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anti-Rat (Rattus) MTMR4 Antibodies:
anti-Human MTMR4 Antibodies:
anti-Mouse (Murine) MTMR4 Antibodies:
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Human Polyclonal MTMR4 Primary Antibody for IHC (p), WB - ABIN390777
Yu, Pan, Qin, Chen, Xu, Chen, Tang: MTMR4 attenuates transforming growth factor beta (TGFbeta) signaling by dephosphorylating R-Smads in endosomes. in The Journal of biological chemistry 2010
Show all 3 Pubmed References
Here the authors demonstrate that green fluorescent protein-tagged MTMR4 is recruited to the Salmonella-containing vacuole and infection of cells depleted of endogenous MTMR4 results in a decrease in viable intracellular Salmonella.
myotubularin-related protein 3 (show MTMR3 Antibodies) and myotubularin-related protein 4 may act as a bridge between CEP55 (show CEP55 Antibodies) and polo-like kinase 1 (show PLK1 Antibodies), ensuring proper CEP55 (show CEP55 Antibodies) phosphorylation and regulating CEP55 (show CEP55 Antibodies) recruitment to the midbody.
the PH-GRAM domain (show TBC1D8 Antibodies) of human MTMR4 was cloned, overexpressed in Escherichia coli, purified and crystallized by the vapour-diffusion method
MTMR4 is a necessary negative modulator for the homeostasis of BMP/Dpp (show TGFb Antibodies) signaling
MTMR4 localizes at the interface of early and recycling endosomes to regulate trafficking.
MTMR4 belongs to the myotubularin (show MTM1 Antibodies) family of phosphoinositides phosphatases
MTMR4 plays an important role in preventing the overactivation of TGFbeta (show TGFB1 Antibodies) signaling by dephosphorylating activated R-Smads that have been trafficked to early endosomes
Data found that hMTMR4 (human MTMR4) and Nedd4 co-immunoprecipitated and co-localized to late endosomes.
Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity).
myotubularin-related protein 4
, myotubularin related protein 4
, FYVE domain-containing dual specificity protein phosphatase 2
, zinc finger FYVE domain-containing protein 11
, zinc finger, FYVE domain containing 11
, FYVE zinc finger phosphatase