Browse our Hyaluronan Synthase 2 (HAS2) ELISA Kits

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Hyaluronan Synthase 2 ELISA Kits (HAS2)
On www.antibodies-online.com are 20 Hyaluronan Synthase 2 (HAS2) ELISA Kits from 8 different suppliers available. Additionally we are shipping Hyaluronan Synthase 2 Antibodies (57) and Hyaluronan Synthase 2 Proteins (5) and many more products for this protein. A total of 83 Hyaluronan Synthase 2 products are currently listed.
Synonyms:
DG42, Has2, XHas2

More ELISA Kits for Hyaluronan Synthase 2 Interaction Partners

Zebrafish Hyaluronan Synthase 2 (HAS2) interaction partners

  1. Fgf signaling is required early, from 6 to 10h pf,for has2 activation. Loss of has2 results inthe loss of the chondrogenic program resulting in postchordal neurocranial defects in Fgf loss-of-function embryos. Shh (show SHH ELISA Kits) is not essential for this early activation of has2.

  2. propose here a rather unique role of Med10 (show MED10 ELISA Kits) in orchestrating cardiac valve formation by mediating Foxn4 (show FOXN4 ELISA Kits) dependent tbx2b transcription, expression of Has2 and subsequently proper development of the cardiac jelly

  3. identify Npnt (show NPNT ELISA Kits) as a novel upstream regulator of Bmp4 (show BMP4 ELISA Kits)-Has2 signaling that plays a crucial role in AV canal differentiation

  4. MiR-23 is both necessary and sufficient for restricting the number of endocardial cells that differentiate into endocardial cushion cells by inhibiting Has2 and extracellular hyaluronic acid production.

  5. data demonstrate that elevated glucose alone induces cardiac defects in zebrafish embryos by altering the expression pattern of tbx5 (show TBX5 ELISA Kits), tbx20 (show TBX20 ELISA Kits), and has2 in the hear

Mouse (Murine) Hyaluronan Synthase 2 (HAS2) interaction partners

  1. Expression of the innate immune receptor Toll-like receptor 4 (TLR4 (show TLR4 ELISA Kits)) and the extracellular matrix glycosaminoglycan hyaluronan (HA) on type 2 alveolar epithelial cells (AEC@2) are important for AEC2 renewal, repair of lung injury and limiting the extent of fibrosis. Either deletion of TLR4 (show TLR4 ELISA Kits) or HA synthase 2 in surfactant-protein-C (show SFTPC ELISA Kits)-positive AEC2s leads to impaired renewal capacity, severe fibrosis and mortality.

  2. Has2 mRNA was expressed in the surrounding mesenchyme from E12.0 to 18.0 in both molar and incisor tooth germs, but disappeared after birth.

  3. the ineffective repair of injured cartilage in Has1 (show HAS1 ELISA Kits)(-/-) joints can be at least partly explained by the markedly enhanced expression of particular genes in pathways linked to ECM (show MMRN1 ELISA Kits) turnover, IL-17 (show IL17A ELISA Kits)/IL-6 (show IL6 ELISA Kits) cytokine signaling, and apoptosis.

  4. these results highlight the role of nSMase2 in apoptosis evoked by nutrient starvation that could contribute to the delayed apoptosis of hypertrophic chondrocytes in the growth plate, and emphasize the antiapoptotic properties of HAS2

  5. mir (show MLXIP ELISA Kits)-23a-3p causes cellular senescence by targeting hyaluronan synthase 2: possible implication for skin aging.

  6. Has2 expression and hyaluronan produced at the tips of epithelial cells play a critical role in driving tubulogenesis and branching in vitro.

  7. Hyaluronan synthase 2 has a role in protecting skin fibroblasts against apoptosis induced by environmental stress

  8. Stimulation with LPS (show TLR4 ELISA Kits) caused rapid increases in versican (show Vcan ELISA Kits) mRNA and protein, a rapid increase in Has1 (show HAS1 ELISA Kits) mRNA, and concomitant inhibition of hyaluronidases 1 and 2, the major hyaluronan degrading enzymes

  9. This study demonistrated that Has2 expression in adult mouse subventricular zone and rostral migratory stream and in ischemic cortex.

