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HS3ST2 and CCNA1 (show CCNA1 Proteins) genes may play important roles in HPV-induced cervical cancer and patients with specific hypermethylated genes may have a greater risk of progressing to invasive cervical cancer.
By interacting with tau at the intracellular level, the 3-O-sulphated heparan sulphates produced by HS3ST2 might act as molecular chaperones allowing the abnormal phosphorylation of tau
HS3ST2 hypermethylation may be an independent prognostic indicator for overall survival in node-negative stage I-II NSCLC
These results showed that silencing of 3-OST-2 was present in a wide range of human cancersFrom the high incidence, silencing of the 3-OST-2 gene is expected to have high diagnostic, and potentially therapeutic, values.
results raise the possibility of a role of 3-OST-2 in the spread of HSV-1 infection in the brain
3-OST-2 and 3-OST-4 (show HS3ST4 Proteins) are the major neural gD-type 3-OSTs, and so are prime candidates for participating in HS-dependent neurobiologic events.
The 3OST-2 and -4 are specifically expressed in brain.
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. This gene is expressed predominantly in brain and may play a role in the nervous system.
heparan sulfate 3-O-sulfotransferase 2
, heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2
, heparan sulfate glucosamine 3-O-sulfotransferase 2
, heparin-glucosamine 3-O-sulfotransferase