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GLI2 is a dosage-sensitive gene that may be responsible for the agenesis of corpus callosum observed in the proband.
This inhibitory effect on cell growth was partially rescued by exogenous KRT17 (show KRT17 ELISA Kits) expression. In the KRT17 (show KRT17 ELISA Kits)-positive regions in OSCCs, GLI-1 (show GLI1 ELISA Kits) or GLI-2 was frequently detected, and the number of cells with cleaved caspase-3 (show CASP3 ELISA Kits) positive was decreased. CONCLUSIONS: KRT17 (show KRT17 ELISA Kits) promotes tumor cell growth, at least partially, through its anti-apoptotic effect as a result of the KRT17 (show KRT17 ELISA Kits) overexpression by GLIs in OSCC
Data suggest that Nrp1 (neuropilin-1 (show NRP1 ELISA Kits)) regulates Hedgehog (show SHH ELISA Kits) signaling specifically at the level of activation of GLI2 transcriptional activator function; Nrp1 (show NELL1 ELISA Kits) localization to primary cilium does not correlate with Hedgehog (show SHH ELISA Kits) signal promotion. These studies were conducted in various cell types.
studies identify a novel molecular mechanism of regulation of CD40L (show CD40LG ELISA Kits) by the transcription factor GLI2 in the tumor microenvironment downstream of CCR3 (show CCR3 ELISA Kits) signaling
the data suggest that CCRK (show CDK20 ELISA Kits) positively regulates the kinetics by which ciliary proteins such as Smoothened and Gli2 are imported into the cilium, and that the efficiency of ciliary recruitment allows for potent responses to Hedgehog (show SHH ELISA Kits) signaling over long time periods.
GLI2 is a regulator of beta-catenin (show CTNNB1 ELISA Kits) and provides insights into its role in tumorigenesis.
bioinformatics analysis and luciferase reporter assay predicted the direct binding to miR (show MLXIP ELISA Kits)-125b-5p, which has been reported to function as a tumor suppressor in osteosarcoma. Furthermore, functional experiments validated that cir (show KCNJ5 ELISA Kits)-GLI2 exerted the tumor-promoting effects on osteosarcoma cells via negatively targeting miR (show MLXIP ELISA Kits)-125b-5p.
GANT61, which is a targeted inhibitor of Gli1 (show GLI1 ELISA Kits) and Gli2, decreased cell viability and promoted cell apoptosis. Thus, TGF-b1 induced EMT (show ITK ELISA Kits) in neuroblastoma (show ARHGEF16 ELISA Kits) cells to increase their migration. Specifically, EMT (show ITK ELISA Kits) induced by TGF-b1 in neuroblastoma (show ARHGEF16 ELISA Kits) cells did not depend on the Smad (show SMAD1 ELISA Kits) signaling pathway, and the transcription factor Gli (show GLI1 ELISA Kits) participated in TGF-b1-induced EMT (show ITK ELISA Kits) independent of Smad (show SMAD1 ELISA Kits) signaling.
These results demonstrate that miR (show MLXIP ELISA Kits)-124 is an important downstream target gene of Hh signaling, and the Gli2/miR (show MLXIP ELISA Kits)-124/AURKA (show AURKA ELISA Kits) axis is essential for the proliferation and growth of human glioma cells.
in trophoblasts, GLI2 not only directly bound to the promoter region of gene hsd11b2 (show HSD11B2 ELISA Kits) to transactivate hsd11b2 (show HSD11B2 ELISA Kits) but also formed a heterodimer with RNA polymerase II, resulting in up-regulation of hsd11b2 (show HSD11B2 ELISA Kits) gene transcription
Data indicate that the expression levels of transcription factors Gli1 (show GLI1 ELISA Kits) and Gli2 in muscle were the lowest of the 13 tissues.
The 12 SNPs of GLI2 encompassing exon 4 to exon 8 showed strong association with in the anorectal atresia in pigs.
Gli2 and Gli3 (show GLI3 ELISA Kits) are dephosphorylated and activated in cilia and that impaired Gli2 and Gli3 (show GLI3 ELISA Kits) processing in Ta3 (show HSP90B1 ELISA Kits) mutant is at least in part due to a decrease in Gli2 and Gli3 (show GLI3 ELISA Kits) phosphorylation.
Sufu (show SUFUH ELISA Kits) is upregulated in active Shh (show SHH ELISA Kits) responding tissues and accompanies Gli (show GLI1 ELISA Kits) activators translocating into and Gli (show GLI1 ELISA Kits) repressors out of the nucleus.
Gli2+/-;Gli3Delta699/+ mice can serve as a genetic mouse model for common DSD (show FADS1 ELISA Kits).
Despite increased production of full-length GLI2 and GLI3 (show GLI3 ELISA Kits) isoforms, previously identified GLI (show GLI1 ELISA Kits) targets important for mandibular and glossal development (Foxf1 (show FOXF1 ELISA Kits), Foxf2 (show FOXF2 ELISA Kits), Foxd1 (show FOXD1 ELISA Kits) and Foxd2 (show FOXD2 ELISA Kits)) were transcriptionally downregulated in Kif3a (show KIF3A ELISA Kits)(f/f);Wnt1 (show WNT1 ELISA Kits)-Cre embryos.
Gli1 and Gli2 exhibited different functions in the regulation of p63 expression or proliferation of p63(+) cells in Kras-AR driven tumors.
the GLI2 protein level could serve as a feasible marker of ligand-dependent hedgehog (show SHH ELISA Kits) activation in pancreatic neoplasms.
Study suggested that loss of Gli2 mRNA mediated the anterior-restricted defect in conditional Dicer (show DICER1 ELISA Kits) knockdown mice and showed that miR (show MLXIP ELISA Kits)-106b positively regulated Gli2 mRNA expression
Sufu (show SUFUH ELISA Kits) deletion early in embryogenesis resulted in unstable Gli2 and Gli3 (show GLI3 ELISA Kits) activity, leading to the ectopic activation of Shh (show SHH ELISA Kits) signaling.
the three GLI (show GLI1 ELISA Kits) factors(GLI1 (show GLI1 ELISA Kits), GLI2, and GLI3 (show GLI3 ELISA Kits)) in mature hepatocytes form an interactive transcriptional network that is involved in the control of target genes associated with metabolic zonation as well as with lipid and drug metabolism
This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B.
GLI-Kruppel family member GLI2
, glioma-associated oncogene family zinc finger 2
, oncogene GLI2
, tax helper protein 1
, tax helper protein 2
, tax-responsive element-2 holding protein
, tax-responsive element-25-bp sequence binding protein
, zinc finger protein GLI2
, Zn finger transcription factor
, zinc finger protein GLI3
, Tax helper protein