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anti-Rat (Rattus) RAPGEFL1 Antibodies:
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C3G/RAP1 activity is involved in the metastatic spread of epithelial ovarian cancer.
C3G (show RAPGEF1 Antibodies) plays an important role in platelet clotting through a mechanism involving its GEF (show SLC2A4RG Antibodies) activity and suggest that it might be also involved in neutrophil development.
The possibility of cellular phospho-C3G (show RAPGEF1 Antibodies) (pC3G) being a substrate of the intracellular T-cell protein tyrosine phosphatase TC-PTP (show PTPN2 Antibodies) (PTPN2 (show PTPN2 Antibodies)) using the human neuroblastoma (show ARHGEF16 Antibodies) cell line, was studied.
Lyn (show LYN Antibodies) controls spatial activation of Rap1 (show RABGEF1 Antibodies) by recruiting the CrkL (show CRKL Antibodies)-C3G (show RAPGEF1 Antibodies) protein complex to the leading edge
found somatic demethylation of a relaxed-criterion CpG island (CGI-B) located in the first intron of RAPGEF1 (show RAPGEF1 Antibodies) in 40% of colon cancers and 8% of gastric cancers relative to their matching normal tissues that were always methylated
Data demonstrated that the polymorphism in TP53 (show TP53 Antibodies) (rs1042522) was associated with type 2 diabetes, and that potential interaction of TP53 (show TP53 Antibodies) (rs1042522) and RAPGEF1 (show RAPGEF1 Antibodies) (rs11243444), or NRF1 (show NFE2L1 Antibodies) (rs1882095) increased the risk of type 2 diabetes.
significant positive correlation between layers II and IV of the dorso-lateral prefrontal cortex in the percentage of MR-GEF (show RAPGEF5 Antibodies) expressing neurons in individuals with bipolar disorder
C3G (show RAPGEF1 Antibodies) overexpression induces neurite-like extensions in MDA-MB-231 and BT549 breast carcinoma cells and not in a variety of other cancer cell lines examined.
C3G as a novel target of c-Abl
ALK (show ALK Antibodies) activation of Rap1 (show RABGEF1 Antibodies) via the Rap1 (show RABGEF1 Antibodies)-specific GEF (show SLC2A4RG Antibodies) C3Gmay contribute to cell proliferation and oncogenesis of neuroblastoma (show ARHGEF16 Antibodies).
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.
Rap guanine nucleotide exchange factor (GEF)-like 1
, rap guanine nucleotide exchange factor 1
, CRK SH3-binding GNRP
, guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene)
, Link guanine nucleotide exchange factor II
, RAP guanine-nucleotide-exchange factor (GEF)-like 1
, link GEFII
, rap guanine nucleotide exchange factor-like 1