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The effects of dietary energy on the metabolism of ghrelin (show GHRL ELISA Kits), leptin (show LEP ELISA Kits) and growth hormone secretagogue receptor in blood and tissues of steers are reported.
The coding regions of GHSR and SLC2A2 (show SLC2A2 ELISA Kits) were sequenced in 12 animals with extreme phenotypes for feed intake and gain; Sixteen SNPs were identified in SLC2A2 (show SLC2A2 ELISA Kits), and three were detected in GHSR.
provided conclusive evidence that the 19-TG allele of the 5'UTR (show UTS2R ELISA Kits) microsatellite of the bovine GHSR1a gene affects growth and carcass traits in Japanese Black cattle
We evaluated the haplotype variety and characterized the microsatellite ((TG)(n) , 5'-UTR (show UTS2R ELISA Kits)) and nucleotide polymorphisms of the bovine GHSR1a gene.
it showed that the antinociception of ghrelin (show GHRL ELISA Kits) was correlated with the GHS-R1alpha and d-opioid receptors. Finally, the antinociception induced by deltorphin II wasn't blocked by the co-injection (i.c.v.) of [D-Lys (show LYZ ELISA Kits)(3)]-GHRP-6, indicating that the GHS-R1a isn't on the backward position of delta opioid receptor.
our results showed for the first time that the downregulation of GHSR1a by shRNA technology inhibits the growth of colorectal cancer cell line and xenograft tumor through upregulation of PTEN at transcription as well as translation levels.
GHSR mutations are associated with Obesity.
Results indicate that neuronal GHS-R is a crucial regulator of energy metabolism and a key mediator of DIO. Neuronal Ghsr deletion protects against DIO by regulating energy expenditure, not by energy intake. These novel findings suggest that suppressing central ghrelin (show GHRL ELISA Kits) signaling may serve as a unique antiobesity strategy.
Results suggest that the minor allele of the rs2948694 in the GHSR gene was associated with increased smoking possibly reflects an association with alcohol use disorder and nicotine dependence.
GHS-R1b (show HOXB7 ELISA Kits) not only determines the efficacy of ghrelin (show GHRL ELISA Kits)-induced GHS-R1a-mediated signaling but also determines the ability of GHS-R1a to form oligomeric complexes with other receptors.
The data indicates that GHSR hypermethylation is a pan-cancer marker regardless of the tissue from which the tumor originates.
the single nucleotide polymorphism of GHSR might be weaker association with cancer risk, especially with breast cancer risk
Data (including data from knockout mice) suggest ghrelin (show GHRL ELISA Kits) produced in pancreatic islets regulates insulin (show INS ELISA Kits) secretion and thereby regulates blood glucose; ghrelin (show GHRL ELISA Kits) signaling via growth hormone secretagogue-receptor appears to be involved. [REVIEW]
This study suggests that the rs696217 and rs2075356 ghrelin (show GHRL ELISA Kits) gene (GHRL (show GHRL ELISA Kits)) polymorphisms may protect carriers against breast cancer, and the rs4684677 GHRL (show GHRL ELISA Kits) and rs572169 GHSR polymorphisms may increase the risk among carriers.[Meta-analysis]
Fasting upregulates Fpn1 (show SLC40A1 ELISA Kits) expression in spleen and peritoneal macrophages, probably via a ghrelin (show GHRL ELISA Kits)/GHSR1a/MAPK (show MAPK1 ELISA Kits) signaling pathway.
our results suggest that AgRP (show AGRP ELISA Kits) neurons are key site for GHS-R mediated thermogenesis, and demonstrate that GHS-R in AgRP (show AGRP ELISA Kits) neurons plays crucial roles in governing energy utilization and pathogenesis of DIO.
Growth hormone secretagogue receptor (GHSR) deficiency suppresses smooth muscle cell (SMCs) numbers in in the neointima.
Studies demonstrate that ghrelin (show GHRL ELISA Kits) signaling has an important role in macrophage polarization and adipose tissue inflammation during aging.
Study demonstrated that NMDAR (show GRIN1 ELISA Kits) functions are regulated by ghrelin (show GHRL ELISA Kits) in a GHSR1a-dependent manner: NMDAR (show GRIN1 ELISA Kits)-mediated synaptic currents are increased as a result of GluN1 (show GRIN1 ELISA Kits) subunit phosphorylation in the hippocampal pyramidal neurons and synapses
Ghsr mediates the beneficial effects of Caloric restriction on enhancing adult hippocampal neurogenesis and memory.
Data show that chronic caloric restriction (CR) alters hypothalamic agouti-related protein (Agrp (show AGRP ELISA Kits)) and neuropeptide Y (Npy (show NPY ELISA Kits)) gene expression similarly in Ghrelin (show GHRL ELISA Kits)+/+, Ghrelin (show GHRL ELISA Kits)-/-, ghrelin receptor Ghsr+/+, and Ghsr-/- mice.
The expression of ghrelin (show GHRL ELISA Kits) and GH secretagogue receptor 1a [GHSR1a] in cerebral arteries and the effects of ghrelin (show GHRL ELISA Kits) analogs on cerebrovascular function are reproted.[GHSR1a]
Thus, GHSR1a differentially inhibits CaV2 (show CAV2 ELISA Kits) channels by Gi/o or Gq protein pathways depending on its mode of activation.
The results of this study indicated that ghrelin receptor signaling is not required for flavor preferences conditioned by the oral or post-oral actions of sugar and fat.
GHSR-1a is present in prepubertal pig ovary; no influence of GH on GHSR-1a expression is found.
This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein\; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin\; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.
, growth hormone secretagogue receptor type 1
, growth hormone secretagogue receptor
, ghrelin/growth hormone secretagogue receptor
, growth hormone secretagogue receptor type 1A
, growth hormone secretagogue receptor, type 1A
, growth hormone secretagogue receptor type 1-like
, GH-releasing peptide receptor
, G-protein coupled receptor
, growth hormone secretagogue receptor type 1b