  10. This study identifies Has2 as a novel downstream target of Shh (show SHH ELISA Kits) signaling required for joint patterning and chondrogenesis.

Human Hyaluronan Synthase 2 (HAS2) interaction partners

  1. Reduced expression of HAS1 (show HAS1 ELISA Kits) and HAS2 is associated with melanoma progression and suggests that HAS1 (show HAS1 ELISA Kits) and HAS2 have a prognostic significance in cutaneous melanoma.

  2. Results demonstrate that hypoxia induces HAS2 expression and thereby HA production, which contributes to EMT (show ITK ELISA Kits) of oral squamous cell carcinoma. This process is mediated by HAS2-AS1 (show PTGDR ELISA Kits), which can bind to HAS2 gene inducing its transcription.

  3. We identified HAS2, tumor cell-derived hyaluronic acid (HA) and ZEB1 (show ZEB1 ELISA Kits) to form a positive feedback loop as ZEB1 (show ZEB1 ELISA Kits), elevated by HA, directly activates HAS2 expression in breast cancer

  4. The present data reveal a selective up-regulation of HAS2 expression by extracellular Uridine Triphosphate, which is likely to contribute to the previously reported rapid activation of hyaluronan metabolism in response to tissue trauma or ultraviolet radiation.

  5. HAS2 and HAS3 (show HAS3 ELISA Kits) were the only hyaluronan synthases detected, the expression of which was almost similar in NPs (show NPS ELISA Kits) and NM.

  6. HAS2 has been proposed to be a target for therapeutic intervention in cancer. Our findings suggested a possible antagonistic role of androgen receptor (AR (show AR ELISA Kits)) pathway on HAS2 function.

  7. HAS-2 gene silencing may inhibit proliferation and promote apoptosis in the MCF-7 human breast cancer cell line.

  8. Our study establishes HAS2-mediated HA synthesis as a driver of growth of bladder cancer with low AGL (show AGL ELISA Kits) and provides preclinical rationale for personalized targeting of HAS2/HA signaling in patients with low amylo-alpha-1-6-glucosidase-4-alpha-glucanotransferase (show AGL ELISA Kits) -expressing tumors.

  9. HAS2-HA system influences the biological characteristics of human breast cancer cells

  10. Regulation of Hyaluronan (HA) Metabolism Mediated by HYBID (Hyaluronan-binding Protein Involved in HA Depolymerization, KIAA1199 (show KIAA1199 ELISA Kits)) and HA Synthases in Growth Factor-stimulated Fibroblasts.

Xenopus laevis Hyaluronan Synthase 2 (HAS2) interaction partners

  1. In the absence of XHas2, early myoblasts underwent apoptosis, failing to complete their muscle differentiation programme. XHas2 activity is also required for migration of hypaxial muscle cells and trunk neural crest cells (NCC (show SLC12A3 ELISA Kits)).

Hyaluronan Synthase 2 (HAS2) Antigen Profile

Antigen Summary

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.

Alternative names and synonyms associated with Hyaluronan Synthase 2 (HAS2)

  • hyaluronan synthase 2 (has2) Elisa Kit
  • hyaluronan synthase 2 (HAS2) Elisa Kit
  • hyaluronan synthase 2 (LOC100228837) Elisa Kit
  • hyaluronan synthase 2 (Has2) Elisa Kit
  • hyaluronan synthase 2 (SHAS2) Elisa Kit
  • DG42 Elisa Kit
  • Has2 Elisa Kit
  • XHas2 Elisa Kit

Protein level used designations for Hyaluronan Synthase 2 (HAS2) ELISA Kits

hyaluronan synthase 2 , hyaluronic acid synthase 2 , HA synthase 2 , hyaluronan synthase homolog , hyaluronate synthase 2 , CHAS2 , xHAS2

GENE ID SPECIES
260350 Danio rerio
472850 Pan troglodytes
482032 Canis lupus familiaris
100008626 Oryctolagus cuniculus
100009708 Equus caballus
100145711 Xenopus (Silurana) tropicalis
100228837 Taeniopygia guttata
15117 Mus musculus
25694 Rattus norvegicus
3037 Homo sapiens
281220 Bos taurus
395594 Gallus gallus
397120 Sus scrofa
399146 Xenopus laevis
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