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Stanniocalcin 1 downregulation is responsible for sorafenib-induced cardiotoxicity through activated ROS (show ROS1 Proteins) generation.
the results suggest that the CaSR (show CASR Proteins) is critical for Ca(2 (show CA2 Proteins)+) homeostasis in larval zebrafish exposed to low environmental Ca(2 (show CA2 Proteins)+) levels, possibly owing to its modulation of stanniocalcin (show LOC100135946 Proteins) mRNA expression.
This study showed that stanniocalcin 1 (stc1)modulates cation levels in trpm7 (show TRPM7 Proteins) mutants and in the wild type; levels of cations are restored to normal in trpm7 (show TRPM7 Proteins) mutants when stc1 activity is blocked.
STC-1 negatively regulates epithelial Ca(2 (show CA2 Proteins)+) channel gene expression to reduce Ca(2 (show CA2 Proteins)+) uptake in zebrafish embryos
STC1 expression is significantly upregulated in human masticatory mucosa during wound healing
elevated STC-1 expression is associated with poor clinical outcome in triple-negative breast cancer (TNBC) patients, and STC-1 is directly involved in the invasiveness of TNBC cells
we demonstrated that aberrant STC1 expression is associated with poor prognosis and stimulates the invasiveness of triplenegative breast cancer cells
our findings strongly suggest that elevated expression of STC1 protein at the III-IV stage of lung adenocarcinoma promotes tumorigenesis of lung adenocarcinoma and positively associates with the cancer progression, which may be of potential value as tumor marker in clinical tracking lung adenocarcinoma progression.
Data suggest that stanniocalcin 1 and 2 (STC1, STC2 (show STC2 Proteins)) participate in inhibition of proteolytic activity of pregnancy-associated plasma protein-A (PAPP-A (show PAPPA Proteins)) during folliculogenesis.
STC1 gene expression at diagnosis might be a useful prognostic marker for clinical outcome and monitoring therapeutic response in patients with acute leukemia.
STC1 blunts bleomycin-induced rise in thrombin protein and activity, diminishes thrombin (show F2 Proteins)-induced signaling through PAR1 (show MARK2 Proteins) to ERK (show EPHB2 Proteins), and inhibits bleomycin-induced pneumonitis.
Data revealed the existence of a moderating effect between Klotho (show KL Proteins) and STC1, where Klotho (show KL Proteins) may inhibit thyroid tumor progression by inhibiting the tumor marker level of STC1.
High expression levels of stanniocalcin-1 is associated with Hepatocellular Carcinoma.
Results show that STC1 have an important role in the carbohydrate metabolism regulation, in particular gluconeogenesis from glutamine in the kidney, across the vertebrates.
The temporal and cell type-specific expression of STC1 makes this gene a unique marker for implantation in pigs.
The effect of STC1 on the steroidogenetic pathway in cultured granulosa cells is reported.
Over-expression of STC-1 up-regulated Bcl-2 (show BCL2 Proteins) protein expression and slightly down-regulated caspase-3 (show CASP3 Proteins) production in the damaged cells. Findings from this study suggest that STC-1 plays a protective role in intestinal cells through an antioxidant mechanism.
theca cell-derived big STC is targeted to the cholesterol/lipid storage droplets of luteal cells to regulate steroidogenesis.
once removed from their normal context within the ovary, luteal cells are capable of synthesizing and secreting big STC.
STC-1 in milk is increased following milk stasis
STC1 blunts bleomycin-induced rise in thrombin protein and activity, diminishes thrombin (show F2 Proteins)-induced signaling through PAR1 (show F2R Proteins) to ERK (show EPHB2 Proteins), and inhibits bleomycin-induced pneumonitis.
Stanniocalcin 1 is expressed in thyroid side population cells and thyroid cancer cells.
Mesenchymal stem cells correct inappropriate epithelial-mesenchyme relation in pulmonary fibrosis using Stc1.
Stanniocalcin-1 inhibits renal ischemia/reperfusion injury via an AMP-activated protein kinase (show PRKAA2 Proteins)-dependent pathway.
STC1 is an endogenous stress protein that may counteract LPS (show TLR4 Proteins)-induced lung injury by inhibiting the inflammatory cascade and inducing antioxidant and antiapoptotic mechanisms.
Remarkably, X-linked genes are not overexpressed in female Stc1(-/-) mice, revealing the existence of a mechanism(s) that can compensate for a persistent XCI deficiency to regulate X-linked gene expression.
Overexpression of stanniocalcin-1 inhibits reactive oxygen species and renal ischemia/reperfusion injury.
STC1 was not crucial for the development of ischemic tolerance triggered by hypoxic preconditioning, or for preserving blood-brain barrier integrity but may be involved in functional recovery after stroke.
the inner medullary STC-1 gene is differentially regulated in rat and mouse by arginine vasopressin (show AVP Proteins) and angiotensin II
Vascular endothelial growth factor-D (show Figf Proteins) stimulates endothelial cell VEGF-A (show VEGFA Proteins), stanniocalcin-1, and neuropilin-2 (show NRP2 Proteins) and has potent angiogenic effects.
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers.