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INVESTIGATION OF STAT5A (show STAT5A ELISA Kits), FSHR AND LHR (show LHCGR ELISA Kits) GENE POLYMORPHISMS IN TURKISH INDIGENOUS CATTLE BREEDS
The expression of FSHR mRNA in granulosa cells was highest in small antral follicles, then decreased significantly as follicles increased in size, and was lowest in cysts.
transfer. We conclude that variation at these loci of the FSHR gene has no significant effect on pregnancy rates in Luxi cattle.
Specific alleles of the bovine FSHR gene are associated with variations in embryo yield and in the number of unfertilised oocytes.
This study evaluated the relationships among aromatase (show CYP19A1 ELISA Kits), IGF-1 (show IGF1 ELISA Kits), IGF2R (show IGF2R ELISA Kits), and follicle stimulating hormone (FSH) receptor levels expressed in ovarian follicles of cattle selected for twin pregnancies.
granulosa cell clustering is accompanied by marked increases in FSHr, IGF-1r (show IGF1R ELISA Kits), and p450 arom (show CYP19A1 ELISA Kits) expression, and precedes induction and subsequent peak E2 production
Dominant follicles experience a reduction in FSH (show BRD2 ELISA Kits) dependence (diminished expression of FSHR), but acquire increased LH dependence (enhanced expression of LHCGR (show LHCGR ELISA Kits)) as they grow during the low FSH (show BRD2 ELISA Kits) milieu of follicular waves.
FSHR is specifically regulated through androgen receptor (show AR ELISA Kits) in granulosa cells
Heterozygous heifers showed a higher pregnancy rate (67 and 66% for LHR (show LHCGR ELISA Kits) and FSHR genes, respectively), but no significant effects were observed for the genes studied (
Data show that double mutation of follicle-stimulating hormone receptor (fshr) and luteinizing hormone receptor (lhcgr (show LHCGR ELISA Kits)) resulted in infertile males.
Data show for the first time in a vertebrate species that Leydig cells as well as Sertoli cells express the mRNAs for both fshr and lhcgr (show LHCGR ELISA Kits).
Characterization of the first functional zebrafish (Danio rerio) gonadotropic hormone I receptor (follicle stimulating hormone receptor).
The mutation p.R59X in FSHR is causative for primary ovarian insufficiency by means of arresting folliculogenesis.
two mutations, V(221)G and T(449)N, in the extracellular domain and transmembrane helix 3, of FSHR, respectively, are reported.
The reduced fertilisation and pregnancy rate was associated with a lower LH receptor (show LHCGR ELISA Kits) density and a lack of essential down-regulation of the FSH (show BRD2 ELISA Kits) and LH receptor (show LHCGR ELISA Kits).
This work demonstrates that the expression of FSHR and LHCGR (show LHCGR ELISA Kits) can be induced in hGL5 cells but that the FSHR-dependent cAMP/PKA pathway is constitutively silenced, possibly to protect cells from FSHR-cAMP-PKA-induced apoptosis.
The incidence of the Ser/Ser (show SIGLEC1 ELISA Kits) genotype was higher in patients with higher recombinant human follicle-stimulating hormone consumption. Based on our results, we hypothesize an association between the follicle-stimulating hormone receptor polymorphisms and a "hyporesponse" to exogenous follicle-stimulating hormone.
The data suggest novel follicle-stimulating hormone receptor expression in endometriotic lesions, qualitatively and quantitatively different from that of normal endometrium.
Genetic variation affecting FSH (show BRD2 ELISA Kits) production (FSHB (show FSHB ELISA Kits) c.-211G>T) was associated with age at pubertal onset, as assessed by testicular enlargement. The effect appeared further modified by coexistence of genetic variation affecting FSH (show BRD2 ELISA Kits) sensitivity (FSHR c.-29G>A).
Novel mutations, c.419delA and c.1510C>T of the FSHR gene were associated with resistant ovarian syndrome.
Association of the FSHR G-29A, 919A > G, 2039A > G polymorphisms with male infertility in Han-Chinese
A polymorphism within the promoter of FSHR is determined to not be associated with ovarian reserve or response to controlled ovarian hyperstimulation.
Study demonstrates expression of follicle-stimulating hormone receptor (FSHR) and a direct action of follicle-stimulating hormone on testicular stem/germ cells possibly mediated via alternatively spliced growth factor type 1 receptor FSHR3 in mice.
FSHR and LHR (show LHCGR ELISA Kits) proteins are significantly upregulated in CCs (show CCS ELISA Kits) surrounding oocytes arrested at the 2-cell stage, reflecting their developmental incompetence.
Triptorelin and cetrorelix induce immune responses and affect uterine development and expressions of genes and proteins of ESR1 (show ESR1 ELISA Kits), LHR (show LHCGR ELISA Kits), and FSHR
Brca1 (show BRCA1 ELISA Kits)(GC-/-) models reveal that specific intra-follicular Brca1 (show BRCA1 ELISA Kits) loss alone, or combined with cancer-promoting genetic (Trp53 (show TP53 ELISA Kits) loss) and endocrine (high serum follicle-stimulating hormone) changes, was not sufficient to cause ovarian tumors.
Data (including date from knockout mice) suggest that Fshr is expressed early in pregnany in placenta and other extragonadal tissues of fetoplacental unit; expression is particularly strong at term.
Sertoli cell-specific expression of MTA2 (show MTA2 ELISA Kits) is required for transcriptional regulation of FSHR gene during spermatogenesis.
By day 20 and in adult animals total AR or FSHR ablation significantly reduced Leydig cell numbers but Sertoli cell specific AR ablation had no effect.
The results demonstrate that gain-of-function mutations of the FSHR in mice bring about distinct and clear changes in ovarian function
haploinsufficiency of the follicle-stimulating hormone receptor accelerates oocyte loss inducing early reproductive senescence and biological aging in mice
show that FSH-R haploinsufficiency leads to a decrease in ovulation, altered ovarian steroidogenesis, and neuroendocrine impairments resulting in early reproductive senescence
The amount of dopamine d1 receptor (show DRD1 ELISA Kits), dopamine D2 receptor (show DRD2 ELISA Kits), and follicle stimulating hormone receptor (FSHr) mRNA were quantified in ovarian tissues in anestrous and mares expressing estrus during the breeding season are reported.
Activated TGF-beta (show TGFB1 ELISA Kits) signaling rescued miR (show MYLIP ELISA Kits)-143-reduced FSHR and intracellular signaling molecules, and miR (show MYLIP ELISA Kits)-143-induced porcine granulosa cell apoptosis.
The results showed that polymorphisms in exon 10 of the FSHR gene had a significant effect on litter size traits of Wannan Black and Berkshire pigs. These results can be applied for marker-assisted selection in the 2 swine breeds
These results showed that an increased FSHR gene expression level was accompanied with an increase in histone H3K9 acetylation levels, suggesting that histone H3K9 acetylation could regulate the expression of the porcine FSHR gene.
248 F(2) animals from a Duroc and Meishan cross were genotyped for three FSHR SNPs at positions 74, 532 and 1166, and these were correlated with the phenotypes of litter size and corpus luteum number
findings suggest the FSH receptor may be involved in the early follicle formation in pigs, which begins during prenatal life.
FSHR is expressed in the hamster ovary starting from the fetal life to account for FSH (show BRD2 ELISA Kits)-induced primordial follicle formation and cyclic AMP (show TMPRSS5 ELISA Kits) production.
The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants.
follicle stimulating hormone receptor
, follicle-stimulating hormone receptor
, gonadotropic hormone I
, follicle-stimulating hormone receptor-like
, FSH receptor
, follitropin receptor