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Human SDC4 Protein expressed in Escherichia coli (E. coli) - ABIN668053
Woods, Couchman: Syndecan 4 heparan sulfate proteoglycan is a selectively enriched and widespread focal adhesion component. in Molecular biology of the cell 1994
Show all 2 references for ABIN668053
Mouse (Murine) SDC4 Protein expressed in Human Cells - ABIN2008245
Bass, Humphries: Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor signalling. in The Biochemical journal 2002
We show here that sdc2 (show SDC2 Proteins),sdc3 (show SDC3 Proteins) and sdc4 are expressed in the zebrafish embryonic brain during the major period of axon growth. These genes show differing expression patterns in the brain which provides putative insights into their functional specificity.
cell adhesion properties of syndecan-4 are consistent across the vertebrate spectrum and reflect an early acquisition of specialization after syndecan (show SDC1 Proteins) gene duplication events at the invertebrate/early chordate boundary
Dynamic changes in syndecan-4- and glypican-1 (show GPC1 Proteins)-positive satellite cells indicate that they are differentially expressed during myogenesis.
The cytoplasmic domain of syndecan-4 is required for cell migration and RhoA (show RHOA Proteins) activation in skeletal muscle satellite cells.
results suggest that syndecan-4 and its side chains play important roles in regulating FAK (show PTK2 Proteins) activity, and PKCalpha (show PKCa Proteins) and beta1-integrin cell membrane localization, but not cell apoptosis and vinculin (show VCL Proteins)-containing focal adhesion formation in satellite cells
These data suggested that expression of the myogenic regulatory transcription factors are dependent upon expression of glypican-1 (show GPC1 Proteins) and syndecan-4 during satellite cell proliferation and differentiation, and Pax7 (show PAX7 Proteins) expression is influenced by glypican-1 (show GPC1 Proteins).
syndecan-1 (show SDC1 Proteins), syndecan-4, or glypican-1 (show GPC1 Proteins) differentially affect the processes of turkey muscle cell proliferation and differentiation, and can regulate these developmental stages in an FGF2 (show FGF2 Proteins)-independent manner
Study has demonstrated that SDC-4 expression was increased in sera and skin of atopic dermatitis (AD) patients, suggesting that SDC-4 may contribute to the development of AD.
the present study demonstrated that synd4 was involved in the chemotactic migration of ECs in vitro and in vivo.
results suggest that SDC4 alleles affect lipid profile in elderly subjects and may in part mediate the link between LDL-C and longevity.
Synd4 shedding is a molecular pathological alteration in the development and maintenance of inflammation-associated atrial fibrillation.
Syndecan-4 is essential for transmitting the mechanotransduction signals via activation of PKC-alpha and is important for tumor cells spreading, assembly of actin cytoskeleton and cell contractility.
demonstrate that HER2 (show ERBB2 Proteins) is captured via a site, comprised of amino acids 210-240, in the extracellular domain of human Sdc1 (show SDC1 Proteins), and EGFR (show EGFR Proteins) is captured via an extracellular site comprised of amino acids 87-131 in human Sdc4
Dynamic catch of a Thy-1 (show THY1 Proteins)-integrin alpha5beta1+syndecan-4 trimolecular complex explains extraordinary cancer cell adhesion to the vascular endothelium.
Syndecan-4 polymorphisms were associated with essential hypertension, body mass index, and coronary artery disease prevalence in the Tampere adult population cardiovascular risk study.
No association was found with SDC4 and breast cancer.
Data indicate that depletion of syndecan 4 (S4) in umbilical vein endothelial cells (HUVECs) using shRNA inhibited flow-induced alignment in vitro, which was rescued by re-expression of S4.
Data show that differentiative switches between bronchiolar progenitors and club cells are under the Nrf2 (show NFE2L2 Proteins)-mediated control of SLPI (show SLPI Proteins) and syndecan 4.
Shedding of syndecan-4 promotes immune cell recruitment and mitigates cardiac dysfunction after lipopolysaccharide challenge in mice.
SDC4 plays an important role in asthma induction. Disturbed SDC4 signalling leads to an impaired motility and directional migration of antigen-presenting dendritic cells.
Syndecan-4 exerts a dual role in collagen cross-linking, one involving its cytosolic domain and calcineurin (show PPP3CA Proteins)/nuclear factor of activated T-cells signalling leading to collagen
Locally generated Sdc4 may play a role in regulating TRPC6 (show TRPC6 Proteins) channels, and may contribute to glomerular pathology.
Sdc4 contributes to the development of collagen induced arthritis by promoting germinal center formation and autoantibody production through its regulation of SDF-1 (show CXCL12 Proteins)-mediated B cell migration.
binding interaction between syndesmos (show NUDT16L1 Proteins) and syn4 (show STX4 Proteins)(cyto) was characterized as a low-affinity interaction (Kd = 62 muM) by surface plasmon resonance and nuclear magnetic resonance
the crucial role of SDC-4 for neuron density, neurite length, and branches.
SDC4 participates in amelogenesis, and FGF10 (show FGF10 Proteins) may modulate dental epithelial cell behaviors through the regulation of SDC4 expression.
Findings suggest that syndecan-4 may be involved in acquisition of resistance to detachment-induced cell death (anoikis resistance) in endothelial cells, thus contributing to cell transformation.
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22.
, ryudocan core protein
, syndecan 4 like
, heparan sulfate proteoglycan
, syndecan 4 (amphiglycan, ryudocan)
, ryudocan amphiglycan
, syndecan proteoglycan 4
, Ryudocan/syndecan 4