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Browse our HNF1 Homeobox B Proteins (HNF1B)

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HNF1 Homeobox B Proteins (HNF1B)
On are 8 HNF1 Homeobox B (HNF1B) Proteins from 5 different suppliers available. Additionally we are shipping HNF1 Homeobox B Antibodies (121) and HNF1 Homeobox B Kits (31) and many more products for this protein. A total of 169 HNF1 Homeobox B products are currently listed.
AI385728, AI987804, chunp6877, FJHN, HNF-1b, HNF-1Beta, hnf1-beta, hnf1b, Hnf1beta, HNF2, HPC11, LF-B3, lfb3, MODY5, mst, Tcf-2, Tcf2, vHNF-1, vHNF1
list all proteins Gene Name GeneID UniProt
HNF1B 6928 P35680
HNF1B 21410 P27889
HNF1B 25640 P23899

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HNF1 Homeobox B Proteins (HNF1B) by Origin

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More Proteins for HNF1 Homeobox B Interaction Partners

Human HNF1 Homeobox B (HNF1B) interaction partners

  1. importin-beta (show KPNB1 Proteins) is involved in the maintenance of the mitotic retention of HNF1beta, suggesting a functional link between the nuclear import system and the mitotic localization/translocation of bookmarking factors.

  2. rs11651755 in HNF1B was found to be associated with endometriosis in this case-control study.

  3. Because HNF1B-related disease is a heterozygous condition, calcineurin (show PPP3CA Proteins) inhibitors used to prevent rejection may induce reduced expression of the nonmutated allele of HNF1B leading to a superimposed defect of HNF-1beta transcriptional activity.

  4. HNF1B is a novel oncogene (show RAB1A Proteins) that can work cooperatively with ERBB2 (show ERBB2 Proteins).

  5. We confirmed the significance of the HNF1B and GATA4 (show GATA4 Proteins) hypermethylation with emphasis on the need of selecting the most relevant sites for analysis. We suggest selected CpGs to be further examined as a potential positive prognostic factor.

  6. The diffuse and strong HNF-1beta expression pattern can be used to diagnose ovarian clear cell carcinoma (OCCC) with high specificity.

  7. Studied the role of HNF1B abnormalities in the occurrence of cognitive defects, the frequency of ID was assessed according to the presence of HNF1B mutations or deletion in a large cohort of adult patients with HNF1B-MODY (show HNF4A Proteins).

  8. Expression of HNF-1-beta was detected in various extents in all types of lesions.

  9. Glutaminolysis is activated in ES2 (show DGCR14 Proteins) and OVCAR3, though ES2 (show DGCR14 Proteins) exclusively synthesizes amino acids and GSH. ES2 (show DGCR14 Proteins) cells are more resistant to carboplatin than OVCAR3 and the abrogation of GSH production by BSO sensitizes ES2 (show DGCR14 Proteins) to carboplatin. HNF1beta regulates the expression of GCLC (show GCLC Proteins), but not GCLM (show GCLM Proteins), and consequently GSH production in ES2 (show DGCR14 Proteins)

  10. HNF1B mutations are associated with Maturity onset diabetes of youth.

Xenopus laevis HNF1 Homeobox B (HNF1B) interaction partners

  1. Overexpression of two mutant HNF1B derivatives resulted in distinct phenotypes reflected by either a reduction or an enlargement of pronephros size.

  2. nephrogenic transcription factors (osr1 (show OSR1 Proteins), osr2, hnf1b, lhx1 (show LHX1 Proteins), pax8 (show PAX8 Proteins))play important role in nephrogenesis but have no pronephros induction potential upon overexpression; they activate transcription cascades reflecting activation by activin A (show INHBA Proteins), retinoic acid

  3. CHOP (GADD153 (show DDIT3 Proteins)) is an inhibitor of Wnt (show WNT2 Proteins)/TCF (show HNF4A Proteins) signals

Mouse (Murine) HNF1 Homeobox B (HNF1B) interaction partners

  1. These results demonstrated the crucial role of Hnf1b and Foxa3 (show FOXA3 Proteins) in hepatogenesis in vitro and provided a valuable tool for the efficient differentiation of HLCs (show HLCS Proteins) from ES cells.

  2. HNF-1beta Regulates MicroRNA-200 Expression through a Long Noncoding RNA

  3. TNFalpha (show TNF Proteins) regulates uromodulin (show UMOD Proteins) expression in a homeostatic setting, but the impact of TNFalpha (show TNF Proteins) on uromodulin (show UMOD Proteins) during kidney injury is superseded by other factors that could inhibit HNF1beta-mediated expression of uromodulin (show UMOD Proteins).

  4. Hypoxia induced early up-regulation of Hnf-1beta from 1 to 24 hours, independently of the hypoxia-inducible factor Hif-1alpha (show HIF1A Proteins).

  5. Zyxin (show ZYX Proteins) regulates migration of renal epithelial cells through activation of hepatocyte nuclear factor-1beta.

