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CHPF (show CHPF Proteins) was found to be differentially methylated in human squamous cell carcinomas.
study reports a novel protein named Klokin 1(a splice variant of chondroitin polymerizing factor (show CHPF Proteins)) that transports Parkin (show PARK2 Proteins) to the mitochondria; findings indicate that mitochondrial Parkin (show PARK2 Proteins) prevents mitochondrial depolarization and that Klokin 1 may compensate for Parkin (show PARK2 Proteins) deficiency
Chondroitin sulfate synthase-2/chondroitin polymerizing factor (show CHPF Proteins) has two variants with distinct function
chondroitin polymerizing activity requires concomitant expression of a ChPF (show CHPF Proteins) with ChSy (show CHSY1 Proteins); coexpression of the ChPF (show CHPF Proteins) and ChSy (show CHSY1 Proteins) yielded markedly augmented glycosyltransferase (show GTDC2 Proteins) activities, whereas simple mixing of the two separately expressed proteins did not.
The full-length open reading frame consists of 882 amino acids and encodes a typical type II membrane protein. This enzyme contains a beta (show SUCLA2 Proteins) 3-glycosyltransferase (show GTDC2 Proteins) motif and a beta (show SUCLA2 Proteins) 4-glycosyltransferase (show GTDC2 Proteins) motif similar to that found in CSS1 (show CAPNS1 Proteins).
results suggest that chondroitin polymerization is achieved by multiple combinations of chondroitin synthase-1 (show CHSY1 Proteins), chondroitin synthase-2, and chondroitin-polymerizing factor (show CHPF Proteins)
CSS3 is a glycosyltransferase that has both glucuronyltransferase and N-acetylgalactosaminyltransferase activities (Yada et al., 2003
, chondroitin sulfate synthase 3
, N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II
, N-acetylgalactosaminyltransferase 2
, chondroitin glucuronyltransferase 2
, chondroitin sulfate synthase 2
, chondroitin-polymerizing factor
, glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II
, N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 3
, N-acetylgalactosaminyltransferase 3
, carbohydrate synthase 2
, chondroitin glucuronyltransferase 3
, chondroitin synthase 2