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Serial deletion analysis identified the core PLC-delta4 promoter region as being between -402 and -67, in which an E-box and an AP-1 (show FOSB ELISA Kits) binding site played important roles in the promoter activity.
We identify PLCdelta4 as a PLC (show HSPG2 ELISA Kits) isoform important in the regulation of TRPM8 (show TRPM8 ELISA Kits) both at the cellular level and in vivo
These findings highlight a novel pathway by which nuclear PLCs affect insulin (show INS ELISA Kits) secretion and identify PPARgamma (show PPARG ELISA Kits) as a novel molecular target of nuclear PLCs.
PLCd4 has a role in the zona pellucida-induced acrosome reaction in mice
It is concluded that PLC delta4 regulates the liver regeneration in cooperation with nuclear PKC alpha (show PKCa ELISA Kits) and epsilon
PLCd4 is required for the acrosome reaction in fertilization.
This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer.
phospholipase C, eta 1
, phospholipase C-like 3
, phospholipase C, delta 4
, phospholipase C delta 4
, DrPLC-delta 4A
, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4
, phosphoinositide phospholipase C-delta-4
, phospholipase C-delta-4
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4-like
, PLC delta4
, phosphoinositide phospholipase C delta-4
, phospholipase C-delta-2
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 4