Browse our ITIH5 Proteins (ITIH5)

Full name:
Inter alpha Globulin Inhibitor H5 Proteins (ITIH5)
On are 9 Inter alpha Globulin Inhibitor H5 (ITIH5) Proteins from 4 different suppliers available. Additionally we are shipping ITIH5 Antibodies (27) and ITIH5 Kits (10) and many more products for this protein. A total of 49 ITIH5 products are currently listed.
4631408O11Rik, 5430408M01Rik, E130106B02, ITI-HC5
list all proteins Gene Name GeneID UniProt
ITIH5 209378 Q8BJD1
ITIH5 80760 Q86UX2

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ITIH5 Proteins (ITIH5) by Origin

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More Proteins for ITIH5 Interaction Partners

Mouse (Murine) Inter alpha Globulin Inhibitor H5 (ITIH5) interaction partners

  1. indicate an additional and specific role of this gene in the female reproductive tract, and furthermore reinforces ITIH5 as a putative candidate gene for MRKH syndrome.

Human Inter alpha Globulin Inhibitor H5 (ITIH5) interaction partners

  1. Low ITIH5 expression is associated with liver metastasis in pancreatic cancer.

  2. This is the first study so far showing a putative tumor suppressive function of ITIH5 in cervical carcinogenesis.

  3. The current study describes a novel mechanism linking the TSG-6 (show TNFAIP6 Proteins) transfer of the newly described HC5 (show PSMB1 Proteins) to the HA-dependent control of cell phenotype. The interaction of HC5 (show PSMB1 Proteins) with cell surface HA was essential for TGFbeta1 (show TGFB1 Proteins)-dependent differentiation of fibroblasts to myofibroblasts, highlighting its importance as a novel potential therapeutic target.

  4. ITIH5 may be a novel putative tumor suppressor gene in NSCLC with a potential molecular significance in the squamoid ADC (show ADC Proteins) subtype and further clinical impact for risk stratification of adenocarcinoma patients.

  5. Hence, we can strengthen the presumption that ITIH5 may constitute a novel regulatory molecule of the human skin that could play an important role in in fl ammation via its interaction with hyaluronic acid.

  6. ITIH5 expression is decreased in gastric cancer and that low expression of this protein is associated with poor clinical outcome.

  7. ITIH5 is a novel putative tumor suppressor gene in colon cancer with a potential impact in the CIMP-related pathway.

  8. Tumor-specific methylation of the three-gene panel (ITIH5, DKK3, and RASSF1A (show RASSF1 Proteins)) might be a valuable biomarker for the early detection of breast cancer.

  9. provide evidence that down-regulation of ITIH5 by aberrant DNA hypermethylation may provoke invasive phenotypes in human bladder cancer

  10. ITIH5 gene expression is regulated both by obesity and by the region between visceral and subcutaneous adipose tissue.

ITIH5 Protein Profile

Protein Summary

This gene encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor (ITI) family members. ITI proteins are involved in extracellular matrix stabilization and in the prevention of tumor metastasis. They are also structurally related plasma serine protease inhibitors and are composed of a light chain and varying numbers of heavy chains. This family member is thought to function as a tumor suppressor in breast and thyroid cancers. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with ITIH5

  • inter-alpha (globulin) inhibitor H5 (Itih5)
  • inter-alpha-trypsin inhibitor heavy chain family, member 5 (ITIH5)
  • 4631408O11Rik protein
  • 5430408M01Rik protein
  • E130106B02 protein
  • ITI-HC5 protein

Protein level used designations for ITIH5

ITI heavy chain H5 , ITI-HC5 , inter-alpha trypsin inhibitor heavy chain precursor 5 , inter-alpha-inhibitor heavy chain 5 , inter-alpha-trypsin inhibitor heavy chain H5 , inter-alpha (globulin) inhibitor H5 , inter-alpha trypsin inhibitor heavy chain 5

209378 Mus musculus
80760 Homo sapiens
534787 Bos taurus
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