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We found that quercetin reduces the promoter activity of apoB (show APOB ELISA Kits), driven by the enforced expression of C/EBPb.
Chromatin immunoprecipitation analysis revealed that C/EBPbeta2 binds to multiple sites at the 5' promoter/regulatory region, introns, and the 3' untranslated region of the IGF-II gene.
Study results show the role of WT1 (show WT1 ELISA Kits) in regulating decidualization in human endometrial stromal cells. C/EBPbeta is an upstream gene that regulates WT1 (show WT1 ELISA Kits) expression by binding to the novel enhancer region.
EGFR (show EGFR ELISA Kits) and C/EBP-beta oncogenic signaling is bidirectional in human glioma and varies with the C/EBP-beta isoform
Studied expression of CD147 in both ALK (show ALK ELISA Kits)+ and ALK (show ALK ELISA Kits)- anaplastic large-cell lymphoma; found CD147 to be a downstream target for activation by C/EBPbeta.
Data show that in an in vitro acute lung injury model established by lipopolysaccharide induction, phosphorylation of C/EBP beta was decreased and bioinformatics analysis discovered a putative binding site of C/EBP beta in CCSP1 (show KIAA1199 ELISA Kits) promoter; LPS (show IRF6 ELISA Kits) stimulation reduced C/EBP beta phosphorylation and suppressed the transcription of CCSP1 (show KIAA1199 ELISA Kits).
Increased polyamine metabolism in CRC (show CALR ELISA Kits) could be driven by c-Myc (show MYC ELISA Kits) and C/EBPbeta rather than Bacteroides fragilis infection.
SBDS (show SBDS ELISA Kits) function is specifically required for efficient translation re-initiation into the protein isoforms C/EBPalpha (show CEBPA ELISA Kits)-p30 (show CENPV ELISA Kits) and C/EBPbeta-LIP, which is controlled by a single cis (show CISH ELISA Kits)-regulatory upstream open reading frame (uORF) in the 5' untranslated regions (5' UTRs) of both mRNAs.
A transcription factor complex consisting of ATF6 (show ATF6 ELISA Kits) (an endoplasmic reticulum-resident factor) and C/EBP-beta is required for the IFN-gamma-induced (show SAMHD1 ELISA Kits) expression of DAPK1 (show DAPK1 ELISA Kits) IFN-gamma-induced (show SAMHD1 ELISA Kits) proteolytic processing of ATF6 (show ATF6 ELISA Kits) and phosphorylation of C/EBP-beta are obligatory for the formation of this transcriptional complex
Data show that CCAAT/enhancer-binding protein beta (C/EBP beta) expression is increased in endothelial cells and retinal pigment epithelial cells infected by Toxoplasma gondii, resulting in the activation of autophagy in host cells by inhibiting mechanistic target of rapamycin (show FRAP1 ELISA Kits) protein (mTOR (show FRAP1 ELISA Kits)) pathway.
Data suggest that melatonin down-regulates adipogenesis via reduction of (a) cAMP synthesis, (b) reactive oxygen species synthesis, (c) phosphorylation of CEBPB (CCAAT-enhancer-binding protein-beta), and (d) activation of GSK3B (glycogen synthase kinase 3 beta (show GSK3b ELISA Kits)); primary mesenchymal stem cells cultured in adipogenic differentiation media were used in these studies.
we concluded that staurosporine enhanced ATRAinduced granulocytic differentiation in U937 cells via MEK (show MAP2K1 ELISA Kits)/ERK (show EPHB2 ELISA Kits)-mediated modulation of the protein level of C/EBPs
Functional characterization of C/EBPa (show CEBPA ELISA Kits) and C/EBPb proteomes suggests they can regulate novel pathways.
PARP-1 (show PARP1 ELISA Kits) attenuates adipogenesis by PARylating C/EBPb, a pro-adipogenic transcription factor, on three residues in its regulatory domain.
Results show that C/EBPbeta and C/EBPdelta (show CEBPD ELISA Kits) actively regulate the promotor region of both splicing variants Ppargamma1sv and Ppargamma2 (show PPARG ELISA Kits) in mouse adipocytes.
These results show that C/EBPbeta directs a switch from proinflammatory to repressor myeloid cells
Both gain- and loss-of-function studies showed that an accumulation of the CCAAT/enhancer binding protein-beta (C/EBP-beta) protein, which cooperates with dominant transcriptional co-regulator PR domain containing 16 (PRDM16 (show PRDM16 ELISA Kits)) to determine brown/beige (show LYST ELISA Kits) adipocyte lineage, is essential for the enhanced adipocyte browning caused by the loss of ZIP13 (show SLC39A13 ELISA Kits)
monocyte differentiation occurred through de novo enhancer establishment and activation of pre-established (poised) enhancers. Generation of Ly6C(-) monocytes involved induction of the transcription factor C/EBPbeta and C/EBPbeta-deficient mice lacked Ly6C(-) monocytes.
