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C3G stimulates guanine nucleotide exchange on Drosophila Rap (show LRPAP1 ELISA Kits) GTPases in vitro
the N terminus of C(3)G is critical for the formation of antiparallel pairs of C(3)G homodimers that span the central region and thus for assembly of complete TFs, while the C terminus is required to affix these homodimers to the lateral elements.
C3G/RAP1 activity is involved in the metastatic spread of epithelial ovarian cancer.
C3G plays an important role in platelet clotting through a mechanism involving its GEF activity and suggest that it might be also involved in neutrophil development.
The possibility of cellular phospho-C3G (pC3G) being a substrate of the intracellular T-cell protein tyrosine phosphatase TC-PTP (show PTPN2 ELISA Kits) (PTPN2 (show PTPN2 ELISA Kits)) using the human neuroblastoma (show ARHGEF16 ELISA Kits) cell line, was studied.
Lyn (show LYN ELISA Kits) controls spatial activation of Rap1 (show RABGEF1 ELISA Kits) by recruiting the CrkL (show CRKL ELISA Kits)-C3G protein complex to the leading edge
found somatic demethylation of a relaxed-criterion CpG island (CGI-B) located in the first intron of RAPGEF1 in 40% of colon cancers and 8% of gastric cancers relative to their matching normal tissues that were always methylated
Data demonstrated that the polymorphism in TP53 (show TP53 ELISA Kits) (rs1042522) was associated with type 2 diabetes, and that potential interaction of TP53 (show TP53 ELISA Kits) (rs1042522) and RAPGEF1 (rs11243444), or NRF1 (show NFE2L1 ELISA Kits) (rs1882095) increased the risk of type 2 diabetes.
significant positive correlation between layers II and IV of the dorso-lateral prefrontal cortex in the percentage of MR-GEF expressing neurons in individuals with bipolar disorder
C3G overexpression induces neurite-like extensions in MDA-MB-231 and BT549 breast carcinoma cells and not in a variety of other cancer cell lines examined.
C3G as a novel target of c-Abl
ALK (show ALK ELISA Kits) activation of Rap1 (show RABGEF1 ELISA Kits) via the Rap1 (show RABGEF1 ELISA Kits)-specific GEF C3Gmay contribute to cell proliferation and oncogenesis of neuroblastoma (show ARHGEF16 ELISA Kits).
C3G is required in cortical neurons for both the specification of an axon and the initiation of radial migration by forming a leading process.
results provide evidence that C3G plays an important role in myogenic differentiation by coordinating cell cycle exit, actin dynamics and survival signaling.
C3G regulates sympathetic preganglionic neuron migration by acting downstream in the reelin (show RELN ELISA Kits) signaling pathway.
Data indicate that chemical rescue of c-Src provided a tool to dissect the spatiotemporal mechanism of activation of the Rap1 guanine exchange factor, C3G, one of the identified potential c-Src substrates that plays a role in focal adhesion signaling.
GEF and Dlx1/2 form part of a common signalling pathway during GABAergic neuronal development.
Guanine nucleotide releasing factor 2 (show RASGRF2 ELISA Kits) is a negative regulator of Mitogen-Activated Protein Kinase 14 (show MAPK14 ELISA Kits) in mouse embryonic fibroblasts and can promote cell survival or cell death depending on the stimuli.
Targeted disruption of Ras-Grf2 (show RASGRF2 ELISA Kits) shows its dispensability for mouse growth and development.
These results show that C3G is required for (1) vascular myogenesis, (2) the formation of paxillin (show PXN ELISA Kits)- and integrin beta1-positive, but not integrin beta3-positive, cell adhesions and (3) normal response to PDGF (show PDGFA ELISA Kits), necessary for vascular myogenesis.
roles of C3G-Rap1 signaling pathway in various biological processes
Our results show that the size of the cortical neural precursor population is controlled by C3G-mediated inhibition of the Ras signalling pathway.
the SSC5:60296617 SNP may affect teat number by regulating the interaction of EPS8 (show EPS8 ELISA Kits) and RAPGEF1 and, finally, affecting the mammogenesis of pigs
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.
CRK SH3-binding GNRP
, guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene)
, rap guanine nucleotide exchange factor 1
, guanine nucleotide releasing factor 2
, guanine nucleotide-releasing factor 2
, Rap guanine nucleotide exchange factor (GEF) 1
, rap guanine nucleotide exchange factor 1-like