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These results provide evidence of an association between a polymorphism in the MPPE1 gene and bipolar disorder.
cDNA cloning, genomic organization and expression of the novel human metallophosphoesterase gene MPPE1 on chromosome 18p11.2
Data demonstrate that glycosylphosphatidylinositol(GPI (show GNPDA1 Proteins)) glycan acts as an endoplasmic reticulum-exit signal and suggest that glycan remodeling mediated by PGAP5 regulates GPI (show GNPDA1 Proteins)-anchored proteins transport in the early secretory pathway.
Metallophosphoesterase required for transport of GPI- anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins (By similarity).
post-GPI attachment to proteins factor 5
, metallophosphoesterase 1
, metallo phosphoesterase
, Post-GPI attachment to proteins factor 5