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These results suggest that CED-4 forms a complex with ced-3 mRNA and delivers it to ribosomes for translation.
C14ORF179 encoding IFT43 is mutated in Sensenbrenner syndrome.
This gene encodes a subunit of the intraflagellar transport complex A (IFT-A). IFT-A is a multiprotein complex that plays an important role in cilia assembly and maintenance by mediating retrograde ciliary transport. Mutations in this gene are a cause of cranioectodermal dysplasia-3 (CED3), also known as Sensenbrenner syndrome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
intraflagellar transport protein 43 homolog
, IFT complex A subunit