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We analyzed 150 SNPs in eight key genes involved in vincristine pharmacokinetics and in 13 miRNAs that regulate them. We studied their correlation with neurotoxicity during induction phase in 152 ALL patients treated with LAL (show LIPA Proteins)/SHOP protocols. The strongest associations with neurotoxicity were observed for two SNPs in ABCC2.
In the present review we focus on the role of MRP2 in the apical membrane of the enterocytes, as an important component of this intestinal barrier, as well as on its regulation and provide a detailed compilation of significant contributions demonstrating that MRP2 expression and function vary under relevant physiological and pathophysiological conditions
ABCC2 polymorphisms were associated with hematological toxicity in non-small cell lung cancer patients.
Meta-analysis. The ABCC2 c.-24C>T polymorphism increases the risk of resistance to antiepileptic drugs.
we have investigated the role of ABCB1 (show ABCB1 Proteins) rs1045642 and rs2032582 and ABCC2 rs2273697 and rs717620 in antiepileptic drug-resistance. Our study suggests that the ABCC2 rs717620 polymorphism is associated with resistance to antiepileptic drugs in Chinese patients with epilepsy.
A novel deletion in ABCC2 gene was identified in families with dual hereditary jaundice.
Resveratrol-3-O-sulfate reduced in both MRP2-overexpressing MDCKII-UGT1A1 (show UGT1A1 Proteins) cells and Human UGT1A9 (show UGT1A9 Proteins)-overexpressing HeLa cells.
A thalassemia patient has been found to be a carrier of UGT1A1 (show UGT1A1 Proteins) and ABCC2 polymorphisms explaining a possible reduction of desferasirox metabolism together with a reduction of biliary elimination by MRP2 and causing a serious adverse reaction.
ABCC2 expression in PBMCs may be, in part, influenced by gender, and that at least two endogenous control genes should be utilized.
Activation of liver PKCs during cholestasis leads to Ezrin (show EZR Proteins) Thr567 phosphorylation resulting in MRP2 internalization and degradation where ubiquitin ligase E3 GP78 (show AMFR Proteins) is involved.
Deficiency in Mrp2 lowers platinum excretion and increases susceptibility to kidney injury, which can be rescued by the human MRP2 ortholog.
In Bcrp1;Mrp2;Mrp3(-/-), but not Bcrp1;Mdr1a/b;Mrp(-/-) mice.
Cd or H(2)O(2) exposure increased the expression of key transport genes, Mrp1 (show ABCC1 Proteins) and Mrp2, in WT cells but not in metallothionein (show MT Proteins)-null cells.
hepatic transporters Ntcp (show SLC10A1 Proteins) and Mrp2 are downregulated in rodent models of necrotizing enterocolitis
Both Abcc2 and Abcc3 (show ABCC3 Proteins) significantly influenced the PK properties of MTX (show MTX1 Proteins).
hyperosmotic cholestasis is triggered by a NADPH oxidase (show NOX1 Proteins)-driven reactive oxygen species formation that mediates Fyn (show FYN Proteins)-dependent retrieval of the Mrp2 and Bsep (show ABCB11 Proteins) from the canalicular membrane, which may involve an increased cortactin (show CTTN Proteins) phosphorylation.
Strain- and sex-dependent circadian patterns in abcc2 expressions displayed robust relations with the chronotolerance of ileum mucosa for irinotecan
In ABCC2-deficient mice impaired ABCC2 function is associated with a significant increase in erythromycin metabolism.
Membrane vesicles prepared from human erythrocytes, which express the MRP2 have important implications for the Selenium-dependent and -independent disposition of Arasenic.
NHERF-1 (show SLC9A3R1 Proteins) binds to Mrp2, and plays a critical role in the canalicular expression of Mrp2 and its function as a determinant of glutathione-dependent, bile acid-independent bile flow
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine\; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.
ATP-binding cassette sub-family C member 2
, canalicular multidrug resistance protein
, canalicular multispecific organic anion transporter 1
, multidrug resistance-associated protein 2
, multidrug resistance protein 2
, ATP-binding cassette, sub-family C (CFTR/MRP), member 2
, calicular multispecific organic anion transporter
, multidrug resistance associated protein 2