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The present study demonstrated a possible association of target P300 (show EP300 Proteins) evoked theta and of alcohol dependence with SNPs from the gene SGIP1 in the region of rs10889635, but further studies are required.
crystal structures of the SGIP1 mu homology domains in complex with peptides containing two DPF motifs, are reported.
Our results show association between genetic variants in SGIP1 and fat mass. We provide evidence that variation in SGIP1 is a potentially important determinant of obesity-related traits in humans
The earlier implicated single nucleotide polymorphisms located in SGIP1 gene showed no association with alcohol dependence or theta electroencephalogram power.
SGIP1 and the signaling adaptor Reps1 interact with ITSN1 in vivo.
SGIP1alpha plays an essential role in clathrin-mediated endocytosis by interacting with phospholipids and Eps15 (show EPS15 Proteins).
Study showed that SGIP1 prevents the endocytosis of activated CB1R (show CNR1 Proteins) and that it alters signaling via the CB1R (show CNR1 Proteins) in a biased manner. CB1R (show CNR1 Proteins) mediated G-protein activation is selectively influenced by SGIP1, beta-arrestin associated signaling is changed profoundly, most likely as a consequence of the prevention of the receptor's internalization elicited by SGIP1.
SGIP1 is an important and novel member of the group of neuronal molecules required for the regulation of energy homeostasis
SGIP1 functions as an endocytic protein that affects signaling by receptors in neuronal systems involved in energy homeostasis via its interaction with endophilins (see SH3GL3\; MIM 603362) (Trevaskis et al., 2005
SH3-containing GRB2-like protein 3-interacting protein 1
, endophilin-3-interacting protein
, SH3-domain GRB2-like interacting protein 1 alpha