Browse our ITGA5 Proteins (ITGA5)

On are 18 Integrin, alpha 5 (Fibronectin Receptor, alpha Polypeptide) (ITGA5) Proteins from 6 different suppliers available. Additionally we are shipping ITGA5 Antibodies (416) and ITGA5 Kits (14) and many more products for this protein. A total of 456 ITGA5 products are currently listed.
CD49e, FNRA, ITGA5, Itga5_retired, VLA5, VLA5A
list all proteins Gene Name GeneID UniProt
ITGA5 16402 P11688
ITGA5 3678 P08648
Rat ITGA5 ITGA5 315346  

ITGA5 Proteins (ITGA5) by Origin

More Proteins for ITGA5 Interaction Partners

Mouse (Murine) Integrin, alpha 5 (Fibronectin Receptor, alpha Polypeptide) (ITGA5) interaction partners

  1. FAK sustained the active integrin conformation by maintaining talin association with Rab11 endosomes in a type I phosphatidylinositol phosphate kinase (PIPKIgamma)-dependent manner.

  2. cells on fibronectin (show FN1 Proteins) suppressed cAMP via enhanced phosphodiesterase (PDE (show TWIST1 Proteins)) activity, through direct binding of integrin alpha5 to phosphodiesterase-4D5

  3. this study shows that protective effect of osteopontin (show SPP1 Proteins) results from integrin-alpha5-dependent enhancement of neutrophil migration and accumulation at sites of infection

  4. Gdf-5 (show GDF5 Proteins) induced the expression of the alpha5 sub-unit, while Bmp-7 (show BMP7 Proteins) induced the expression of the alphaV sub-unit.

  5. EGFR (show EGFR Proteins) activation can be regulated by the N-glycosylation of integrin alpha5, which is a novel molecular paradigm for the cross-talk between integrins and growth factor receptors

  6. An (as yet unknown) integrin alpha5-dependent signal extrinsic to the pharyngeal endothelium mediates the formation of the 4th pharyngeal arch arteries through fibronectin (show FN1 Proteins).

  7. Suggest that alpha5beta1-mediated cross-talk between fibronectin (show FN1 Proteins) and oxLDL regulates inflammation in early atherogenesis and that therapeutics that inhibit alpha5 integrins may reduce inflammation without adversely affecting plaque structure.

  8. our data point to a potential role for the fibronectin (show FN1 Proteins)-alpha5beta1 integrin interaction in promoting vascular remodeling during demyelinating disease

  9. high expression of the ppGalNAc-T13 (show GALNT13 Proteins) gene generates tTn (show TTN Proteins) antigen on Syndecan 1 (show SDC1 Proteins), leading to enhanced invasion and metastasis via the formation of a complex consisting of integrin alpha5beta1, Syndecan 1 (show SDC1 Proteins), and MMP-9 (show MMP9 Proteins) in the glycolipid-enriched microdomain/rafts.

  10. Fibronectin (show FN1 Proteins) and integrin alpha5beta1 have critical roles in mouse embryogenesis

Human Integrin, alpha 5 (Fibronectin Receptor, alpha Polypeptide) (ITGA5) interaction partners

  1. Eps8 (show EPS8 Proteins)/Abi1 (show ABI1 Proteins)/Sos1 (show SOS1 Proteins) tricomplex acts as a key molecular switch altering the balance between Rac1 and Rho activation; its presence or absence in pancreatic ductal adenocarcinoma cells modulates alphavbeta6-dependent functions, resulting in a pro-migratory (Rac1-dependent) or a pro-TGF-beta1 (show TGFB1 Proteins) activation (Rho-dependent) functional phenotype.

  2. Findings indicate integrin inhibition as a promising strategy to block both aryl hydrocarbon receptor (AhR (show AHR Proteins)) and transforming growth factor beta (TGF-beta)-controlled features of malignancy in glioblastoma.

  3. Suggest an adhesion-dependent mechanism of RUNX2 (show RUNX2 Proteins) for the osteotropism and bone colonization of breast cancer cells and implicate RUNX2 (show RUNX2 Proteins) and integrin alpha5 as potential molecular markers for the prediction of bone metastasis.

  4. cells on fibronectin (show FN1 Proteins) suppressed cAMP via enhanced phosphodiesterase (PDE (show ALDH7A1 Proteins)) activity, through direct binding of integrin alpha5 to phosphodiesterase-4D5

  5. Data show that high mobility group nucleosomal binding domain 2 (HMGN2 (show HMGN2 Proteins)) knockdown induced the increased expression of alpha5beta1 integrin on cell membranes, which resulted in a significant increase in Klebsiella pneumoniae internalization.

  6. ITGA5 expression is significantly upregulated in human masticatory mucosa during wound healing

  7. ectopic expression of miR-17 in ovarian cancer cells resulted in repressed ILK (show ILK Proteins) phosphorylation as well as decreased production of active matrix metalloproteinase-2 (MMP-2 (show MMP2 Proteins)). Our results indicated that miR-17 hampered ovarian cancer peritoneal propagation by targeting integrin a5 and b1.

  8. These results suggest that downregulation of miR (show MLXIP Proteins)-330-5p expression may affect Colorectal cancerdevelopment via modulation of ITGA5 expression.

  9. In colorectal cancer cells, miR (show MLXIP Proteins)-130b directly targeted the 3' untranslated region (3'UTR) region of integrin alpha5 gene, which encodes a key molecule involved in cell motility. TGF-beta1 (show TGFB1 Proteins) acted through miR (show MLXIP Proteins)-130b to promote integrin alpha5 expression, resulting in the enhanced migration of CRC (show CALR Proteins) cells.

  10. upregulation of miR (show MLXIP Proteins)-31 targeting ITGA5 may suppress tumor cell invasion and metastasis by indirectly regulating PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling pathway in human SGC7901 GC cells

Cow (Bovine) Integrin, alpha 5 (Fibronectin Receptor, alpha Polypeptide) (ITGA5) interaction partners

  1. Putative function of fibronectin (show FN1 Proteins) and its receptor (integrin alpha(5)beta(1)) in male and female gametes during bovine fertilization in vitro.

  2. Results indicate that XIAP (show XIAP Proteins) stabilizes the alpha(5)-integrin-associated focal adhesion complex, thereby further regulating endothelial cell adhesion and migration.

  3. alphavbeta3 integrin engagement in vascular endothelium regulates Ca2 (show CA2 Proteins)+-dependent K+ current

  4. Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.

ITGA5 Protein Profile

Protein Summary

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

Alternative names and synonyms associated with ITGA5

  • integrin, alpha 5 (fibronectin receptor, alpha polypeptide) (ITGA5)
  • integrin alpha 5 (fibronectin receptor alpha) (Itga5)
  • integrin, alpha 5 (fibronectin receptor, alpha polypeptide) (Itga5)
  • CD49e protein
  • FNRA protein
  • ITGA5 protein
  • Itga5_retired protein
  • VLA5 protein
  • VLA5A protein

Protein level used designations for ITGA5

integrin, alpha 5 (fibronectin receptor, alpha polypeptide) , CD49 antigen-like family member E , fibronectin receptor alpha polypeptide , fibronectin receptor subunit alpha , integrin alpha-5 , integrin alpha-F , VLA-5 , fibronectin receptor, alpha subunit , very late activation protein 5, alpha subunit , integrin alpha 5 (fibronectin receptor alpha)

486493 Canis lupus familiaris
100606925 Nomascus leucogenys
16402 Mus musculus
3678 Homo sapiens
315346 Rattus norvegicus
281873 Bos taurus
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