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Mouse (Murine) CLDN5 ELISA Kit for Sandwich ELISA - ABIN831364
Holland, Searcy, Salvadores, Scullion, Chen, Lawson, Scott, Bastin, Ihara, Kalaria, Wood, Smith, Wardlaw, Horsburgh: Gliovascular disruption and cognitive deficits in a mouse model with features of small vessel disease. in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2015
In conclusion, our present study indicated that miR (show MYLIP ELISA Kits)-34c regulated the permeability of BTB via MAZ-mediated expression changes of ZO-1 (show TJP1 ELISA Kits), occludin (show OCLN ELISA Kits), and claudin-5.
The results of light- and electron-microscopic observations suggested that cldn5a and 5b are required for Xenopus heart tube formation through epithelialization of the precardiac mesoderm.
Downregulation of cldn5a in zebrafish showed a failure in organ laterality that resulted from malformed Kupffer's vesicle
identify Claudin5a as a core component of an early cerebral-ventricular barrier system that is required for ventricular lumen expansion in the zebrafish embryonic brain before the establishment of the embryonic blood-brain barrier.
Claudin-5 single-nucleotide polymorphism (SNP) rs885985 has two major alleles, G and A, which encode for glutamine (Q) or a stop signal, respectively, resulting in distinct overlapping open readings.
Data show that the charge of Lys65 in claudin 1 (Cldn1 (show CLDN1 ELISA Kits)) and Glu158 in claudin 3 (Cldn3 (show CLDN3 ELISA Kits)), and of Gln57 in claudin 5 (Cldn5) are necessary for tight junction (TJ) strand formation.
suggest that the reduction of CLDN5, 7, and 18 expression loses the suppressive ability of interaction between PDK1 (show PDK1 ELISA Kits) and Akt (show AKT1 ELISA Kits) and causes sustained phosphorylation of Akt (show AKT1 ELISA Kits), resulting in the disordered proliferation in lung squamous carcinoma cells
The levels of ESM1 (show ESM1 ELISA Kits), CLDN5, IL-1beta (show IL1B ELISA Kits), IL-6 (show IL6 ELISA Kits), and TNF-alpha (show TNF ELISA Kits) were significantly higher in the migraine attack group than in the control group
analysis of the membrane driven cis (show CISH ELISA Kits) interactions of claudin-5 proteins in the formation of the blood brain barrier tight junctions
the expression of claudin-5 and claudin-9 (show CLDN9 ELISA Kits) was down-regulated while the expression of claudin-8 (show CLDN8 ELISA Kits) was up-regulated in cervical carcinoma tissues compared with adjacent non-neoplastic tissues.
Plasma CLDN5 levels decreased in patients with stable asthma compared with those in control subjects, suggesting that asthma therapy can decrease plasma CLDN5 levels
These data support that loss of claudin-5 in cardiomyocytes and endothelial cells is prevalent in human heart failure
the relationship between vWF (show VWF ELISA Kits) and claudin-5, which are indicators of endothelial cell dysfunction and tight junction activity, may be a predictor of disease activity in rheumatoid arthritis.
The findings suggest that down regulated CLDN1 (show CLDN1 ELISA Kits) and CLDN5 genes have potential relevance in relation to the progression of glioblastoma multiforme.
This study demonstrated that the claudin-5(+) leukocytes in the central nervous system during neuroinflammation: a novel role for endothelial-derived (show MED28 ELISA Kits) extracellular vesicles.
claudin-3 (show CLDN3 ELISA Kits) and claudin-5 expression is increased by DHEAS (show SULT2A1 ELISA Kits) and tight junction formation is stimulated via a Gnalpha11-coupled receptor in Sertoli cells
Claudin 5 in a murine model of allergic asthma: Its implication and response to steroid treatment
while MMP-9 (show MMP9 ELISA Kits) is not essential for hypoxic-induced cerebral angiogenesis, it plays an important role in post-hypoxic vascular pruning by degrading laminin and claudin-5
Studied if circulating TGFbeta1 (show TGFB1 ELISA Kits) drives changes in tight junction protein (show OCLN ELISA Kits) expression and MMP9 (show MMP9 ELISA Kits) activity following acute liver failure; Mouse brain endothelial cells were treated with recombinant rTGFbeta1 and MMP9 (show MMP9 ELISA Kits) and claudin-5 expression was assessed.
In transgenic mice carrying mutated SOD1 (show SOD1 ELISA Kits) genes, a disrupted blood-spinal cord barrier as well as decreased levels of tight junction proteins ZO-1 (show TJP1 ELISA Kits), occludin (show OCLN ELISA Kits), and claudin-5 were detected.
The aim of the present study was to further characterize the estrogen-responsive elements of claudin-5 promoter.
Two independent pathways triggered by PI3K mediate early and late loss of paracellular claudin-5 expression.
Comparative modelling of intramolecular interfaces in the transmembrane region of claudins led to a complete Cldn5 model.
silencing of claudin-5 did significantly attenuate simvastatin-mediated endothelial cell barrier protection in response to thrombin (show F2 ELISA Kits)
Data show that IL-4 (show IL4 ELISA Kits) induces upregulation of the junction protein claudin-5 in endothelial cells (ECs) through activation of Jak (show JAK3 ELISA Kits)/STAT6 (show STAT6 ELISA Kits) and phosphorylation and translocation of FoxO1 (show FOXO1 ELISA Kits) from the nucleus to the cytoplasm.
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
, claudin 5
, claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)
, transmembrane protein deleted in VCFS
, transmembrane protein deleted in velocardiofacial syndrome
, brain endothelial cell clone 1 protein
, lung-specific membrane protein