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this study demonstrated an essential role of Ift27 in mediating hedgehog (show SHH Proteins) signaling during follicular keratinocyte proliferation and differentiation but not the differentiation program of the interfollicular epidermis.
IFT27 prevents aggregation of nucleotide-free ARL6 in solution
Lztfl1 (show LZTFL1 Proteins) accumulate to high levels in Ift27 mutant cilia.
Study coupled human genetics with functional validation in zebrafish and identified IFT27 as a novel BBS (show BBS2 Proteins) gene (BBS19).
This gene encodes a GTP-binding protein that is a core component of the intraflagellar transport complex B. Characterization of the similar Chlamydomonas protein indicates a function in cell cycle control. Alternative splicing of this gene results in multiple transcript variants.
RAB, member of RAS oncogene family-like 4
, intraflagellar transport 27 homolog
, intraflagellar transport protein 27 homolog
, rab-like protein 4
, putative GTP-binding protein RAY-like