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Overexpression of GLI2 is associated with osteosarcoma progression.
MALAT1 promotes gastric cancer proliferation and progression. MALAT1 is a direct target of miR (show MLXIP ELISA Kits)-202 and knockdown of MALAT1 significantly decreases the expression of Gli2 by negatively regulating miR (show MLXIP ELISA Kits)-202.
the GLI2 gene may be one of the candidate genes to analyze when an association of pituitary hormone (show CGA ELISA Kits) deficiency and developmental defects in posterior pituitary gland. The highly variable phenotype found suggests the presence of additional unknown factors that could contribute to the phenotype observed in these patients.
the GLI2 protein level could serve as a feasible marker of ligand-dependent hedgehog (show SHH ELISA Kits) activation in pancreatic neoplasms.
ALDH1A1 (show ALDH1A1 ELISA Kits) stabilizes the Gli2 protein in an enzyme-independent manner in hepatocellular cancer.
GLI2 stabilized glial cell missing-a, a pivotal transcriptional factor for trophoblastic syncytialization.
The results do not support our hypothesis that common germline genetic variants in the GLI2 genes is associated with the risk of developing medulloblastoma.
GLI1 (show GLI1 ELISA Kits) and GLI2, but not GLI3 (show GLI3 ELISA Kits) are involved in the regulation of SOX18 (show SOX18 ELISA Kits) gene expression in cervical carcinoma cell lines.
GLI2 mutations typically result in pituitary anomalies with or without postaxial polydactyly.
Rab23 (show RAB23 ELISA Kits) is expressed in breast cancer cells, and ectopic expression of Rab23 (show RAB23 ELISA Kits) inhibits the growth and proliferation as well as induces cell apoptosis in breast cancer cells These effects may be due to the inhibition by Rab23 (show RAB23 ELISA Kits) of Gli1 (show GLI1 ELISA Kits) and Gli2 mRNA expression
Data indicate that the expression levels of transcription factors Gli1 (show GLI1 ELISA Kits) and Gli2 in muscle were the lowest of the 13 tissues.
The 12 SNPs of GLI2 encompassing exon 4 to exon 8 showed strong association with in the anorectal atresia in pigs.
Study suggested that loss of Gli2 mRNA mediated the anterior-restricted defect in conditional Dicer (show DICER1 ELISA Kits) knockdown mice and showed that miR (show MLXIP ELISA Kits)-106b positively regulated Gli2 mRNA expression
Sufu (show SUFUH ELISA Kits) deletion early in embryogenesis resulted in unstable Gli2 and Gli3 (show GLI3 ELISA Kits) activity, leading to the ectopic activation of Shh (show SHH ELISA Kits) signaling.
the three GLI (show GLI1 ELISA Kits) factors(GLI1 (show GLI1 ELISA Kits), GLI2, and GLI3 (show GLI3 ELISA Kits)) in mature hepatocytes form an interactive transcriptional network that is involved in the control of target genes associated with metabolic zonation as well as with lipid and drug metabolism
Gli2 protein expression is downregulated during neural tube patterning, regulating Shh (show SHH ELISA Kits) signaling. Shh (show SHH ELISA Kits)-induced upregulation of Gli2 transcription prevents Gli (show GLI1 ELISA Kits) activity levels from adapting in a different cell type.
GLI2 binds to the IL-6Ralpha (show IL6R ELISA Kits) promoter and regulates its activity as well as the expression of this receptor.
The results uncover that both Shh (show SHH ELISA Kits)/Gli2 and Shh (show SHH ELISA Kits)/Gli3 (show GLI3 ELISA Kits) signals are required for proper development of murine placentas and are possibly essential for pregnant maintenance.
While darinaparsin ameliorated fibrosis in WT and Gli1 (show GLI1 ELISA Kits)-KO mice, it was not effective in conditional Gli2-KO mice, supporting GLI2 as a direct darinaparsin target.
The ciliary localization of Gli2 is crucial for cilium-dependent activation of Hedgehog (show SHH ELISA Kits) signaling.
Systematic analysis in ESCs (show NR2E3 ELISA Kits) reveals that distinct regions of Gli2 regulate its nuclear and ciliary localization.
This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B.
GLI-Kruppel family member GLI2
, glioma-associated oncogene family zinc finger 2
, oncogene GLI2
, tax helper protein 1
, tax helper protein 2
, tax-responsive element-2 holding protein
, tax-responsive element-25-bp sequence binding protein
, zinc finger protein GLI2
, Zn finger transcription factor
, zinc finger protein GLI3
, Tax helper protein