messenger RNAs and proteins occur in the pituitary of the pig and indicate the dependence of orexin receptor expression on the endocrine reproductive state
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A.
orexin receptor type 2
, hypocretin (orexin) receptor 2
, orexin receptor type 2-like
, hypocretin receptor 2
, orexin receptor 2
, hcrt receptor
, hypocretin orexin receptor
, hypocretin receptor
, hypocretin receptor type 2
, orexin type-2 receptor
, hypocretin/orexin (Hcrt) receptor 2