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suggest that epigenetic inhibitors suppress the abnormal proliferation of lung adenocarcinoma cells highly expressing claudin-2
Data show that alterations in myosin light chain kinase (show MYLK ELISA Kits) activity, claudin-15 (show CLDN15 ELISA Kits) and claudin-2 expression are associated with gluten-induced symptomatology and intestinal permeability changes in diarrhea-predominant irritable bowel syndrome (IBS-D).
hypotonic stress induces dephosphorylation, clathrin-dependent endocytosis, and degradation of claudin-1 (show CLDN7 ELISA Kits) and -2 in lysosomes, resulting in disruption of the TJ barrier in renal tubular epithelial cells.
The claudin-2 expression increased in tumor necrosis factor alpha (TNF-alpha (show TNF ELISA Kits)) Treated Caco-2 cell monolayers.
We conclude that Claudin-2 expression is significantly associated with bile acid receptors VDR (show CYP27B1 ELISA Kits) and TGR5 (show GPBAR1 ELISA Kits) expression. Our studies identify a novel role of a tight junction protein (show OCLN ELISA Kits) in the development and progression of esophageal mucosal metaplasia, dysplasia and carcinoma.
The authors conclude that claudin-2 forms gated paracellular channels.
Genetic variants in CLDN2 and MORC4 (show MORC4 ELISA Kits) genes were associated with chronic pancreatitis in Indian patients.
The current study reveals an important and novel mechanism for VDR (show CYP27B1 ELISA Kits) by regulation of epithelial barriers.
Quercetin decreases claudin-2 expression mediated by up-regulation of miR-16 (show GDE1 ELISA Kits) expression and instability of claudin-2 mRNA in lung adenocarcinoma cells.
Pan-inhibition of SFK signaling pathways elevated Claudin-2 expression levels in breast cancer cells. Loss of Yes or Fyn (show FYN ELISA Kits) induces Claudin-2 expression; whereas, diminished Lyn (show LYN ELISA Kits) levels impairs Claudin-2 expression in breast cancer cells.
findings reveal a critical albeit complex role of claudin-2 in intestinal homeostasis by regulating epithelial permeability, inflammation and proliferation
Based on studies of Cldn2(-/-) mice, claudin 2 regulates paracellular ion and water flow required for proper regulation of bile composition and flow.
IL-6 (show IL6 ELISA Kits) modulation of intestinal TJ permeability was regulated by JNK (show MAPK8 ELISA Kits) activation of AP-1 (show JUN ELISA Kits) and AP-1 (show JUN ELISA Kits) activation of claudin-2 gene
this study set out to map out all the pore-lining residues of claudin-2 by comprehensive cysteine-scanning mutagenesis of the entire first extracellular loop (ECL1).
The capacity of non-AQP1 (show AQP1 ELISA Kits)-dependent transcellular proximal fluid reabsorption (PFR) is sufficient to be maintained in AQP1 (show AQP1 ELISA Kits)- and claudin-2-doubly deficient knockout mice.
These results suggest that the ERK (show EPHB2 ELISA Kits) pathway positively regulates claudin-2 protein expression and claudin-2 is involved in lowering TER (show TECR ELISA Kits) in CMT93-II cells.
Claudin-2 assumes an important role in colorectal inflammation, and furthermore implicates the involvement of MLCK (show MYLK ELISA Kits) in colon inflammation.
cingulin (show CGN ELISA Kits) is dispensable for the structure and barrier function of tight junctions, and is embedded in signaling networks that control the expression of claudin-2.
Together these data are consistent with phosphorylation at S208 playing a major role in the retention of claudin-2 at the plasma membrane
This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.
, integral membrane protein claudin-2