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Data indiate a regulatory network in gastric cancer whereby claudin-4 expression is reduced by specific miRNAs, which are in turn bound by specific lncRNAs acting as competing endogenous RNAs (ceRNAs), resulting in increased claudin-4 expression.
This is the first study to show how TGF-beta (show TGFB1 ELISA Kits) regulates the expression of Claudin-4 through c-Jun (show JUN ELISA Kits) signaling and how this pathway contributes to the migratory and tumorigenic phenotype of lung tumor cells.
Claudin-4 functionally contributes to both ovarian tumor cell apoptosis resistance and migration and targeting extracellular loop interactions of claudin-4 may have therapeutic implications for reducing ovarian tumor burden.
Fluorescence-based flow cytometry and xenon magnetic resonance imaging (MRI (show C7ORF49 ELISA Kits)) indicate binding of the biosensor specifically to claudin 4 (Cldn4)-expressing cells.
Studies indicate that Grainyhead-like transcription factor 2 (show HNF1B ELISA Kits) (GRHL2 (show GRHL2 ELISA Kits)) controls the expression of E-cadherin (CDH1 (show CDH1 ELISA Kits)) required for adherens junctions and possibly regulates the expression of claudin-4 (CLDN4) in tight junctions.
Studies indicate claudin 1 (CLDN-1 (show CLDN1 ELISA Kits)) as a target for improving epidermal drug absorption and preventing HCV infection and of claudin 4 (CLDN-4) as a target for anticancer therapeutics.
Mislocalization claudin-3 (show CLDN3 ELISA Kits) to nucleus in colon cancer and mislocalization claudin-4 to nucleus in adenomas of the colon were detected for the first time. The potential reasons for the paradoxical expression are discussed and a review of the literature, related all the alleged mechanisms of this mislocalization is provided.
Reg (show EXTL3 ELISA Kits) I may play a role in the maintenance of mucosal barrier function by inducing tight junction proteins such as claudins 3 and 4.
claudin-4 may represent different mechanisms of lymphatic vessel invasion with both biomarkers is related to poor prognosis
These results suggested that increase of Cldn4-expression may be involved in early molecular events during carcinogenesis of adenocarcinoma, whereas increase of Cldn7 (show CLDN7 ELISA Kits)-expression may be associated with tumor invasion or progression.
Reg (show KCNH2 ELISA Kits) I may play a role in the maintenance of mucosal barrier function by inducing tight junction proteins such as claudins 3 and 4.
a Grhl2 (show GRHL2 ELISA Kits)/Ovol2 network controls Cldn4 and Rab25 (show RAB25 ELISA Kits) expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia
Data show that claudin-4 and claudin-7 (show CLDN7 ELISA Kits) were observed in hepatocytes of severely damaged mouse and human livers.
The claudin-4-mediated chloride conductance can be regulated endogenously by a protease-channel-activating protease 1 (cap1 (show PRSS8 ELISA Kits)).
Claudin 4 has little effect on normal lung physiology but may function to protect against acute lung injury in mice.
The results suggest that progressive hydronephrosis in Cldn4(-/-) mice arises from urinary tract obstruction due to urothelial hyperplasia, and that Cld4 plays an important role in maintaining the homeostatic integrity of normal urothelium.
the results indicate that Grhl2 (show GRHL2 ELISA Kits) regulates epithelial morphogenesis through transcriptional up-regulation of Cldn3 (show CLDN3 ELISA Kits) and Cldn4, as well as of Rab25 (show RAB25 ELISA Kits), which increases the Cldn4 protein and its localization at TJs
Mechanism of Clostridium perfringens enterotoxin interaction with claudin-3 (show CLDN3 ELISA Kits)/-4 protein suggests structural modifications of the toxin to target specific claudins
Claudin-3 (show CLDN3 ELISA Kits) in the apical-most regions maintains the impermeable tight junctions during lactation, and claudin-4 contributes
Claudin-4 overexpression is associated with epigenetic derepression in gastric carcinoma.
Tumor necrosis factor-alpha (show TNF ELISA Kits) increases claudin-1 (show CLDN1 ELISA Kits), 4, and 7 expression in renal tubular cells, altering permeability and transepithelial electrical resistance.
Claudin-4 expression shows age-dependent change in cellular localization on pig jejunal villous epithelial cells
These findings indicate that claudin-4 and -7 may play a role in the gingiva junctional epithelium even in the absence of tight junctions.
This gene encodes an integral membrane protein, which belongs to the claudin family. The protein is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.
, Clostridium perfringens enterotoxin receptor 1
, Williams-Beuren syndrome chromosomal region 8 protein
, clostridium perfringens enterotoxin receptor
, tight junction-associated protein
, claudin 4
, uncharacterized protein LOC73934