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Casein kinase 1epsilon activates minus-end-directed transport of membrane organelles along microtubules. CK1epsilon functions downstream of protein phosphatase PP2A in the pigment aggregation signaling pathway.
casein kinase I epsilon activity is regulated by Wnt (show WNT2 Proteins) signaling
low CK1epsilon expression is correlated with a low survival rate and CK1epsilon may play a role as a tumor suppressor in hepatocarcinogenesis.
Findings establish CK1varepsilon as a regulator of antiviral innate immune responses and indicate a novel mechanism of immunoregulation that involves CK1varepsilon-mediated phosphorylation of TRAF3 (show TRAF3 Proteins).
CSNK1E expression is associated with disease-free survival in breast cancer patients with wild-type p53 (show TP53 Proteins) or poor histological differentiation or in those without adjuvant chemotherapy.
a 4-locus CSNK1E haplotype encompassing the rs1534891 SNP (Z-score=2.685, permuted p=0.0076) and a 3-locus haplotype in ARNTL (show ARNTL Proteins) (Z-score=3.269, permuted p=0.0011) showed a significant association with Bipolar Disorder
site-specific phosphorylation of adiponectin (show ADIPOQ Proteins), especially at sites targeted by CK1delta in vitro, provides an additional regulatory mechanism for modulating adiponectin (show ADIPOQ Proteins) complex formation and function.
The dynamical and conformational properties for each of three isoforms of CK1 (show CSNK1A1L Proteins) are explored through molecular dynamics (MD) simulations.
The results support our previous report of association of CSNK1E SNP rs1534891 with protection from heroin addiction. CSNK1E interacts with circadian rhythms and DARPP-32 (show PPP1R1B Proteins) and has been implicated in negative regulation of sensitivity to opioids in rodents.
CK1epsilon expression was higher in colorectal cancer tissues vs normal and was correlated with the Dukes staging and depth of invasion. Knockdown reduced cell proliferation and invasion and downregulated wnt3alpha, beta-catenin (show CTNNB1 Proteins), PCNA (show PCNA Proteins) and MMP-9 (show MMP9 Proteins).
Results indicate that changes in the expression levels of casein kinase 1 (show CSNK1A1 Proteins) isoforms CK1delta and DK1epsilon in colorectal tumors correlate with patients' survival.
The loss of cytoplasmic CK1epsilon expression is greatly associated with poor survival and might be an adverse survival factor.
mice bearing a short-period mutation in the enzyme casein kinase 1epsilon (tau mutation), which accelerates free-running circadian cycles, were investigated.
Data indicate period circadian proteins PER1 and PER2 (show PER2 Proteins) as direct substrates of casein kinase 1epsilon (CK1epsilon).
Integrated genetic approaches identify the molecular mechanisms of Sox4 in early B-cell development: intricate roles for RAG1 (show RAG1 Proteins)/2 and CK1epsilon.
CK1 epsilon(tau), as a gain-of-function mutation, acts at a specific circadian phase to promote degradation of PERIOD proteins and thereby accelerate the mammalian clockwork in brain and periphery.
A narrow genetic locus containing Csnk1e is associated with differences in sensitivity to methamphetamine (MA) and fentanyl; variation at the Csnk1e locus can regulate the locomotor response to MA.
Identification of a novel Wnt5a-CK1varepsilon-Dvl2-Plk1-mediated primary cilia disassembly pathway.
The results suggest that CK1delta/epsilon binds to and phosphorylates the N-terminal domain of Dnmt1 (show DNMT1 Proteins) and regulates Dnmt1 (show DNMT1 Proteins) function by reducing the DNA-binding activity.
physical interaction between PER and CKIdelta/epsilon required for circadian rhythm
Cell/organ type-specific function of CK1epsilon indicate that tumorigenic conversion of mammary glands in SV40 T-antigen-transgenic mice leads to downregulation of CK1epsilon.
The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene.
casein kinase I epsilon
, casein kinase 1 epsilon
, discs overgrown
, casein kinase I isoform epsilon
, casein kinase I, epsilon
, casein kinase 1, epsilon
, casein kinase I isoform epsilon-like
, CKI, epsilon
, KC1 epsilon