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Browse our ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 Proteins (ABCC2)

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ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 Proteins (ABCC2)
On are 9 ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 (ABCC2) Proteins from 2 different suppliers available. Additionally we are shipping ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 Antibodies (54) and ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 Kits (1) and many more products for this protein. A total of 65 ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 products are currently listed.
Abc30, AI173996, Cmoat, cMRP, DJS, Mrp2
list all proteins Gene Name GeneID UniProt
ABCC2 1244 Q92887
ABCC2 12780 Q8VI47
Rat ABCC2 ABCC2 25303 Q63120

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ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 Proteins (ABCC2) by Origin

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More Proteins for ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 Interaction Partners

Human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 (ABCC2) interaction partners

  1. Four SNPs within the APOE (show APOE Proteins) cluster (rs7412, rs4420638), ABCC2 (rs2002042) and CELSR/SORT1 (show SORT1 Proteins)/PSRC1 (show PSRC1 Proteins) (rs646776), displayed a major impact on statin efficacy. The wGRS was significantly associated with lower LDL-C at age 75 and 80

  2. We analyzed 150 SNPs in eight key genes involved in vincristine pharmacokinetics and in 13 miRNAs that regulate them. We studied their correlation with neurotoxicity during induction phase in 152 ALL patients treated with LAL (show LIPA Proteins)/SHOP protocols. The strongest associations with neurotoxicity were observed for two SNPs in ABCC2.

  3. In the present review we focus on the role of MRP2 in the apical membrane of the enterocytes, as an important component of this intestinal barrier, as well as on its regulation and provide a detailed compilation of significant contributions demonstrating that MRP2 expression and function vary under relevant physiological and pathophysiological conditions

  4. ABCC2 polymorphisms were associated with hematological toxicity in non-small cell lung cancer patients.

  5. Meta-analysis. The ABCC2 c.-24C>T polymorphism increases the risk of resistance to antiepileptic drugs.

  6. we have investigated the role of ABCB1 (show ABCB1 Proteins) rs1045642 and rs2032582 and ABCC2 rs2273697 and rs717620 in antiepileptic drug-resistance. Our study suggests that the ABCC2 rs717620 polymorphism is associated with resistance to antiepileptic drugs in Chinese patients with epilepsy.

  7. A novel deletion in ABCC2 gene was identified in families with dual hereditary jaundice.

  8. Resveratrol-3-O-sulfate reduced in both MRP2-overexpressing MDCKII-UGT1A1 (show UGT1A1 Proteins) cells and Human UGT1A9 (show UGT1A9 Proteins)-overexpressing HeLa cells.

  9. A thalassemia patient has been found to be a carrier of UGT1A1 (show UGT1A1 Proteins) and ABCC2 polymorphisms explaining a possible reduction of desferasirox metabolism together with a reduction of biliary elimination by MRP2 and causing a serious adverse reaction.

  10. ABCC2 expression in PBMCs may be, in part, influenced by gender, and that at least two endogenous control genes should be utilized.

Mouse (Murine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 (ABCC2) interaction partners

  1. Biotinylation and streptavidin pull-down assays confirmed that CAL (show S100A11 Proteins) dramatically reduces the expression level of total and cell surface Mrp2 in Huh-7 cells. Our findings suggest that CAL (show S100A11 Proteins) interacts with Mrp2 and is a negative regulator of Mrp2 expression.

  2. Deficiency in Mrp2 lowers platinum excretion and increases susceptibility to kidney injury, which can be rescued by the human MRP2 ortholog.

  3. In Bcrp1;Mrp2;Mrp3(-/-), but not Bcrp1;Mdr1a/b;Mrp(-/-) mice.

  4. Cd or H(2)O(2) exposure increased the expression of key transport genes, Mrp1 (show ABCC1 Proteins) and Mrp2, in WT cells but not in metallothionein (show MT Proteins)-null cells.

  5. hepatic transporters Ntcp (show SLC10A1 Proteins) and Mrp2 are downregulated in rodent models of necrotizing enterocolitis

  6. Both Abcc2 and Abcc3 (show ABCC3 Proteins) significantly influenced the PK properties of MTX (show MTX1 Proteins).

  7. hyperosmotic cholestasis is triggered by a NADPH oxidase (show NOX1 Proteins)-driven reactive oxygen species formation that mediates Fyn (show FYN Proteins)-dependent retrieval of the Mrp2 and Bsep (show ABCB11 Proteins) from the canalicular membrane, which may involve an increased cortactin (show CTTN Proteins) phosphorylation.

  8. Strain- and sex-dependent circadian patterns in abcc2 expressions displayed robust relations with the chronotolerance of ileum mucosa for irinotecan

  9. In ABCC2-deficient mice impaired ABCC2 function is associated with a significant increase in erythromycin metabolism.

  10. Membrane vesicles prepared from human erythrocytes, which express the MRP2 have important implications for the Selenium-dependent and -independent disposition of Arasenic.

ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 (ABCC2) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine\; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.

Alternative names and synonyms associated with ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 (ABCC2)

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 2 (ABCC2)
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 2 (Abcc2)
  • ATP-binding cassette, subfamily C (CFTR/MRP), member 2 (Abcc2)
  • Abc30 protein
  • AI173996 protein
  • Cmoat protein
  • cMRP protein
  • DJS protein
  • Mrp2 protein

Protein level used designations for ABCC2

ATP-binding cassette sub-family C member 2 , canalicular multidrug resistance protein , canalicular multispecific organic anion transporter 1 , multidrug resistance-associated protein 2 , multidrug resistance protein 2 , ATP-binding cassette, sub-family C (CFTR/MRP), member 2 , calicular multispecific organic anion transporter , multidrug resistance associated protein 2

1244 Homo sapiens
12780 Mus musculus
25303 Rattus norvegicus
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