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Hhat plays a critical role in ER positive, HER2 (show ERBB2 Proteins) amplified, and hormone resistant breast cancer proliferation.
Data suggest that substrate specificity of hedgehog acyltransferase (HHAT) in palmitoylation reaction extends to oligopeptide fragments of Sonic hedgehog protein (SHH (show SHH Proteins)).
three distinct members [porcupine (PORCN (show PORCN Proteins)), hedgehog (show SHH Proteins) (Hh) acyltransferase (HHAT) and ghrelin O-acyltransferase (GOAT)] have been shown to acylate specific proteins or peptides.
analysis of hedgehog acyltransferase membrane topology
rs7527939 is the strongest indicator of susceptibility to schizophrenia in the Bulgarian population within the HHAT locus.
SKN is necessary for the proliferation of the non-small cell lung carcinoma cells
These findings define residues and regions within Shh (show SHH Proteins) that are necessary for its recognition as a substrate for Hhat-mediated palmitoylation.
SKI-1/S1P (show MBTPS1 Proteins) activity is thus essential for hepatitis C virus production and its inhibition should be considered for antiviral drug development.
Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog (show SHH Proteins) signaling, resulting in severe acrania-holoprosencephaly-agnathia craniofacial defects.
Skinny hedgehog' (SKI1) encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of 'hedgehog' (see MIM 600725).
protein-cysteine N-palmitoyltransferase HHAT
, hedgehog acyltransferase
, protein-cysteine N-palmitoyltransferase HHAT-like
, melanoma antigen recognized by T cells 2
, melanoma antigen recognized by T-cells 2
, skinny hedgehog protein 1
, skinny hedgehog protein