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Methyl CpG Binding Protein 2 ELISA Kits (MECP2)
On www.antibodies-online.com are 13 Methyl CpG Binding Protein 2 (MECP2) ELISA Kits from 6 different suppliers available. Additionally we are shipping Methyl CpG Binding Protein 2 Antibodies (233) and Methyl CpG Binding Protein 2 Proteins (13) and many more products for this protein. A total of 273 Methyl CpG Binding Protein 2 products are currently listed.
Synonyms:
1500041B07Rik, AUTSX3, BB130002, D630021H01Rik, Mbd5, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTT, WBP10, wu:fk96a04, zgc:111857
list all ELISA KIts Gene Name GeneID UniProt
MECP2 4204 P51608
MECP2 17257 Q9Z2D6
MECP2 29386 Q00566

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Methyl CpG Binding Protein 2 (MECP2) ELISA Kits by Reactivity

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More ELISA Kits for Methyl CpG Binding Protein 2 Interaction Partners

Mouse (Murine) Methyl CpG Binding Protein 2 (MECP2) interaction partners

  1. these findings demonstrate that increasing MeCP2 T158M protein expression is sufficient to mitigate Rett syndrome-like phenotypes and support the targeting of MeCP2 T158M expression or stability as an alternative therapeutic approach.

  2. Loss of Mecp2 is associated with Rett syndrome.

  3. Mice that lacked Mecp2 in macrophages displayed spontaneous obesity, which was linked to impaired function of brown adipose tissue (BAT (show BAAT ELISA Kits)). Specifically, mutagenesis of a BAT (show BAAT ELISA Kits)-resident Cx3Cr1 (show CX3CR1 ELISA Kits)+ macrophage subpopulation compromised homeostatic thermogenesis but not acute, cold-induced thermogenesis. This was associated with diminished sympathetic innervation and local titers of norepinephrine.

  4. that histone deacetylase 3 (show HDAC3 ELISA Kits) interaction with MeCP2 positively regulates a subset of neuronal genes through FOXO (show FOXO3 ELISA Kits) deacetylation, and disruption of HDAC3 (show HDAC3 ELISA Kits) contributes to cognitive and social impairment

  5. provide new insight into the upstream regulation of Sap90/Psd95 (show DLG4 ELISA Kits)-associated protein 3 (show HSPB3 ELISA Kits) and establish the essential role of striatal Hdac1 (show HDAC1 ELISA Kits), Hdac2 (show HDAC2 ELISA Kits) and MeCP2 for suppression of repetitive behaviors

  6. These findings position MeCP2 as a novel component in metabolic homeostasis. We previously showed that treatment of Mecp2 mice with statin drugs alleviated motor symptoms and improved health and longevity. Lipid metabolism is a highly treatable target; therefore, our results shed light on new metabolic pathways for treatment of Rett syndrome

  7. MeCP2 dysfunction in excitatory neurons mediated elevated synchrony at baseline, while MeCP2 dysfunction in inhibitory neurons increased susceptibility to hypersynchronization in response to perturbations.

  8. Loss of MeCP2 causes urological dysfunction and contributes to death by kidney failure in a mouse model of Rett syndrome.

  9. MeCP2 expression in the medullary respiratory network is sufficient for normal respiratory rhythm and preventing apnea. MeCP2 expression in the HoxA4 (show HOXA4 ELISA Kits) domain alone is critical for survival.

  10. Mecp2 is responsive to neuronal stimulation and IGF1 (show IGF1 ELISA Kits), and different stimuli have different effects on Mecp2 expression; this differential response may have downstream effects on functional mechanisms regulating brain development and plasticity.

Human Methyl CpG Binding Protein 2 (MECP2) interaction partners

  1. When it binds methylated/hydroxymethylated DNA, MeCP2 recruits various interacting protein and RNA partners, resulting in a highly specialized chromatin organization wherein linker histones and MeCP2 share an organizational role that dynamically changes during neuronal development. MeCP2 mutations alter its chromatin-binding dynamics and interactions with some of its partners, causing Rett syndrome. Review.

