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MRAP2b decreases the constitutive activity of the MC4R during fasting periods, driving the animal toward a positive energy balance.
MRAP2 proteins allow for developmental control of MC4R activity, with MRAP2a blocking its function and stimulating growth during larval development, whereas MRAP2b enhances responsiveness to alpha-MSH once the zebrafish begins feeding, thus increasing the capacity for regulated feeding and growth.
Gene polymorphism rs17782313 of the MC4R gene was associated with large artery atherosclerotic stroke susceptibility in smokers. Multifactor dimensionality reduction analysis revealed that the combination of MC4R variant (rs17782313), hypertension and smoking habit was significantly associated with increased risk of large artery atherosclerotic stroke in a Chinese Han population.
In a large all-adult and area-based population survey the effects of obesity-promoting minor-alleles of FTO (show FTO ELISA Kits) and MCR4, and interactions with life style factors are age- and gender-related
the C/X genotype of the MC4R gene seems to predispose postmenopausal women to developing some metabolic syndrome symptoms
we performed a candidate-gene association study in a young and sportive Italian population by testing the association of functional polymorphisms in ACE (show ACE ELISA Kits) (rs4646994), FTO (show FTO ELISA Kits) (rs9939609), MC4R (rs17782313) and PPARG (show PPARG ELISA Kits) (rs1801282) genes with body mass index (BMI) and waist-to-height ratio (WHtR).
The family-based association analysis showed that there was a significant association between rs12970134 and obesity. rs12970134 near MC4R was associated with appetite and beverage intake.
The rs12970134 of melanocortin 4 receptor melanocortin was found to be associated with body mass index only in children with physical activity<1h/d and sedentary behaviors >=2h/d.
Genetic clues to the mechanism by which MC4R, FTO, and NMB influences changes in BMI and obesity.
Results show regulation of melanocortin receptors MC2R (show MC2R ELISA Kits), MC3R (show MC3R ELISA Kits) and MC4R gene expressions in CD8 (show CD8A ELISA Kits)(+) cytotoxic T-lymphocytes and CD19 (show CD19 ELISA Kits)(+) B lymphocytes in rheumatoid arthritis (RA) treated with tumor necrosis factor-alpha (TNF-alpha (show TNF ELISA Kits)) inhibitor (show ZFP36 ELISA Kits) adalimumab.
BDNF (show BDNF ELISA Kits) rs2030323 is associated with 100 to 150 greater total caloric intake per allele, with additional contributions of MC4R and, in non-Hispanic white individuals, FTO (show FTO ELISA Kits).
The common variant rs17782313 near MC4R is associated with body mass index and measures of body fatness in children aged 2-9 years.
Confirmation of the impairment of GH-IGF-1 (show IGF1 ELISA Kits) release in hyperphagic MC4R KO mice suggests a role for insulin (show INS ELISA Kits) in regulating both the release of GH, but also in mediating growth during periods of physiologically suppressed GH-IGF-1 (show IGF1 ELISA Kits) levels
Loss of Mc4r expression is associated with non-alcoholic fatty liver disease.
results identify lipocalin 2 (show LCN2 ELISA Kits) as a bone-derived hormone with metabolic regulatory effects, which suppresses appetite in a MC4R-dependent manner, and show that the control of appetite is an endocrine function of bone
Atherosclerosis and Hypercholesterolemia in Mice Lacking Both the Melanocortin Type 4 Receptor and Low Density Lipoprotein Receptor (show LDLR ELISA Kits)
results indicate that the MC4R is not required for estrogen's effects on metabolic and reproductive functions
Mc4r receptor expression in the cuneiform nucleus is involved in modulation of opioidergic signaling.
Together, these results suggest that alpha-MSH alleviates Dex-induced damages to cultured osteoblasts through activating MC4R-SphK1 (show SPHK1 ELISA Kits) signaling.
Our findings support the hypothesis that MC4R signaling in the pedunculopontine tegmental nucleus may involve in the modulation of midbrain dopamine systems.
These results indicate that intact CNS MC4R signaling is necessary for leptin (show LEP ELISA Kits) to exert its chronic antidiabetic, anorexic, and cardiovascular actions.
Mc4r signaling has a protective role in minimizing glucose fluctuations due to circadian rhythms and environmental light cues, a previously undiscovered connection between circadian biology and glucose metabolism mediated through the melanocortin system.
evaluate the association of single nucleotide polymorphisms (SNPs) in MC4R with milk production traits in water buffalo. Based on the SNP data, seven haplotypes were constructed. Three SNPs H1 (AGT (show AGT ELISA Kits)), H2 (GAT), and H3 (GAC (show GLS ELISA Kits)) accounted for 93.0% of the total individuals. Statistical analysis indicated that the SNP g.1104C>T was significantly associated with milk yield, protein, and fat percentage.
The MC4R gene may thus be a candidate gene for carcass traits with MC4R single nucleotide polymorphisms being potentially valuable as genetic markers for economic traits in Hanwoo.
The aim was to estimate the frequency of the SNPs in the MC4R gene and to determine if individual genotypes were associated with several economic traits.
The results suggested that -129A>G and 1,069C>G single nucleotide polymorphism of the MC4R gene may be useful as a genetic marker for carcass and meat quality traits in Qinchuan cattle.
results are suggestive that adrenal glucocorticoid production could be regulated through melanocortin 4 receptor
Single nucleotide polymorphisms in 5'-untranslated region of MC4R gene, were detected.
These results indicate that genetic selection against boar taint is possible using MC4R as a marker.
These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.
Transcriptional profiling was used to identify genes and pathways that responded to intracerebroventricular injection of MC4R agonist [Nle(4), d-Phe(7)]-alpha-melanocyte stimulating hormone (show POMC ELISA Kits) in pigs homozygous for the missense mutation in the MC4R.
study did not find any significant associations for polymorphisms in insulin (show INS ELISA Kits)-like grwoth factor 2, GTP Binding Protein (show RND1 ELISA Kits) alpha Subunits, Gs and melanocortin receptor 4 genes with reproductive traits of Polish Landrace and Large White pigs
Linkage disequilibrium analysis among MC4R, LEP (show LEP ELISA Kits) and H-FABP (show FABP3 ELISA Kits) revealed that these genes were independent.
The c.1426G>A polymorphism affects daily gain, feed conversion ratio and ham (show ATF7IP ELISA Kits) weight in both breeds, lean cuts in the Italian Duroc and backfat thickness in the Italian Large White.
MC4R allelic variants had no effects on meat quality traits.
The effects of missense mutations of MC4R on carcass composition, growth traits and meat quality in 1191 gilts of five swine breeds are reported.
No effect of the MC4R trait nucleotides could be seen on muscle growth.
Results of associated analysis show that the polymorphism of MC4R gene was associated traits of back fat thickness (BF).
The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity.
melanocortin receptor 4
, melanocortin 4-receptor
, melanocortin 4 receptor
, melanocortin-4 receptor
, Melanocortin receptor 4