Browse our Islet Amyloid Polypeptide Proteins (IAPP)

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Islet Amyloid Polypeptide Proteins (IAPP)
On www.antibodies-online.com are 7 Islet Amyloid Polypeptide (IAPP) Proteins from 5 different suppliers available. Additionally we are shipping Islet Amyloid Polypeptide Antibodies (118) and Islet Amyloid Polypeptide Kits (78) and many more products for this protein. A total of 240 Islet Amyloid Polypeptide products are currently listed.
Synonyms:
Amylin, DAP, IAP, LOC100230121
list all proteins Gene Name GeneID UniProt
IAPP 3375 P10997
IAPP 24476 P12969
IAPP 15874 P12968

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Islet Amyloid Polypeptide Proteins (IAPP) by Origin

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More Proteins for Islet Amyloid Polypeptide Interaction Partners

Human Islet Amyloid Polypeptide (IAPP) interaction partners

  1. Data show that aluminum (Al3+) could inhibit islet amyloid polypeptide hIAPP(11-28) fibrillogenesis.

  2. The absence of BACE2 (show BACE2 Proteins) ameliorates glucose tolerance defects induced by IAPP overexpression in the beta-cell and promotes beta-cell survival.

  3. This study supports the elucidation of the structural basis of IAPP amyloid formation and highlights the extent of amyloid fibril polymorphism.

  4. Data suggest that a single GlcNAc residue at CTR (show CALCR Proteins) N130 (asparagine 130) is responsible for enhanced affinity of calcitonin (show CALCA Proteins) for CTR (show CALCR Proteins) ECD (show SHFM1 Proteins); the same appears to apply for enhanced affinity of amylin for RAMP2 (show RAMP2 Proteins)-CTR (show CALCR Proteins) ECD (show SHFM1 Proteins). [GlcNAc = N-acetylglucosamine; CTR (show CALCR Proteins) = calcitonin receptor (show CALCR Proteins); ECD (show SHFM1 Proteins) = extracellular domain; RAMP2 (show RAMP2 Proteins) = receptor (calcitonin) activity modifying protein 2 (show RAMP2 Proteins)].

  5. The kinetics of human amylin amyloid formation can be monitored by SYPRO-orange fluorescence and match the time course determined with thioflavin-T assays.

  6. effect of cholesterol on the amyloidogenicity of IAPP

  7. Chondroitin sulfate A has an intensive promotion effect on the fibrillation of human IAPP at the palmitoyloleoylphosphatidylcholine (POPC) membrane, which is larger than the total effect of Chondroitin sulfate A alone and POPC alone.

  8. C4BP (show C4BPA Proteins) protects beta-cells from IAPP cytotoxicity by modulating IAPP fibril formation extracellularly and also, after uptake by the cells, by enhancing cholesterol synthesis.

  9. beta-hairpin peptide inhibitor of IAPP aggregation that are stabilized in that conformation, or even forced to remain in the hairpin conformation by a backbone cyclization constraint, display superior activity as inhibitors.

  10. hA17-29 aggregate toxicity seems to be mediated by RAGE (show AGER Proteins) and p75-NGFR (show NGFR Proteins) receptors

Pig (Porcine) Islet Amyloid Polypeptide (IAPP) interaction partners

Mouse (Murine) Islet Amyloid Polypeptide (IAPP) interaction partners

  1. These data suggest participation by both soluble and fibrillar aggregates in IAPP-induced islet inflammation. IAPP-induced activation of TLR2 and secretion of IL-1 (show IL1A Proteins) may be important therapeutic targets to prevent amyloid-associated beta cell dysfunction.

  2. Hypothalamic amylin is transcriptionally regulated by leptin (show LEP Proteins), that it can act directly on ObRb (show LEPR Proteins) neurons in concert with leptin (show LEP Proteins), and that it regulates feeding.

  3. Matrix Metalloproteinase-9 (show MMP9 Proteins) Protects Islets from Amyloid-induced Toxicity.

  4. Data indicate that T-cell receptors that react to chromogranin A (ChgA (show CHGA Proteins)) and islet amyloid polypeptide precursor (IAPP) autoantigens were impaired when the thymic stromal cells lacked thymus-specific serine protease (TSSP (show PRSS16 Proteins)).

  5. Study the physiologic actions of IAPP on pancreatic beta cells, which secrete this peptide together with insulin (show INS Proteins) upon glucose stimulation. Explore the signaling pathways and mitogenic actions of IAPP on beta cells.

  6. deletion of the DeltaN isoforms of p63 (show CKAP4 Proteins) or p73 (show ARHGAP24 Proteins) leads to metabolic reprogramming and regression of p53 (show TP53 Proteins)-deficient tumours through upregulation of IAPP, the gene that encodes amylin, a 37-amino-acid peptide co-secreted with insulin (show INS Proteins) by the beta cells of the pancreas

  7. The stability, conformational dynamics and association force of different single-layer models of the full-length wild-type and glycine mutants of amylin, were investigated.

  8. studies have identified a novel TXNIP (show TXNIP Proteins)/miR (show MLXIP Proteins)-124a/FoxA2 (show FOXA2 Proteins)/IAPP signaling cascade linking the critical beta-cell signaling pathways of TXNIP (show TXNIP Proteins) and IAPP

  9. MMP-9 (show MMP9 Proteins) constitutes an endogenous islet protease that limits islet amyloid deposition and its toxic effects via degradation of hIAPP.

  10. Data suggest that amylin and leptin (show LEP Proteins) play additive roles in regulating energy homeostasis via activation of overlapping signalling pathways; mechanisms may be different in hypothalamus, muscle, and liver and in cases of endoplasmic reticulum stress.

Islet Amyloid Polypeptide (IAPP) Protein Profile

Protein Summary

Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.

Alternative names and synonyms associated with Islet Amyloid Polypeptide (IAPP)

  • islet amyloid polypeptide (LOC100230121)
  • islet amyloid polypeptide (IAPP)
  • islet amyloid polypeptide (Iapp)
  • islet amyloid polypeptide-like (LOC100520838)
  • Amylin protein
  • DAP protein
  • IAP protein
  • LOC100230121 protein

Protein level used designations for IAPP

islet amyloid polypeptide , Islet amyloid polypeptide (diabetes-associated peptide; amylin) , amylin , diabetes-associated peptide , insulinoma amyloid peptide , DAP , amyloid protein

GENE ID SPECIES
100230121 Taeniopygia guttata
3375 Homo sapiens
751513 Felis catus
100381251 Sus scrofa
24476 Rattus norvegicus
100135550 Cavia porcellus
15874 Mus musculus
100009489 Oryctolagus cuniculus
403909 Canis lupus familiaris
100138011 Bos taurus
101120402 Ovis aries
396362 Gallus gallus
101832022 Mesocricetus auratus
100520838 Sus scrofa
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