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Tumor-free mice and mice with B16 melanoma have differential proteolytic fragments of serum ITIH4.
this report has further supported for associations of genetic variants in the ITIH4 and CALN1 (show CALN1 Proteins) genes with schizophrenia and provided the first evidence that the variants regulate ITIH4 AND CALN1 (show CALN1 Proteins) expression in the dorsolateral prefrontal cortex
confirmed the association of schizophrenia with ITIH3/4 in a Han Chinese population
ITIH4 peptide isoform as a preterm birth biomarker and its associated SNP implications
Serum ITIH4 may be a PM10-specific biomarker in COPD (show ARCN1 Proteins) and may be related to inflammation.
Four novel body mass index-associated loci near the KCNQ1 (show KCNQ1 Proteins)(rs2237892), ALDH2 (show ALDH2 Proteins)/MYL2 (show MYL2 Proteins) (rs671, rs12229654), ITIH4 (rs2535633) and NT5C2 (show NT5C2 Proteins) (rs11191580) genes are identified in East Asian-ancestry populations.
Worse survival among HCC (show FAM126A Proteins) patients with low ITIH4.
Isoform-specific ITIH4 glycosylation and utilization of O-glycosylation sites on ITIH4 differs between cell lines and serum.
A novel association between suicide attempt and the ITIH3 (show ITIH3 Proteins)/4-region in a combined group of patients with bipolar disorder, schizophrenia and related psychosis spectrum disorders.
Expression of the 85 kDa ITIH4 was substantial in amyotrophic lateral sclerosis compared with controls or patients with muscular dystrophy, Alzheimer diseases, or Parkinson diseases
A truncated fragment of inter-alpha-trypsin inhibitor heavy chain 4 was the sole protein found to be significantly enhanced in the prostate cancer patients compared to the controls.
Promoter of ITIH4 major acute phase protein has been isolated, cloned, and proven functional by response to an inflammatory stimulus (interleukin-6 (show IL6 Proteins)) in human Hep3B cells. (inter-alpha-trypsin heavy chain 4; ITIH4)
The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene.
ITI heavy chain H4
, inter-alpha-inhibitor heavy chain 4
, inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)
, inter-alpha-trypsin inhibitor family heavy chain-related protein
, inter-alpha-trypsin inhibitor heavy chain H4
, inter-alpha-trypsin inhibitor, heavy chain-like, 1
, plasma kallikrein-sensitive glycoprotein 120
, inter alpha-trypsin inhibitor, heavy chain 4
, inter-alpha-inhibitor H4 heavy chain
, major acute phase protein