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results indicated that LXRalpha (show NR1H3 Antibodies) plays a specific and important role in activation of TH by regulating D1, and that LXRalpha (show NR1H3 Antibodies) binds to and regulates the hDIO1 promoter, competing with TRbeta (show TXNRD2 Antibodies) on specific sequences within the promoter.
The DIO1 gene is related to the depression.
Functional variants within the DIO1 gene that affect triiodothyronine (T3) levels seem not to be associated with cognitive functions.
All these results indicate that the oxidative stress downregulates the conversion of T4 to T3 through DIO1 function in HepG2 cells.
Thyroid hormone (show PTH Antibodies) deiodinases D1, D2, and D3 are differentially expressed in endothelial cells following thyroid hormone (show PTH Antibodies) exposure.
The pattern of expression and role of triiodothyronine (T3) receptors and type I 5'-deiodinase (show DIO1 Antibodies) in breast carcinomas, benign breast diseases, lactational change, and normal breast epithelium.
[review] Deiodinase type 1 polymorphisms particularly show moderate-to-strong relationships with thyroid hormone (show PTH Antibodies) parameters, insulin (show INS Antibodies)-like growth factor (IGF)1 (show IGF1 Antibodies) protein production, and risk for depression.
a new mechanism of posttranscriptional regulation of DIO1 and show deregulation of DIO1 expression in pituitary adenoma, possibly resulting from disturbed expression of SF2/ASF (show SRSF1 Antibodies).
Dido1 induces the expression of Integrin alphaV, thereby promoting the attachment, migration, invasion and apoptosis resistance of melanoma cells.
Data show that CSE1L (show CSE1L Antibodies), DIDO1 and RBM39 (show RBM39 Antibodies) mRNA expression levels correlated with chromosome 20q DNA copy number status.
Embryonic stem cells mainly express DIDO3 and their differentiation after leukemia inhibitory factor (show LIF Antibodies) withdrawal requires DIDO1 expression. DIDO3 regulates DIDO1 expression.
Death inducer obliterator (Dido3)-dependent targeting of histone deacetylase 6 (HDAC6 (show HDAC6 Antibodies)) is a key determinant of cilium size in growth-arrested cells
Dido1 is able to regulate self-renewal of mouse embryonic stem cells.
Dido3 PHD (show PDC Antibodies) interacts with histone H3K4me3 and regulates expression of stemness genes in embryonic stem cells.
loss of Dido3 expression compromises differentiation of embryonic stem cells in vitro and of epiblast cells in vivo, resulting in early embryonic death at around day 8.5 of gestation
Dido3, the largest splice variant of the Dido gene, is a centrosome-associated protein (show BLOC1S2 Antibodies) whose disruption leads to supernumerary centrosomes, failure to maintain cellular mitotic arrest, and early degradation of the mitotic checkpoint (show BUB3 Antibodies) protein BubR1 (show BUB1B Antibodies).
results indicate that histone H3 (show HIST3H3 Antibodies) lysine 4 demethylation modulates DIDO3 localization in meiosis and suggest epigenetic regulation of the synaptonemal complex
The protein encoded by this gene is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). Alternative splicing results in multiple transcript variants encoding different isoforms. Some, but not all, isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Additional transcript variants have been described but are not supported by experimental evidence.
death inducer-obliterator 1
, death-inducer obliterator 1-like
, death-associated transcription factor 1
, death-inducer obliterator 1
, death inducer-obliterator-2
, death inducer-obliterator-3
, death associated transcription factor 1
, thyroxine deiodinase type I (selenoprotein)
, type 1 DI
, type I iodothyronine deiodinase
, type-I 5'-deiodinase