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study illustrates the power of next-generation sequencing in the discovery of new genetic variants and a significant ethnic diversity in the ST3GAL4 gene
ST3GAL IV affects apoptotic signal, cell proliferation and the effectiveness of imatinib treatment in chronic myeloid leukemia (show BCL11A Proteins) cells.
TNF (show TNF Proteins)-responsive element in an intronic region of the ST3GAL4 gene, whose TNF (show TNF Proteins)-dependent activity is repressed by ERK/p38 (show MAPK1 Proteins) and MSK1 (show RPS6KA5 Proteins)/2 inhibitors. This TNF (show TNF Proteins)-responsive element contains potential binding sites for ETS1 (show ETS1 Proteins) and ATF2 (show ATF2 Proteins) transcription factors related to TNF (show TNF Proteins) signaling.
Expression levels of sialyltransferases ST3GAL1 (show ST3GAL1 Proteins) and ST3GAL4 were upregulated in the HRMECs after high-glucose stimulation.
There may be a racial/ethnic-specific association, and/or sex-specific association between the ST3GAL4 rs11220462 SNP and serum lipid parameters in some ethnic groups.
ST3Gal-4 is the primary sialyltransferase regulating the synthesis of E-, P-, and L-selectin (show SELL Proteins) ligands on human myeloid leukocytes
The polymorphism analysis showed that at SNP rs10893506, genotypes CC and CT of the ST3GAL4 B3 promoter were associated with the presence of premalignant lesions and cervical cancer.
the role of ST3Gal IV in the acquisition of adhesive, migratory and metastatic capabilities and, secondly, in analyzing the expression of ST3Gal III (show ST3GAL3 Proteins) and ST3Gal IV in pancreatic adenocarcinoma tissues, was investigated.
The expression of ST3GAL4 leads to SLe(x) antigen expression in gastric cancer cells which in turn induces an increased invasive phenotype through the activation of c-Met
TNF (show TNF Proteins) increases the expression of alpha2,3-sialyltransferase (show ST3GAL5 Proteins) gene ST3GAL4
The results of this study indicated that ST3Gal IV is a key molecule in the mechanisms underlying anxiety - a side effect of TLE - and may therefore also be an effective target for treating epilepsy, acting through the same circuits.
St3Gal4-deficient myeloid cells had less binding of Ccl5 (show CCL5 Proteins) and impaired Ccl5 (show CCL5 Proteins)-triggered integrin activation. St3Gal4 deficiency reduced the size, stage, and inflammatory cell content of atherosclerotic lesions in Apoe (show APOE Proteins)(-/-) mice on high-fat diet.
St3gal4, potentially involved in antithrombin (show SERPINC1 Proteins) sialylation, was 85% lower in neonates in comparison with adults
Expression of the sialyltransferase, ST3Gal4, impacts cardiac voltage-gated sodium channel activity, refractory period and ventricular conduction.
Coordinated participation of both ST3Gal-VI (show ST3GAL6 Proteins) and ST3Gal-IV in the synthesis of functional selectin ligands.
Data show that the sialyltransferase enzymes St6gal1 (show ST6GAL1 Proteins) and St3gal4 are responsible for the production of sialyllactose in mouse milk.
Regulates P-selectin (show SELP Proteins) ligand protein, the molecule responsible for L-selectin (show SELL Proteins)-mediated leukocyte interactions in inflammation.
Sialylation by ST3Gal-IV significantly contributes to CXCR2 (show CXCR2 Proteins)-mediated leukocyte adhesion during inflammation in vivo.
This gene encodes a member of the glycosyltransferase 29 family, a group of enzymes involved in protein glycosylation. The encoded protein is targeted to Golgi membranes but may be proteolytically processed and secreted. The gene product may also be involved in the increased expression of sialyl Lewis X antigen seen in inflammatory responses. Multiple transcript variants encoding different isoforms have been found for this gene.
, CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
, alpha-2,3-sialyltransferase ST3Gal IV
, alpha 2,3-ST 4
, alpha 2,3-sialyltransferase IV
, beta-galactoside alpha-2,3-sialyltransferase 4
, sialyltransferase 4C (beta-galactosidase alpha-2,3-sialytransferase)
, sialyltransferase 4C (beta-galactoside alpha-2,3-sialytransferase)
, ST3Gal IV
, sialyltransferase 4C
, ST3 beta-galactoside alpha-2,3-sialyltransferase 4