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Five single-nucleotide polymorphisms (SNPs) (rs9226, rs1045376, rs251684, rs2307279, and rs156631) in PLA2G4C and four SNPs (rs6533451, rs2285714, rs2285713, and rs11728699) in PLA2G12A (show PLA2G12A Proteins) were selected and genotyped. Our results showed a significant association between ASD (show ARSD Proteins) and the rs251684 variant of PLA2G4C. The rs251684 polymorphism of PLA2G4C may be associated with Autism Spectrum Disorder risk.
The A allele in PLA2G4C single nucleotide polymorphism (rs1549637) is associated with a worse prognosis in patients with colorectal cancer, especially in stage II.
Results demonstrated no significant impact of PLA2G6 (show PLA2G6 Proteins) and PLA2G4C gene polymorphisms on attenuated niacin skin flushing in schizophrenia patients.
site-specific cytosine methylation of the CpT (show CHPT1 Proteins) of PLA2G4C may play a role in the pathogenesis of schizophrenia.
These findings suggest that IVC-PLA(2 (show YWHAZ Proteins)) is involved in regulations of macrophage differentiation and macrophage polarization.
these results suggest that cPLA(2 (show PLA2G4A Proteins))gamma plays an important role in cancer cell chemotaxis.
Findings suggest that variation in PLA2G4C may influence preterm birth risk by increasing levels of prostaglandins, which are known to regulate labor.
cPLA(2 (show PLA2G4A Proteins)) has a role in the induction of cell autonomous cellular immunity to Chlamydia
Novel PLA2G4C polymorphism as a molecular diagnostic A minisatellite polymorphism in the untranslated region of exon 1, with allelic variants that have one, two or three 27-bp repeats
TNF-alpha (show TNF Proteins) & IFN-gamma (show IFNG Proteins) induce gene expression of a novel cytosolic PLA(2 (show PLA2G4A Proteins)) IVC in human airway epithelial cells. The possibility that it is involved in cytokine-mediated inflammation in the respiratory tract is inferred.
This gene encodes a protein which is a member of the phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound enzyme. Multiple transcript variants encoding different isoforms have been found for this gene.
cytosolic phospholipase A2 gamma
, phospholipase A2 group IVC