  2. MeCP2 regulates IGF1 (show IGF1 ELISA Kits) and BDNF (show BDNF ELISA Kits) levels, and when this gene is mutated both proteins have their expression decreased. In our study, we show that IGF1 (show IGF1 ELISA Kits) gene expression was not different between control and RTT neurons. Interestingly, IGF1R (show IGF1R ELISA Kits) has its gene expression increased in RTT neural cells compared to control

  3. The expression of Rb and MeCP2 in patients with B-cell non-Hodgkin's lymphoma (B-NHL (show RTEL1 ELISA Kits)) showed that positive staining for MeCP2 or Rb was significantly lower in B-NHL (show RTEL1 ELISA Kits) tumor tissues, and these changes were significantly and negatively correlated with the grade of B-NHL (show RTEL1 ELISA Kits).

  4. MECP2 was increased at both mRNA and protein levels in gastric cancer (GC) compared with paracancerous tissues; MECP2 positive expression was correlated with the TNM (show ODZ1 ELISA Kits) stages, histological types, and lymph node metastasis status, but not with sex or age; dysregulated expression of MECP2 in GC and its correlation to clinicopathological parameters indicate that MECP2 may regulate the development of GC

  5. that histone deacetylase 3 (show HDAC3 ELISA Kits) interaction with MeCP2 positively regulates a subset of neuronal genes through FOXO (show FOXO3 ELISA Kits) deacetylation, and disruption of HDAC3 (show HDAC3 ELISA Kits) contributes to cognitive and social impairment

  6. C- and N-terminal interactions are required for healthy function of MeCP2.

  7. These findings position MeCP2 as a novel component in metabolic homeostasis. We previously showed that treatment of Mecp2 mice with statin drugs alleviated motor symptoms and improved health and longevity. Lipid metabolism is a highly treatable target; therefore, our results shed light on new metabolic pathways for treatment of Rett syndrome

  8. Based on these findings, the authors suggest that MeCP2 recognition of methylated/hydroxymethylated CpA dinucleotides functions as an epigenetic switch redistributing MeCP2 among mCG and mCA loci.

  9. Following the recent demonstration of phenotype reversal in a mouse model of MECP2 Duplication, a clear understanding of the natural history is crucial to the design and implementation of future therapeutic strategies.

  10. we could not find any significant correlation between specific MECP2 mutations and individual clinical features or global clinical score in Rett syndrome patients

Methyl CpG Binding Protein 2 (MECP2) Antigen Profile

Antigen Summary

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

Alternative names and synonyms associated with Methyl CpG Binding Protein 2 (MECP2)

  • methyl CpG binding protein 2 (Rett syndrome) (MECP2) Elisa Kit
  • methyl CpG binding protein 2 (Mecp2) Elisa Kit
  • methyl CpG binding protein 2 (mecp2) Elisa Kit
  • methyl CpG binding protein 2 (Rett syndrome) (mecp2) Elisa Kit
  • 1500041B07Rik Elisa Kit
  • AUTSX3 Elisa Kit
  • BB130002 Elisa Kit
  • D630021H01Rik Elisa Kit
  • Mbd5 Elisa Kit
  • MRX16 Elisa Kit
  • MRX79 Elisa Kit
  • MRXS13 Elisa Kit
  • MRXSL Elisa Kit
  • PPMX Elisa Kit
  • RS Elisa Kit
  • RTS Elisa Kit
  • RTT Elisa Kit
  • WBP10 Elisa Kit
  • wu:fk96a04 Elisa Kit
  • zgc:111857 Elisa Kit

Protein level used designations for MECP2

meCp-2 protein , methyl-CpG-binding protein 2 , meCP-2 protein , methyl-CpG-binding protein MeCP2

GENE ID SPECIES
4204 Homo sapiens
17257 Mus musculus
29386 Rattus norvegicus
335250 Danio rerio
100328751 Oryctolagus cuniculus
398087 Xenopus laevis
612973 Canis lupus familiaris
539629 Bos taurus
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