  6. HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch (show NOTCH1 Proteins) signalling components and Irx1 (show IRX1 Proteins)/2.

  7. identification of Hnf1b as a target of miR (show MLXIP Proteins)-802-dependent silencing; show that short hairpin RNA (shRNA)-mediated reduction of Hnf1b in liver causes glucose intolerance, impairs insulin (show INS Proteins) signalling and promotes hepatic gluconeogenesis

  8. Hnf1b and Pax2 (show PAX2 Proteins) operate to control kidney morphogenesis and ureter differentiation.

  9. Overexpression of HNF1beta resulted in accelerated cell proliferation with the protein level up-regulation of plasminogen (show PLG Proteins) and plasmin (show PLG Proteins), a converted active form of plasminogen (show PLG Proteins), which play a pivotal role in liver regeneration inducing hepatocyte proliferation.

  10. Data indicate that HNF1alpha (show HNF1A Proteins) is a more potent activator of AFM (show AFM Proteins) promoter than is HNF1beta.

Zebrafish HNF1 Homeobox B (HNF1B) interaction partners

  1. Data show that hnf1ba generates a permissive domain for Wnt (show WNT2 Proteins) signaling activity in the foregut endoderm

  2. Knockdown of pk1a led to decreased expression of vhnf1, a homeodomain gene previously shown to be involved in biliary development and in kidney cyst formation; forced expression of vhnf1 mRNA led to rescue of the pk1a morphant phenotype

  3. Data show that vhnf1 functions in two ways to subdivide the zebrafish caudal hindbrain domain (r4-r7) into individual rhombomeres.

  4. Zebrafish tcf2 gene, composed of 9 exons, was mapped to linkage group LG15.

  5. vhnf1 acts largely independently of val to repress the rhombomere 4 'hox (show MSH2 Proteins) code' posterior to the rhombomere 4-5 boundary

  6. Vhnf1 expression within the posterior neural tube (up to r5) promotes posterior and dorsal fates in the otic vesicle, at the expense of anterior and ventral fates.

  7. investigated the signaling pathways that regulate vhnf1 expression during pancreas development

  8. Data show that zebrafish mutants for Tcf2 fail to specify a single lumen in their gut (show GUSB Proteins) tube and instead develop multiple lumens, and show that Tcf2 controls single lumen formation by regulating claudin15 and Na+/K+-ATPase (show ATP1A1 Proteins) expression.

  9. vHNF1 plays crucial role at the earliest steps of liver induction: the acquisition of endoderm competence and the hepatic specification.

  10. It was concluded that hnf1b(hi2169) is hypomorphic to hnf1b(hi1843) and that, while hnf1b is required for r5/r6 gene expression in the hindbrain, r5/r6 gene expression can be experimentally induced independently of hnf1b anterior to the hindbrain.

HNF1 Homeobox B (HNF1B) Protein Profile

Protein Summary

This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with HNF1 Homeobox B (HNF1B)

  • HNF1 homeobox B (HNF1B)
  • hepatocyte nuclear factor 1-beta-like (LOC100355480)
  • HNF1 homeobox B (hnf1b)
  • HNF1 homeobox B (Hnf1b)
  • HNF1 homeobox Ba (hnf1ba)
  • transcription factor 2 (hnf1b)
  • AI385728 protein
  • AI987804 protein
  • chunp6877 protein
  • FJHN protein
  • HNF-1b protein
  • HNF-1Beta protein
  • hnf1-beta protein
  • hnf1b protein
  • Hnf1beta protein
  • HNF2 protein
  • HPC11 protein
  • LF-B3 protein
  • lfb3 protein
  • MODY5 protein
  • mst protein
  • Tcf-2 protein
  • Tcf2 protein
  • vHNF-1 protein
  • vHNF1 protein

Protein level used designations for HNF1 Homeobox B Proteins (HNF1B)

transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor , HNF1 homeobox B , HNF-1-beta , HNF1 beta A , hepatocyte nuclear factor 1-beta , homeoprotein LFB3 , transcription factor 2, hepatic , FPC-binding protein , FPCB , HNF-1B , TCF-2 , variant hepatic nuclear factor 1 , hepatocyte nuclear factor-1 beta , transcription factor 2 , Transcription factor 2 hepatic , Transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor , Transcription factor 2, hepatic , Transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor , hepatocyte nuclear factor 1 beta , HNF-1-beta-A , HNF-1B-2 , HNF-1B-A , HNF1 homeobox b , hepatocyte nuclear factor 1-beta-2 , hepatocyte nuclear factor 1-beta-A , hob , xlFB3

468227 Pan troglodytes
100057769 Equus caballus
100355480 Oryctolagus cuniculus
6928 Homo sapiens
398842 Xenopus laevis
427838 Gallus gallus
610402 Canis lupus familiaris
397002 Sus scrofa
21410 Mus musculus
25640 Rattus norvegicus
100734532 Cavia porcellus
503581 Bos taurus
792391 Danio rerio
380377 Xenopus laevis
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