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Findings suggested FOXA1 may act as an anti-oncogene (show RAB1A Proteins) in gastric cancer (GC) cells. Low-level expression of FOXA1 protein was confirmed in GC tissues and cell lines. FOXA1 over-expression could significantly affect cell proliferation, apoptosis and tumor invasion of GC cells, which may be resulted by reversing EMT (show ITK Proteins).
High expression of FOXA1 is an independent prognostic parameter in ERG (show ERG Proteins) negative prostate cancer
A molecular mechanism by which Estradiol antagonizes GR-dependent induction of specific genes by preventing the recruitment of the pioneer factors FOXA1 and FOXA2 (show FOXA2 Proteins) in a physiologically relevant model.
Results show that c-Abl (show ABL1 Proteins) phosphorylates FoxA1 at multiple sites. Tyr429 and Tyr464 were identified as the major phosphorylation sites in the FoxA1 C-terminal region. This c-Abl (show ABL1 Proteins)-mediated phosphorylation of FoxA1 promotes the activation of estrogen signaling by inducing its binding to histones.
MLL3 binding was dependent on FOXA1, indicating that FOXA1 recruits MLL3 to chromatin. MLL3 silencing decreased H3K4me1 at enhancer elements but had no appreciable impact on H3K4me3 at enhancer elements. We propose a mechanism whereby the pioneer factor FOXA1 recruits the chromatin modifier MLL3 to facilitate the deposition of H3K4me1 histone marks, subsequently demarcating active enhancer elements
FoxA1 discriminates between medullary thyroid carcinoma and tumors of follicular derivation with sensitivity and specificity greater than calcitonin (show CALCA Proteins) and carcinoembryonic antigen (show CEACAM5 Proteins).
FOXA1 loss may play a significant role in enabling prostate cancer progression to neuroendocrine prostate cancer, whereas IL-8 (show IL8 Proteins) and MAPK/ERK (show MAPK1 Proteins) pathways may be promising targets for therapeutic intervention.
Low FOXA1 expression is associated with breast cancer invasion and metastasis.
the distinct mechanisms by which GATA2 (show GATA2 Proteins) and FOXA1 regulate AR cistrome and suggest that FOXA1 acts upstream of GATA2 (show GATA2 Proteins) and AR in determining hormone-dependent gene expression in prostate cancer.
Study implicates enhancer reprogramming, FOXA1 upregulation, and a retrograde developmental transition in pancreatic ductal adenocarcinoma metastasis.
this model system will facilitate further in vivo functional studies of Foxa1 or other factors in mammary gland development and tumor formation and progression
Loss of Interdependent Binding by the FoxO1 (show FOXO1 Proteins) and FoxA1/A2 Forkhead Transcription Factors Culminates in Perturbation of Active Chromatin Marks and Binding of Transcriptional Regulators at Insulin (show INS Proteins)-sensitive Genes.
FoxA1, FoxA2 (show FOXA2 Proteins), and LIPG (show LIPG Proteins) control the uptake of extracellular lipids for breast cancer growth.
genome-wide binding sites of the forkhead/winged helix transcription factor (show FOXP2 Proteins) Foxa1, which functions redundantly with Foxa2 (show FOXA2 Proteins) to regulate the differentiation of midbrain dopamine neurons, were characterized.
Disruption of Shp (show LAMC1 Proteins) in mice alters timing of expression of genes that regulate homocysteine metabolism and the liver responses to ethanol and homocysteine. SHP (show LAMC1 Proteins) inhibits the transcriptional activation of Bhmt (show BHMT Proteins) and cystathionine gamma-lyase (show CTH Proteins) by FOXA1.
ChIP-exonuclease of the ER pioneer factor FoxA1 identifies protected DNA with a predictable 8 bp overhang from the Forkhead motif, which authors term mesas; showed that mesas occur in multiple cellular contexts and exist as single or overlapping motifs.
TIP30 (show HTATIP2 Proteins) is a key regulator for maintaining ER(+) and ER(-)luminal pools in the mammary luminal lineage via FoxA1.
Mechanistically, JARID1B (show KDM5B Proteins) was required for GATA3 (show GATA3 Proteins) recruitment to the Foxa1 promoter to activate Foxa1 expression.
Foxa1 recruited Grg3 to the Nanog (show NANOG Proteins) promoter -2kb upstream region and switched the promoter to an inactive chromatin status represented by typical modifications in histone H3 (show HIST3H3 Proteins).
Results indicate Foxa1 expression is required for the maintenance of prostatic cellular differentiation.
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.
forkhead box A1
, forkhead box protein A4
, HNF-3 alpha
, HNF3 alpha
, forkhead box protein A1
, forkhead transcription factor FoxA1
, forkhead homolog
, hepatocyte nuclear factor 3-alpha-like
, fork head domain protein 7
, hepatocyte nuclear factor 3-alpha
, HNF3alpha homolog B
, fork head domain-related protein 7'
, forkhead box protein A1-B
, forkhead protein 2
, hepatocyte nuclear factor 3-alpha homolog B
, transcription factor 3A
, hepatocyte nuclear factor 3 alpha
, fork head domain
, hepatocyte nuclear factor 3 alpha (winged helix transcription factor)
, hepatocyte nuclear factor 3, alpha