Intra-tumor IL-6 (show IL6 ELISA Kits), C/EBP-beta and PPAR-gamma (show PPARG ELISA Kits) expression correlated with intramuscular liposarcoma growth in mice and autophagy.
these findings highlight a critical role of TSC1 (show TSC1 ELISA Kits) in regulating innate immunity by control of the mTOR1-C/EBPbeta pathway.
Expression of miR (show MLXIP ELISA Kits)-26a or knockdown of Klf4 (show KLF4 ELISA Kits) or Creb (show CREB1 ELISA Kits) or C/ebpbeta, attenuated the survival of Mycobacterium tuberculosis in macrophages.
Runx2 (show RUNX2 ELISA Kits) might act downstream of C/EBPbeta to regulate the expression of Cox-2 (show COX2 ELISA Kits), Vegf (show VEGFA ELISA Kits) and Mmp9 (show MMP9 ELISA Kits) in the uterine stromal cells.
C/EBP-beta plays a vital role in regulating GPR120 (show O3FAR1 ELISA Kits) transcription.
The expression of porcine Prdx6 (show PRDX6 ELISA Kits) gene is up-regulated by C/EBPbeta and CREB (show CREB1 ELISA Kits).
Results show that expression changes of IGF1 (show IGF1 ELISA Kits) genes were associated with C/EBP (show CEBPA ELISA Kits) b expression during embryonic and postnatal development in porcine liver.
FoxO1 (show FOXO1 ELISA Kits) and C/EBPb regulate preadipocyte adipogenesis possibly through C/EBPb-> FoxO1 (show FOXO1 ELISA Kits)-> C/EBPb feedback regulatory loop and FoxO1 (show FOXO1 ELISA Kits)-C/EBPb protein complex.
the pig GPD1 (show GPD1 ELISA Kits) gene is regulated negatively by C/EBP beta in cultured kidney cells
GATA-4 (show GATA4 ELISA Kits) and C/EBPbeta are both required for FSH (show BRD2 ELISA Kits) +/- IGF-I (show IGF1 ELISA Kits) stimulation of the porcine steroidogenic acute regulatory protein (show STAR ELISA Kits) gene promoter in homologous granulosa cell cultures.
The differential expression of specific CEBPA (show CEBPA ELISA Kits)/B isoforms observed in maturing follicles and CL may contribute to changes in follicular cell differentiation and increasing steroidogenic capacity.
SREBP1a activated while C/EBP (show CEBPA ELISA Kits) factors downregulated the activity of the SCD1 (show SCD ELISA Kits) promoter.
These results indicate that the C/EBPbeta gene plays an important regulatory role in regulation of the cell cycle regulators and spermatogenesis-related (show SYCE2 ELISA Kits) genes expression and function of bovine SCs (show TWIST1 ELISA Kits).
Suppression of CPT1B (show CPT1B ELISA Kits) and induction of SCD (show SCD ELISA Kits) and CEBPB by supplemental arginine promotes increased adiposity in Angus steers.
Co-culture of adipocytes and myoblasts elicited an increase in C/EBPbeta and PPAR-gamma (show PPARG ELISA Kits) gene expression in differentiated myoblasts and an increase in GPR43 (show FFAR2 ELISA Kits) gene expression in adipocytes.
Interaction of C/EBP-beta and NF-Y factors constrains activity levels of the nutritionally controlled promoter IA expressing the acetyl-CoA carboxylase-alpha (show ACACA ELISA Kits) gene in cattle.
The role of NF-kappaB (show NFKB1 ELISA Kits) and C/EBP (show CEBPA ELISA Kits) factors in regulating basal and pathogen-induced expression of both genes from cattle, is investigated.
The 3' terminal end of the first intron of porcine SPP1 (show SPP1 ELISA Kits) harbors a C/EBPbeta binding site and this binding site is negatively affected by the mutant G allele.
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene.
CCAAT/enhancer binding protein (C/EBP), beta
, CCAAT/enhancer-binding beta protein b
, CCAAT/enhancer-binding protein beta
, CCAAT/enhancer binding protein beta
, interleukin 6-dependent DNA-binding protein
, liver-enriched transcriptional activator protein
, nuclear factor NF-IL6
, nuclear factor of interleukin 6
, transcription factor 5
, C/EBP BETA
, interleukin-6-dependent-binding protein
, liver-enriched transcriptional activator
, nuclear protein Il6
, C/EBP beta
, c/EBP-related protein 2
, liver activating protein (LAP)
, nuclear factor-IL6
, silencer factor B
, c/EBP beta
, CCAAT box/enhancer binding protein beta
, CCR protein
, transcription factor NF-M