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Neuropeptide Y mRNA content decreased 6 h after a meal, but increased to prefeeding levels by 24 h.
Genetic risk score (GRSNPY) analysis found twelve significant (P<0.05) serum NPY concentration related SNPs among alpha7 nicotinic acetylcholine receptor gene CHRNA7 (show CHRNA7 Proteins), insulin receptor (show INSR Proteins) gene INSR (show INSR Proteins), leptin receptor (show LEPR Proteins) gene LEPR (show LEPR Proteins), glucocorticoid receptor (GR (show NR3C1 Proteins)) gene NR3C1 (show NR3C1 Proteins), and NPY gene. However, after permutation test of gene score the predictive value of GRSNPY remained non-significant (P=0.078). CONCLUSIONS: Serum NPY level ...
In obese males, the rs164147 polymorphism of the NPY gene is associated with leptin, insulin level, HOMA-IR, and an increased risk of MetS and its related phenotypes, such as central obesity and hyperglycemia.
Both structural (+1128T/C) and promoter polymorphisms (-399 T/C) of Neuropeptide Y are strongly associated with type-II diabetes susceptibility in Gujarat population which at least in part, may result in higher levels of Neuropeptide Y thereby suggesting its crucial role in type-II diabetes susceptibility.
Hypermethylation of WIF1 (WNT inhibitory factor 1 (show WIF1 Proteins)) and NPY (neuropeptide Y) genes was significantly higher in tumor tissue compared to normal tissue, independently of tumor stage.
Our results provided clinical evidences for NPY participating in the bone healing process in a nonhypothalamic manner, most probably by directly promoting osteogenesis of mesenchymal stem cells.
In conclusion, the obtained results demonstrate the probable role of NPY SNPs in susceptibility to multiple sclerosis within the Iranian population.
Neuropeptide Y is the best dipeptidyl peptidase 4 (DPP4 (show DPP4 Proteins))-substrate in blood, being truncated by soluble and membrane DPP4 (show DPP4 Proteins), respectively. The decline of soluble DPP4 (show DPP4 Proteins) in acute depression could be reversed upon anti-depressive treatment.
study implicates NPY as a potential target in antihypertensive therapies for preeclampsia patients
NPY is efficiently cleaved by FAP indicating a potential function for FAP in neuropeptide regulation within liver and cancer biology.
NPY plays important roles in the pathogenesis and pathophysiology of pituitary adenomas, as shown in this clinical study.
NPY deficient mice had significantly impaired Hematopoietic stem/progenitor cell (HSPC (show PSMA7 Proteins)) mobilization due to increased expression of HSPC (show PSMA7 Proteins) maintenance factors by reduction of matrix metalloproteinase-9 (MMP-9 (show MMP9 Proteins)) activity in bone marrow.
These results identify SK3 (show KCNN3 Proteins) as a key intrinsic mediator that coordinates nutritional status with AgRP (show AGRP Proteins)/NPY neural activities and animals' feeding behavior and energy metabolism.
The vasoconstrictive mechanism has been identified as neuropeptide Y acting on Y1 receptors.
Findings suggest that neuropeptide Y is expressed by distinct populations of neurons can modulate afferent and efferent projections of the central amygdala via presynaptic Y2 receptors located at inhibitory and excitatory synapses.
arcuate nucleus NPY neuropathway to the paraventricular nucleus and dorsomedial hypothalamus is pivotal in obesity-induced elevations in sympathetic nerve activity.
NPY promotes airway hyperresponsiveness through the induction of Rho kinase activity and phosphorylation of myosin light chain, which induces airway smooth muscle contraction.
stress alters CA1 (show CA1 Proteins) circuit function through the impairment of endogenous NPY release, potentially contributing to heightened anxiety
Npy expression is decreased in the cingulate cortex following chronic unpredictable stress.
The results showed that NPY system activity is increased in a time- and space-dependent manner during bone repair.
Decreased neuropeptide Y (NPY) expression in the extended amygdala might be causally linked with the depression induced following type 2 diabetes and that the antidepressant action of imipramine in diabetic mice might be mediated by NPY-NPY Y1 receptor system.
Results show that the PP-fold is not important for recognition of peptide YY or neuropeptide Y at Y receptors.
NPY has a positive inotropic effect in isolated rat cardiac myocytes, which involves increase in Ca2 (show CA2 Proteins)+ release after activation of Y1 NPY receptor
High dietary copper appears to increase feed intake and promote weight gain by enhancing NPY concentration and NPY mRNA expression level in the hypothalamus of pigs.
Neuropeptide Y was released from the lung tissue of brain-dead pigs, and its concentration was related to the extent of neurogenic pulmonary edema
Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin (show LEP Proteins)-NPY and insulin (show INS Proteins) signaling pathways.
Data indicate that increased body weight gain during juvenile development accelerates sexual maturation in heifers, coincident with reciprocal changes in circulating concentrations of leptin (show LEP Proteins) and hypothalamic neuropeptide Y (NPY) release.
There is a strong association between putative favorable allelic variants (SNP) of neuropeptide Y, leptin (show LEP Proteins), and IGF-1 (show IGF1 Proteins) genes, and residual feed intake, when animals were grazing on a high-quality, high-availability pasture.
The NPY SNP (NPY1) was associated with the prevalence of the animal being in calf 100 d after calving and 305-d milk yield in the first lactation.
NPY tended to increase serum growth hormone (show GH1 Proteins), which appeared to be a consequence of increased pulse amplitude. Infusion of NPY also increased CSF (show CSF2 Proteins) growth hormone-releasing hormone (show GHRH Proteins).
Data show that PKA and PKC pathways are involved in the differential regulation of production of the neuropeptides (Met)enkephalin, galanin (show GAL Proteins), somatostatin (show SST Proteins), NPY, and VIP (show Vip Proteins).
The present investigation provides results of increased vasocontractile effect of NOR and decreased enhancing effect of NPY on NOR vasoconstriction in the rabbit facial artery after carotid occlusion that is related to altered endothelium function
NPY acts as an orexigenic factor in the zebrafish.
Neuropeptide Y/peptide YY receptor Y2 duplicate in zebrafish with unique introns displays distinct peptide binding properties.(
Developmental expression of zYb and zYc receptors suggests a role for neuropeptide Y (NPY) in organogenesis.
In this study described the the lateral line presence of NPY-like immunoreactivity (IR) in of the Antarctic nototheniod fish. Differences in size and cellular composition between the two neuromasts were presen NPY immunoreactivity.
A 2-day fast increased NPY gene expression in the supraoptic nucleus and paraventricular nucleus.
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases.
, neuropeptide Ya
, prepro-neuropeptide Y
, pro-neuropeptide Y
, pro-neuropeptide Y preproprotein
, neuropeptide Yb
, pre-pro hormone
, preproneuropeptide Y, preproNPY