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Browse our GLI3 Proteins (GLI3)

Full name:
GLI Family Zinc Finger 3 Proteins (GLI3)
On are 5 GLI Family Zinc Finger 3 (GLI3) Proteins from 3 different suppliers available. Additionally we are shipping GLI3 Antibodies (84) and GLI3 Kits (1) and many more products for this protein. A total of 92 GLI3 products are currently listed.
ACLS, add, AI854843, AU023367, Bph, GCPS, GLI3, GLI3-190, GLI3FL, im:7142603, PAP-A, PAPA, PAPA1, PAPB, Pdn, PHS, PPDIV, xgli3, Xt
list all proteins Gene Name GeneID UniProt
GLI3 2737 P10071
Rat GLI3 GLI3 140588  
GLI3 14634 Q61602

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GLI3 Proteins (GLI3) by Origin

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Human GLI Family Zinc Finger 3 (GLI3) interaction partners

  1. Gli3 and Teashirt3 (show ZNF537 Proteins) might play an important role in the normal development of the ureter.

  2. a novel GLI3 mutation c.714T>A (p.Y238*) was identified in a Chinese family with pre-axial polydactyly. Our results broadened the phenotypic spectrum of GLI3 mutations and demonstrated the feasibility of WES in clinical application of molecular diagnosis.

  3. we describe an ~5 kb deletion within the SHH (show SHH Proteins) repressor GLI3 in two patients with bilateral tibial hemimelia. This deletion results in a truncated GLI3 protein that lacks a DNA-binding domain and cannot repress hedgehog (show SHH Proteins) signaling.

  4. 2 independent cases of GLI3 morphopathies presented: one is a familial case of Greig Cephalopolysyndactyly Syndrome and the other a non-syndromic case of post-axial polydactyly, both are caused due to a truncation mutation at C-terminal of GLI3

  5. Gene silencing of GLI3 using RNA inference stimulated the growth of human Sertoli cells. miR (show MLXIP Proteins)-133b promoted the proliferation of human Sertoli cells by targeting GLI3.

  6. We report on a patient with GCPS caused by a novel GLI3 mutation.

  7. Identify mutations tha (show SUFUH Proteins)t in (show GLI1 Proteins)crease (show SOX10 Proteins) GLI activity in patients with Hirschsprung disease.

  8. To date, at least ten loci and four non-syndromic polydactyly-causing genes, including the GLI3 gene, the ZNF141 gene, the MIPOL1 (show MIPOL1 Proteins) gene and the PITX1 (show PITX1 Proteins) gene, have been identified. (Review)

  9. from ESCs (show NR2E3 Proteins) and induced pluripotent stem cells. SIGNIFICANCE STATEMENT: Our study presents a rapid and efficient protocol to generate human motoneurons from embryonic and induced pluripotent stem cells.

  10. High expression of GLI1 (show GLI1 Proteins) mRNA was associated with advanced lung adenocarcinoma.

Mouse (Murine) GLI Family Zinc Finger 3 (GLI3) interaction partners

  1. T-box3 interacts with Kif7 and is required for normal stoichiometry and function of a Kif7/Sufu (show SUFUH Proteins) complex that regulates Gli3 stability and processing.

  2. In Six2 (show SIX2 Proteins)-positive nephrogenic progenitors, GLI3 repressor decreased progenitor cell proliferation reducing the number of nephrogenic precursor structures in the Pallister-Hall syndrome mouse model.

  3. miR (show MLXIP Proteins)-378a-3p suppresses activation of hepatic stellate cells by targeting Gli3 and its expression.

  4. NANOG (show NANOG Proteins) binds to GLI1 (show GLI1 Proteins) and GLI3 proteins and represses Hedgehog (show SHH Proteins)-mediated transcription.

  5. Sufu (show SUFUH Proteins) deletion early in embryogenesis resulted in unstable Gli2 and Gli3 activity, leading to the ectopic activation of Shh (show SHH Proteins) signaling.

  6. Gli3 affects LOT positioning and target area innervation through controlling the development of the piriform cortex.

  7. These data demonstrate that GLI3 processing is a major outcome of primary cilia function in dorsal telencephalon morphogenesis.

  8. the three GLI (show GLI1 Proteins) factors(GLI1 (show GLI1 Proteins), GLI2, and GLI3) in mature hepatocytes form an interactive transcriptional network that is involved in the control of target genes associated with metabolic zonation as well as with lipid and drug metabolism

  9. Disruption of the SUFU (show SUFUH Proteins)-GLI (show GLI1 Proteins)-SOX10 (show SOX10 Proteins) regulatory loop disrupts migration of neural crest cells and development of the enteric nervous system in mice.

  10. The results uncover that both Shh (show SHH Proteins)/Gli2 and Shh (show SHH Proteins)/Gli3 signals are required for proper development of murine placentas and are possibly essential for pregnant maintenance.

Zebrafish GLI Family Zinc Finger 3 (GLI3) interaction partners

  1. Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog (show SHH Proteins) signaling. In the eye, Gli3 is also required for proper ath5 (show ATOH7 Proteins) expression and the differentiation of retinal ganglion cells.

Cow (Bovine) GLI Family Zinc Finger 3 (GLI3) interaction partners

  1. The results provided evidence that polymorphisms in the GLI3 gene are associated with growth traits, and may be used for marker-assisted selection in beef cattle breeding program.

GLI3 Protein Profile

Protein Summary

This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B.

Alternative names and synonyms associated with GLI3

  • GLI family zinc finger 3 (GLI3)
  • GLI-Kruppel family member GLI3 (LOC100355047)
  • GLI family zinc finger 3 (Gli3)
  • GLI family zinc finger 3 (gli3)
  • GLI-Kruppel family member GLI3 (Gli3)
  • GLI-Kruppel family member GLI3 (gli3)
  • transcriptional activator GLI3-like (LOC785371)
  • ACLS protein
  • add protein
  • AI854843 protein
  • AU023367 protein
  • Bph protein
  • GCPS protein
  • GLI3 protein
  • GLI3-190 protein
  • GLI3FL protein
  • im:7142603 protein
  • PAP-A protein
  • PAPA protein
  • PAPA1 protein
  • PAPB protein
  • Pdn protein
  • PHS protein
  • PPDIV protein
  • xgli3 protein
  • Xt protein

Protein level used designations for GLI3

GLI-Kruppel family member GLI3 , glioma-associated oncogene family zinc finger 3 , oncogene GLI3 , transcriptional activator GLI3 , zinc finger protein GLI3 , GLI-Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome) , GLI3 full length protein , neural specific DNA binding protein , neural-specific DNA-binding protein xGLI3 , xGLI-3 , GLI-Kruppel family member 3 , GLI3 form of 190 kDa , anterior digit pattern deformity , brachyphalangy , extra toes , polydactyly Nagoya , zinc finger transcription factor Gli3 , GLI family zinc finger 3

100064098 Equus caballus
100355047 Oryctolagus cuniculus
2737 Homo sapiens
420769 Gallus gallus
483244 Canis lupus familiaris
140588 Rattus norvegicus
397837 Xenopus laevis
463369 Pan troglodytes
14634 Mus musculus
403042 Danio rerio
785371 Bos taurus
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